Could a muscle relaxant lift depression? new trial underway

NCT ID NCT07621237

Recruiting now Symptom relief Sponsor: Tonix Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 2 trial tests whether TNX-102 SL, a tablet taken under the tongue at bedtime, can improve depression symptoms in adults with moderate to severe major depressive disorder. About 360 participants will receive either the drug or a placebo nightly for 6 weeks. Researchers will measure changes in depression scores and monitor safety.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: TNX-102 SL (cyclobenzaprine) taken as a tablet under the tongue at bedtime
What this could lead to: If it works, this could offer a new nightly treatment option for people with major depression, potentially easing symptoms with a different approach than standard antidepressants.
What could go wrong: This is an early Phase 2 trial, so results may not confirm effectiveness. The drug is a muscle relaxant repurposed for depression, and it may cause side effects like drowsiness or dizziness. Success is not guaranteed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION MAJOR DEPRESSIVE DISORDER (MDD) MAJOR DEPRESSIVE EPISODE (MDE)

Contacts and locations

Locations

Activmed Practices & Research, Llc - Methuen
NOT_YET_RECRUITING

Methuen, Massachusetts, 01844, United States
Artemis Institute For Clinical Research - San Diego
NOT_YET_RECRUITING

San Diego, California, 92123, United States
Austin Clinical Trial Partners
NOT_YET_RECRUITING

Austin, Texas, 78737, United States
Boeson Research Pvu
NOT_YET_RECRUITING

Provo, Utah, 84604, United States
Central Miami Medical Institute Llc.
NOT_YET_RECRUITING

Miami, Florida, 33125, United States
Chicago Research Center
NOT_YET_RECRUITING

Chicago, Illinois, 60634, United States
Clinical Neuroscience Solutions Inc. - Jacksonville
NOT_YET_RECRUITING

Jacksonville, Florida, 32256, United States
Clinical Neuroscience Solutions Inc. - Memphis
NOT_YET_RECRUITING

Mephis, Tennessee, 38119, United States
Clinical Neuroscience Solutions Inc. - Orlando
RECRUITING

Orlando, Florida, 32801, United States
Coastal Carolina Research Center
NOT_YET_RECRUITING

North Charleston, South Carolina, 29405, United States
Delricht Research - New Orleans
RECRUITING

New Orleans, Louisiana, 70115, United States
Delricht Research - Plano
NOT_YET_RECRUITING

Plano, Texas, 75024, United States
Delricht Research - Rockville
NOT_YET_RECRUITING

Rockville, Maryland, 20852, United States
Evergreen Clinical Trials
NOT_YET_RECRUITING

Norcross, Georgia, 30092, United States
IMA Clinical Research- Phoenix
NOT_YET_RECRUITING

Phoenix, Arizona, 85012, United States
Ima Clinical Research - Nyc Midtown
NOT_YET_RECRUITING

New York, New York, 10036, United States
Inland Psychiatric Medical Group, Inc. - Chino
NOT_YET_RECRUITING

Chino, California, 91710, United States
K2 Medical Research - Maitland
NOT_YET_RECRUITING

Maitland, Florida, 32751, United States
K2 Medical Research - Tampa
NOT_YET_RECRUITING

Tampa, Florida, 33634, United States
Medical Research Group of Central Florida
NOT_YET_RECRUITING

Orange City, Florida, 32763, United States
Nrc Research Institute
NOT_YET_RECRUITING

Orange, California, 92868, United States
Redbird Research
NOT_YET_RECRUITING

Las Vegas, Nevada, 89119, United States
Revival Research Institute, Llc - McKinney, Tx
NOT_YET_RECRUITING

McKinney, Texas, 75071, United States
Sunwise Clinical Research, Llc
NOT_YET_RECRUITING

Walnut Creek, California, 94596, United States
Synergy Research - San Diego
NOT_YET_RECRUITING

Lemon Grove, California, 91945, United States

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