Brain implant trial targets severe depression

NCT ID NCT06423430

Recruiting now Disease control Sponsor: Abbott Medical Devices Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 30, 2026 · Updated 3 times

Summary

This study tests whether deep brain stimulation (DBS) can help people with severe depression that hasn't improved with multiple treatments. Researchers will implant a device that sends electrical pulses to a specific brain area. The trial includes 100 adults and compares active stimulation to a sham (inactive) device to see if it safely reduces depression symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: deep brain stimulation (DBS) device
What this could lead to: If it works, this could offer a new option for people with severe depression that hasn't responded to other treatments.
What could go wrong: This is an early-stage trial with only 100 participants, so results may not apply to everyone. Brain surgery carries risks like infection or bleeding, and the device may not work for all.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depressive Disorder, Treatment-Resistant major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TREATMENT RESISTANT DEPRESSION

Contacts and locations

Locations

Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States
CHI St. Luke's Health Baylor College of Medicine Med. Ctr
RECRUITING

Houston, Texas, 77030, United States
Emory University Hospital
RECRUITING

Atlanta, Georgia, 30322, United States
Indiana University
RECRUITING

Indianapolis, Indiana, 46202, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States
Mount Sinai Hospital
RECRUITING

New York, New York, 10019, United States
Pennsylvania Hospital
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Robert Wood Johnson University Hospital
RECRUITING

New Brunswick, New Jersey, 08901, United States
Rush University Medical Center
RECRUITING

Chicago, Illinois, 60612, United States
The Cleveland Clinic Foundation
RECRUITING

Cleveland, Ohio, 44195, United States
The Methodist Hospital
RECRUITING

Houston, Texas, 77030, United States
The Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States
UCLA Department of Psychiatry
RECRUITING

Los Angeles, California, 90095, United States
USC University Hospital
RECRUITING

Los Angeles, California, 90033, United States
USF Health
RECRUITING

Tampa, Florida, 33613, United States
University of Alabama at Birmingham - Dept. of Psychiatry
RECRUITING

Birmingham, Alabama, 35294, United States
University of California at Davis
RECRUITING

Sacramento, California, 95817, United States
University of Minnesota Medical Center Fairview
RECRUITING

Minneapolis, Minnesota, 55455, United States
University of Texas Southwestern Medical Center at Dallas
RECRUITING

Dallas, Texas, 75390, United States
University of Utah Hospital
RECRUITING

Salt Lake City, Utah, 84132, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

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