Brain zaps for depression: scientists hunt for clues in electrical signals

NCT ID NCT05773755

Recruiting now Disease control Sponsor: Helen Mayberg, MD Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests deep brain stimulation (DBS) in 20 people with severe depression that hasn't improved with other treatments. The device delivers electrical pulses to a brain region called the subcallosal cingulate, which may reset mood circuits. Researchers will record brain signals to find markers that predict who responds best, aiming to personalize future therapy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Deep brain stimulation (DBS) device
What this could lead to: If successful, this could help doctors better adjust DBS settings for each patient, improving depression treatment outcomes.
What could go wrong: This is a small, early-stage study with only 20 participants, and it is not designed to prove the treatment works. Risks include surgery complications and unknown long-term effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depressive Disorder, Treatment-Resistant major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER TREATMENT RESISTANT DEPRESSION

Contacts and locations

Locations

Icahn School of Medicine at Mount Sinai, Mount Sinai West
RECRUITING

New York, New York, 10019, United States

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