Magic mushroom chemical under the microscope: can brain scans reveal how it fights depression?

This study uses brain imaging (PET scans) to explore how psilocybin, the active ingredient in magic mushrooms, affects brain connections in adults with treatment-resistant depression. Twelve participants will receive psilocybin, with or without risperidone, to see if changes in synaptic density relate to antidepressant effects. The goal is to understand the brain mechanisms behind psilocybin's potential benefits, not to test it as a treatment.