Mood disorder

This study tests whether brain imaging and clinical data can help select the best treatment for people with depression that hasn't improved with standard therapies. Participants receive either repetitive transcranial magnetic stimulation (rTMS) or ketamine, and researchers check …

This study compares two approved antipsychotic drugs, risperidone and cariprazine, in 50 adults with bipolar 1 disorder experiencing acute mania. Participants take one of the drugs for 6 weeks, and doctors measure how well symptoms improve using a standard mania rating scale. The…

This study tests whether adding a drug called NRX-101 (a mix of D-cycloserine and lurasidone) to transcranial magnetic stimulation (TMS) helps people with treatment-resistant depression more than TMS alone. About 400 adults who have not had TMS before will receive either the drug…

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

This study tests whether adding mental health screening and family planning counseling to routine baby check-ups helps new mothers. About 920 migrant, refugee, and underserved women in Jordan will take part. They will be screened for postpartum depression, receive support or refe…

This phase 2 trial compares the drug quetiapine with interpersonal and social rhythm therapy (IPSRT) in 216 people with bipolar II disorder who have disrupted daily rhythms. Participants will be randomly assigned to one of the two treatments for 12 weeks. Researchers will measure…

This study tests whether a nasal spray containing esketamine and dexmedetomidine, given twice after childbirth, can lower the chance of postpartum depression in women who already had mild depressive symptoms during pregnancy. Esketamine is a fast-acting antidepressant, and dexmed…

This study compares dapagliflozin and metformin for managing weight gain caused by antipsychotic medications. About 110 adults aged 16 and older will take one of the drugs plus lifestyle advice for 26 weeks. The goal is to see which drug works better and is safer for weight contr…

This study tests a program that combines group counseling, financial literacy training, and savings accounts to help Ugandan teens with HIV manage depression and stick to their medication. About 588 adolescents aged 15-19 will take part. The goal is to see if this approach can re…

This study tests whether doulas can successfully deliver an 8-week program called YouMatter to new or expecting mothers at risk for postpartum depression. The program combines mental health support, parenting tips, and self-care. Forty mothers with mild depression symptoms will p…

This study tests whether carefully reducing antipsychotic medication in stable schizophrenia patients can improve their daily functioning compared to staying on the same dose. Researchers will group 288 adults aged 18–60 by their specific psychosis type and randomly assign them t…

This study tests a short case management program for people who have been involuntarily admitted to a psychiatric hospital. The program, designed with input from people who have experienced coercion, provides up to five sessions with a nurse or social worker starting during the h…

This early study tests a new device called the Motif XCS System for people with severe depression that hasn't improved with multiple medications. The device is implanted in the skull and stimulates a key brain area without piercing the brain's protective covering. The main goal i…

This study tests if special reflective roof coatings can lower indoor temperatures and improve health in Fiji. About 800 households will receive either a cool roof or usual care. Researchers will measure heart rate, blood sugar, depression, and other heat-related symptoms to see …

This study tests whether a personalized program of exercise, diet, sleep support, social activities, and a weight-loss drug (semaglutide) can improve mental functioning in 140 adults with depression, bipolar disorder, or schizophrenia. Participants are randomly assigned to the pe…

This study tests whether tracking smartphone activity and offering extra support from peer specialists can help veterans with serious mental illness avoid emergency room visits and hospital stays. About 400 veterans who are at high risk will take part. The goal is to catch early …

This study is for adults aged 40 and older who have two or more chronic conditions like high blood pressure, diabetes, or depression. Researchers are testing a program that includes a digital decision-support system for doctors, telemedicine for specialist advice, and a mobile ap…

This study will test whether having a pharmacist review a patient's genetic test results can improve treatment for major depression. 220 adults in Pennsylvania who are starting or changing antidepressant medication will be randomly assigned to either receive this specialized medi…

This study looks at whether a program called EMPOWER, led by trained peer supporters, can help homeless veterans with substance use or mental health issues stay engaged in care and avoid repeated hospital stays or emergency visits. About 278 veterans in permanent supportive housi…

This study will test whether applying a special heat-reflecting coating to roofs can improve the health and well-being of 800 households in Colima, Mexico. The coating is designed to keep homes cooler indoors, which may help lower heart rate, improve blood sugar control, reduce d…

This study looks at whether an online education and support program can help people with schizophrenia or bipolar disorder stick to their medication plans. Researchers will compare digital questionnaires with pharmacy records to measure adherence. About 1,640 adults in Spain will…

This study looks at whether extra education from a pharmacist can help people aged 18-60 who are starting a new antipsychotic medication for conditions like schizophrenia or bipolar disorder. The goal is to see if this support reduces weight gain and other metabolic side effects.…

This study tests a new group program called PEDAL for people with bipolar disorder. It combines standard group education with digital tools like an app-based mood diary and online resources to help manage rapid mood swings. The trial will involve 120 participants across five site…

This small pilot study will test whether adding ketamine to cognitive behavioral therapy (CBT) is safe and feasible for people with both alcohol use disorder and major depression. Twenty participants will receive three ketamine injections over six weeks along with CBT sessions. T…

This study tests a new, intensive form of brain stimulation for elderly people (65 and older) who have depression that hasn't improved with medication and also have memory or thinking problems. The treatment uses magnetic pulses targeted to a specific brain area, guided by brain …

This pilot study tests whether a non-invasive brain stimulation technique called tACS can help teens (ages 12-18) with major depression when added to their usual medication. Thirty participants will receive either real or sham stimulation daily for several weeks. The goal is to s…

This study tests a comprehensive management service package for older adults (65+) who have two or more chronic conditions like high blood pressure, diabetes, or arthritis. The package includes digital tools, personalized lifestyle advice, and long-term support. Researchers will …

This study will test if a smartphone app that analyzes speech can accurately screen for depression and anxiety in university students. Researchers will enroll 80 students aged 16 to 25 and compare the app's results with standard questionnaires. The goal is to see if voice pattern…

This observational study will enroll 440 Danish-speaking adults over 50 to see if an artificial intelligence model can detect dementia and mild cognitive impairment from speech recordings. Participants will complete standard cognitive tests and describe a picture while being reco…

This study explores whether routine blood vessel tests can help identify depression in people with chronic atrophic gastritis, a stomach condition. Many patients with this disease have undiagnosed depression due to stigma. Researchers will use ultrasound and other vascular measur…

This study will check if an artificial intelligence (AI) system can diagnose depression as accurately as a psychiatrist. About 100 adults with depression will take part. Their AI-based diagnosis will be compared to the diagnosis made by a mental health specialist.

This study will test whether measuring a specific abnormal protein (alpha-synuclein) in spinal fluid can reliably distinguish dementia with Lewy bodies (DLB) from Alzheimer's disease. Researchers will collect samples and perform cognitive tests on 286 older adults with suspected …

This pilot study will test a 10-session virtual group program called Parents and Babies, designed to prevent postpartum depression in LGBTQ+ parents. The program teaches coping skills based on cognitive-behavioral therapy. Researchers will enroll 16 LGBTQ+ individuals who are pre…

This study tests a new digital program called Together in Parenting (TIP) designed to prevent postpartum depression in new fathers. About 90 English-speaking fathers-to-be or new fathers will use podcasts and handouts. The goal is to see if the program is easy to use and helpful,…

This study tests a digital program called 'What Were We Thinking' (WWWT) to prevent postpartum depression and anxiety in first-time mothers in Chile. The program includes short videos, text message prompts, and a virtual group session. Researchers will compare mothers who receive…

This study tests whether trained youth mentors can deliver a brief therapy to reduce suicide risk in Hispanic adolescents aged 12-17. Participants will either receive 6 therapy sessions with a mentor or usual care. The goal is to see if this approach is feasible and helps reduce …

This study tests a community-based program to help Black and Hispanic teens aged 15-20 cope with chronic stress and prevent depression. Participants will join peer groups to learn skills and will be tracked for 2 years. The goal is to reduce depressive symptoms and improve physic…

This study tests whether a 4-hour resilience workshop can prevent PTSD and depression in 800 first responders in New York and Texas. Participants will be randomly assigned to the workshop or a control group and followed for one year. The goal is to see if the training helps them …

This study tests whether an AI-informed peer-mentoring program can help healthy teens and young adults (ages 12-25) manage stress and build social skills, lowering their risk of developing anxiety or depression. Researchers will compare this program to standard mentoring and heal…

This study tests whether a single dose of intranasal dexmedetomidine, given just before labor pain relief, can lower the chance of postpartum depression (PPD). Researchers will enroll 270 women having vaginal deliveries and randomly give them either the drug or a placebo. The mai…

This study tests whether digital exercises on a smartphone can help teens aged 16-19 avoid relapse of depression or anxiety. Participants who have recovered from a past episode will use a research app to work through thoughts and feelings while they feel well. Some will join onli…

This study tests whether mindfulness-based cognitive therapy (MBCT) delivered through video calls can prevent depression from coming back. 315 adults with recurrent depression in partial remission will be randomly assigned to group MBCT, a self-help manual with minimal video supp…

This study in Zimbabwe will screen women of childbearing age and high school students for HPV and Hepatitis B, then offer vaccines to those who are eligible. It also includes cognitive behavioral therapy for mental health issues. The goal is to see if this combined approach can p…

This study will test whether a personalized smartphone app can help prevent anxiety and depression in adults who do not currently have these conditions. About 2,595 people in Spain and Chile will use either a highly interactive app (Pandora-1), a simpler educational app (Pandora-…

This study tests whether a personalized smartphone app can prevent depression and anxiety in adults who do not currently have these conditions. Over 9,000 participants in Spain will use the app, which creates a custom plan with activities like exercise, sleep improvement, and pro…

This pilot study tests whether a faster schedule of non-invasive magnetic brain stimulation, called accelerated intermittent theta burst stimulation (iTBS), is practical and safe for adults with both PTSD and major depression. Participants receive six short sessions per day for f…

This pilot study will test whether a high-fat, low-carbohydrate ketogenic diet can reduce symptoms of bipolar disorder when added to standard treatments. The study will enroll 100 adults in rural Alabama and measure changes in mania severity. The goal is to see if a dietary appro…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve depression in people with bipolar disorder. Researchers use brain scans to create a personalized map for each participant, targeting the exact brain circuits involved in mood shifts. Parti…

This Phase 3 trial tests whether pramipexole, a dopamine-boosting drug, can ease anhedonia (loss of pleasure) in people with bipolar depression. 126 participants will receive either pramipexole or a placebo alongside their usual mood stabilizer for 6 weeks. The study aims to impr…

This trial investigates whether the Healthy Minds Program, a mobile meditation training app, can reduce symptoms of depression in adults. About 1,500 participants with elevated depressive symptoms will complete a 4-week well-being program using the app. Researchers will measure c…

This study tests whether a small device that gently stimulates a nerve in the ear can help reduce depression in people with Parkinson's disease. Participants use the device at home twice a day for 14 days. The trial measures changes in mood and brain activity to see if this simpl…

This pilot study will test whether a mobile phone app can help reduce depression symptoms in African American adults. Eight participants will attend six weekly 90-minute classes through the app and complete surveys over four months. The goal is to see if this approach is effectiv…

This study tests whether a structured, midwife-led review of the childbirth experience can improve mental health in new mothers and fathers. The intervention involves a 45-60 minute session where parents discuss their birth story, receive emotional support, and get clarifications…

This study tests a mobile app called Maya that teaches cognitive behavioral therapy skills to adults who recently had a stroke and feel depressed or anxious. Ten participants will use the app for a few weeks to see if it is easy to use and helps improve their mood. The goal is to…

This study tests whether brief, 1-2 minute videos featuring personal stories from other parents can reduce stigma and improve help-seeking among parents of children aged 6-18 with depression, ADHD, or substance use problems. Researchers will recruit 1,600 parents online and rando…

This study compares two drugs, lumateperone and cariprazine, when added to a mood stabilizer for people with bipolar I depression. Researchers will track changes in depression symptoms over 8 weeks using standard rating scales. The goal is to see which drug works better and has f…

This phase 2 trial tests whether a single dose of psilocybin, the active ingredient in magic mushrooms, can improve depression in people with Parkinson's disease. Forty participants will receive a low to high dose with psychological support. The study measures changes in depressi…

This pilot study tests whether a headband that delivers timed sound pulses (pink noise) can improve sleep in 25 people with both depression and insomnia. Participants wear the device nightly for four weeks, alternating between active stimulation and sham (placebo) sound. The goal…

This study tests whether an 8-week program of yoga and meditation delivered through a mobile app can reduce anxiety in adults with stable rheumatoid arthritis. About 100 participants will either use the app daily or continue with standard care. Researchers will measure changes in…

This study investigates whether a single session of whole-body hyperthermia (using an infrared sauna) can quickly improve symptoms of depression and anxiety. Researchers will measure brain activity, inflammation, and mood changes in four groups: healthy postpartum women, postpart…

This study will test whether smartphone sensors can detect when someone with early psychosis is feeling anxious or depressed and then offer a short mindfulness or psychoeducation exercise. Ten adults aged 18–50 with early psychosis and mild mood symptoms will use the app for 10 w…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve cognitive flexibility—the ability to adapt thinking—in people with major depression. 105 participants will receive either active stimulation to two brain areas, active stimulation to one a…

This study tests an 8-week group program that combines mindfulness, gentle movement, breathing exercises, healthy eating tips, and art activities for adults aged 55 and older with mild-to-moderate depression or loneliness. The goal is to see if the program improves mood, reduces …

This study tests a new non-invasive brain stimulation tool called kTMP to treat anhedonia, the loss of interest or pleasure, in people with major depressive disorder. 104 participants will receive either active or sham stimulation. The main goal is to see if kTMP changes brain ac…

This study tests whether taking a probiotic supplement called Ecologic® Barrier for 16 weeks can reduce depressive symptoms and change brain activity in adults aged 25-40 with mild-to-moderate depression. Participants will be randomly assigned to receive the probiotic or a placeb…

Many Asian Americans with depression also suffer from physical symptoms like pain or fatigue, but no proven treatment addresses both together. This study will test whether combining a stress management program with Qigong/Tai Chi movements is practical and acceptable for 70 adult…

This study tests whether a digital mental health platform called NAVO:J can help teens feel better. About 250 students will use the app in weekly group sessions at school for 17 weeks. Researchers will measure changes in depression, anxiety, stress, and resilience to see if the p…

This study tests a two-session Zoom-based therapy designed to change beliefs about mental health treatment in Deaf adults who are not currently in care. Researchers will compare those who receive the therapy to a waitlist group to see if it increases treatment-seeking and reduces…

This study tests whether adding nitrous oxide (EMONO) to standard antidepressants can reduce depressive symptoms in nursing home residents aged 60 and older who have moderate to severe dementia. Participants receive either EMONO or medical air (placebo) via a face mask over sever…

This study will test whether Reiki therapy, a gentle hands-on energy technique, can improve recovery, comfort, and mood in women who have had a cesarean section. Eighty new mothers will receive three Reiki sessions on days 1, 2, and 7 after birth, in addition to standard care. Re…

This study tests a 12-week telehealth program called PARTNER-MH, where trained peer specialists help minoritized veterans navigate mental health care, address social needs, and improve communication with clinicians. The trial will enroll 268 veterans with depression, anxiety, or …

This study tests whether combining the medication duloxetine with a structured walking program can improve physical function, reduce pain, and ease depressive symptoms in veterans with knee osteoarthritis. Participants will be assigned to either the drug-plus-exercise group or a …

This study tests whether 5 days of accelerated transcranial magnetic stimulation (TMS) can quickly reduce depression symptoms. 264 adults with major depressive disorder will receive either real or sham stimulation, along with brain scans and mood tracking. The goal is to see if t…

This study tests whether adding a special fish oil supplement (CreNeuroS) to the antidepressant escitalopram helps reduce depression symptoms more than escitalopram alone. Eighty adults with moderate to severe major depressive disorder will take either the fish oil or a placebo f…

This pilot study will test whether a 6-week app-based mental fitness program can improve wellbeing and self-compassion in anesthesiology residents. Sixty residents will be randomly assigned to either the mental fitness app or a control program. The main goal is to see if such a p…

This study tests whether virtual reality (VR) can help improve thinking and daily functioning in people aged 70 and older who have depression. Participants will do 12 VR sessions over 6 weeks, doing tasks like sorting groceries or following recipes. The main goal is to see if sen…

This study tests an oral ketamine capsule (KET-AD) designed to be abuse-deterrent in adults with treatment-resistant bipolar depression. About 160 participants will receive either KET-AD or a placebo, taken three times a week for up to 7 weeks, alongside their usual treatment. Th…

This study tests three types of support—individual counseling, group stress and budget workshops, or a mix—for health students aged 18-30 who face financial hardship. About 110 students from the University of Rouen will try these programs, and researchers will track changes in an…

This study tests a program called Natural Psychotherapy to see if it can reduce anxiety and depression symptoms in 3,000 Chinese students aged 7 to 18. Participants will be randomly assigned to the program or a control group, and their progress will be tracked for 6 months. The g…

This study tests a digital cognitive behavioral therapy (CBT) program with weekly phone coaching for pregnant women with depression. Researchers will enroll 1,000 women between 12 and 22 weeks pregnant who have depressive symptoms. The goal is to see if the program is easy to use…

This pilot study will test a stepped-care approach for depression in 40 adults from primary care clinics. Participants will either use a mood-tracking app (Moodivate) alone, receive telehealth therapy, or start with the app and step up to therapy if needed. The main goal is to se…

This study tests whether a tailored online support group (VOCALE LBD) can reduce depression in family caregivers of people with Lewy body dementia (LBD). LBD caregivers often face high stress and depression rates. The 8-week program brings small groups together online to discuss …

This study tests whether Functional Electrical Stimulation (FES) of facial muscles is a safe and effective way to reduce depression symptoms in people with major depressive disorder (MDD). About 60 adults with MDD who have not responded to up to two treatments will receive FES or…

This study tests whether a high-dose version of a gentle brain-stimulation device (tDCS) used at home works better than the standard dose for easing major depression. About 270 adults with depression will use the device daily and be monitored for changes in mood and thinking. The…

This study tests whether reading specific self-help books can lower anxiety, depression, and rumination in university students aged 18-25. 110 students from health science programs will be randomly assigned to read one of two books or join a waiting list. Over 8 weeks, they will …

This study will test two smartphone apps, Tankevirus and Grubl, designed to help people with mild to moderate anxiety and depression. About 1000 Norwegian adults will use one of the apps or a placebo app for two weeks. Researchers will measure changes in symptoms and quality of l…

This study compares an AI-delivered digital therapy called Nook to standard cognitive behavioural therapy (CBT) for people with moderate depression and/or anxiety. 400 participants aged 16-64 in the UK will be randomly assigned to either the AI program or human-led therapy. The g…

This study tests whether psilocybin, the active ingredient in magic mushrooms, can help veterans with depression that hasn't improved with at least two other treatments. 240 veterans will receive either psilocybin or a placebo in a controlled setting. The goal is to see if it red…

This study tests a group-based program called the Thinking Healthy Extended Program (THEP) for new mothers with mild to moderate depression. The program is delivered at community health centers in China and aims to improve maternal mental health and child development. Researchers…

This pilot study will test whether adding a digital app to group cognitive-behavioral therapy (CBT) helps teens aged 12-17 who have both depression and overweight. Sixty participants will be randomly assigned to either CBT plus the app or CBT alone. The main goal is to see if the…

This trial compares two short, one-session therapies for teens aged 12-17 hospitalized for suicidal thoughts or attempts. One therapy (CAMS-BI) focuses on understanding and addressing the personal reasons behind suicidal feelings, while the other (Stanley-Brown Safety Planning) b…

This study looks at whether aerobic exercise (like brisk walking) and mindful breathing can help adults with major depressive disorder feel better and improve their quality of life. Participants are split into three groups: one does 45 minutes of moderate exercise three times a w…

This study tests whether a drug called allopregnanolone can reduce depression and pain in veterans who have had a mild traumatic brain injury (TBI). About 132 participants will receive either the drug or a placebo through an IV. Researchers will check symptoms during the infusion…

This study will test a behavioral activation therapy program delivered via telehealth for Spanish-speaking adults with depression living in rural areas of Montana and New Mexico. The goal is to see if the program improves depressive symptoms and keeps people engaged in mental hea…

This study tests whether lumateperone (Caplyta) can help older adults (60+) whose depression hasn't improved with other treatments. One hundred participants will take either the drug or a placebo alongside their current antidepressant for 10 weeks. Researchers will measure change…

This study tests a non-invasive brain stimulation technique called tTIS for adults with major depressive disorder. Sixty participants will receive either active stimulation targeting specific brain areas or a sham (fake) treatment over 5 days. Researchers will measure changes in …

This early-stage study tests whether a single 25 mg dose of psilocybin can help people who still feel emotionally flat or uninterested in things despite taking antidepressants. About 90 adults aged 18-65 will receive either psilocybin or a placebo, and researchers will use brain …

This study tests whether baricitinib, an anti-inflammatory drug, can improve depression and cognitive symptoms in 30 male former football players aged 40-55 with at least 10 years of play. Participants take the drug every other week for 6 weeks, and researchers use brain scans an…

This study tests whether using a personalized medicine clinic to tailor antidepressant doses can improve depressive symptoms. Researchers will enroll 200 adults with depression and track changes using a standard depression survey. The goal is to see if customizing medication base…

This study will test an internet-based therapy program for 366 adults with anxiety or depression. The program starts with self-guided modules, and based on early progress, some participants will also get live sessions with a therapist. The goal is to see if personalizing the trea…

This study tests whether Xiaochaihu Granules, a traditional Chinese herbal medicine, can help with depression in people who have had a stem cell transplant. About 46 patients will receive either a low or high dose of the granules for 100 days, alongside standard care. Researchers…

This study tests a non-invasive brain stimulation method called temporal interference stimulation (TI) to see if it can improve mood in people with depression. Forty-three adults with moderate to severe depression will receive 10 sessions of TI over two weeks. Researchers will us…

This study will test whether psilocybin, the active ingredient in magic mushrooms, can help treat depression. Fifty adults with depression will receive a 25 mg capsule of synthetic psilocybin along with therapy. Researchers will use MRI brain scans and other tests to see how psil…

This study tests whether combining whole-body hyperthermia (a controlled rise in body temperature) with cognitive behavioral therapy (CBT) can help adults with major depressive disorder. Sixty participants will receive either CBT, heat sessions, both, or neither, to see if the co…

This study tests whether a mobile app called SocialRx, which recommends personalized arts and cultural activities, can improve depression, anxiety, and loneliness in teens aged 15-18. About 230 teens with depression or anxiety will either use the app for a year or continue their …

This study tests if combining a gentle electrical brain stimulation (tDCS) with computer-based memory games can improve thinking and memory in adults over 60 with recurrent depression. Participants will be assigned to one of three groups to compare different combinations of activ…

This phase 2 trial tests whether a single infusion of tocilizumab, a drug that blocks the inflammatory molecule IL-6, can reduce depressive symptoms in 32 adults with treatment-resistant major depression. Participants must have high inflammation levels (CRP ≥3 mg/L) and will rece…

This study tests whether a self-paced online program called WeACT can help family caregivers of people with dementia feel better mentally and emotionally. About 40 adult caregivers with mild to moderate depression will use the program for six weeks. Researchers will check if care…

This study tests whether an AI-assisted writing program can help Chinese teenagers (ages 10-19) who are struggling with prolonged grief after losing a loved one. Participants will complete three guided writing sessions over six days, with some receiving personalized AI feedback. …

This study looks at whether a 6-week program that combines problem-solving therapy with small rewards can help new mothers feel less depressed and drink less alcohol. About 30 mothers who gave birth in the last year will take part. Half will get the program, and the other half wi…

This study will enroll 250 pregnant or postpartum women with moderate-to-severe depression to see if adding digital data from smartphones and smartwatches can better predict how well they respond to treatment. Participants will receive a 12-week program that includes online cogni…

This study tests whether adding allopurinol, a drug usually used for gout, to the antidepressant sertraline can better relieve symptoms of major depressive disorder. Researchers will enroll 70 adults with moderate to severe depression and measure changes in their depression score…

This study tests whether a probiotic called Bifidobacterium PB-18 can improve symptoms of mild to moderate depression in adults aged 18 to 65 who are not taking antidepressants. Participants will take either the probiotic or a placebo daily for 8 weeks. Researchers will measure d…

This study tests an online platform called PURSUIT that teaches coping skills to Michigan youth aged 8-18 and their caregivers. The program provides cognitive-behavioral techniques for managing pain, stress, and mood, with extra substance use prevention content for teens 12 and o…

This study tests whether a group retreat using psilocybin (the active ingredient in magic mushrooms) can safely help healthcare clinicians who feel depressed and have lost meaning in their work. Seventy-two doctors, nurses, and physician assistants will take part in small groups,…

This study tests whether combining ketamine infusions with dialectical behavioural therapy (DBT) can reduce suicidal thoughts more effectively than a placebo plus DBT. About 120 adults with borderline personality disorder and treatment-resistant depression or bipolar disorder wil…

This phase 2 trial will test whether giving psilocybin (the active ingredient in magic mushrooms) along with group cognitive behavioral therapy is acceptable and feasible for people with major depression. Thirty adults with current depressive symptoms will receive two doses of ps…

This study tests whether giving psilocybin—a psychedelic drug being studied for depression—under general anesthesia can hide its mind-altering effects. That would allow researchers to run a truly blinded trial where neither patients nor doctors know who got the real drug. Ten adu…

This pilot study tests whether repetitive transcranial magnetic stimulation (rTMS) is safe and helpful for depression and fatigue in adults with multiple sclerosis (MS). About 20 participants will receive daily rTMS sessions for 5 days, with assessments before, after, and at a 4-…

This study tests whether a single 25 mg dose of psilocybin, given with therapy, can ease depression in people with bipolar II disorder who haven't improved with standard treatments. About 90 adults aged 19-65 will receive either the full dose or a very low placebo dose, and their…

This study compares doing brain stimulation (tDCS) at home versus in the hospital for people with moderate to severe depression. The goal is to see if home treatment works just as well, making care more accessible. Sixty-six adults will receive 20 sessions over two weeks, with nu…

This study tests whether daridorexant, a sleep medication, can help people who have both major depression and insomnia. Researchers want to see if it improves sleep quality and also eases depressive symptoms. About 134 adults will take either daridorexant or a placebo for three m…

This study tests a smartphone app called Senyo Health for people with bipolar disorder who also struggle with alcohol or drug use. The app offers therapy, rewards for healthy behaviors, and weekly check-ins with a care manager. The goal is to see if the app is easy to use and hel…

This study compares acupuncture with standard medication to see which is more effective and affordable for reducing anxiety and mild to moderate depression in adults in China. About 120 people who haven't had mental health treatment in the past 6 months will choose their preferre…

This study looks at whether the type of education patients receive about a single propofol sedation session can change how well it works for depression. Twenty adults with moderate to severe major depressive disorder will get one propofol infusion and be randomly assigned to eith…

This study tests a 6-week program for adults 55 and older that combines group book discussions with simple mouth exercises. The goal is to see if it can reduce depression, improve physical and oral health, and boost mental toughness. Half of the 60 participants will do the progra…

This study looks at whether combining group cardiovascular exercise with group therapy can help reduce symptoms of anxiety and depression in adults living in rural areas. Twenty participants with generalized anxiety or depressive disorders will take part in a structured program. …

This study tests an 8-week mindfulness program designed to help nursing students reduce stress, anxiety, and depression while improving their emotional control. About 93 students will learn meditation, breathing exercises, and mindful movement. The goal is to see if these techniq…

This study tests an 8-week digital program that helps migrants in Sweden improve their mental health through better sleep, diet, physical activity, and social connections. 240 adults with moderate stress, anxiety, or depression will either get the program or a general wellness mo…

This study tests a program that offers mental health screening, therapy, and follow-up to pregnant women who are in the hospital for medical complications. About 50 participants will receive brief counseling and symptom tracking during their stay and for three months after. The g…

This pilot study tests whether tailoring psilocybin-assisted therapy to a person's preferences (music or mindfulness) is practical and helpful for treatment-resistant depression. Sixteen adults will receive two doses of psilocybin, each paired with a different therapy style, to s…

This study tests whether an interactive virtual reality (VR) program can help reduce pain, anxiety, and fatigue in 20 hospitalized palliative care patients. Participants use a VR headset with sensors to interact with a calming natural environment for 10 minutes daily over 14 days…

This study tests a computerized cognitive behavioral therapy (cCBT) program designed to help caregivers of veterans who have mild to moderate depression. Twenty caregivers will use the online course over several weeks. Researchers will measure how satisfied participants are and w…

This study tests a guided self-help program for veterans with moderate depression. Participants follow a workbook and get coaching sessions from their VA primary care team. The goal is to see if this approach is practical and helps reduce depression symptoms, potentially making m…

This study tests whether two anti-inflammatory medications, celecoxib or minocycline, can reduce depression symptoms in adults with major depressive disorder or bipolar depression. About 42 participants will take one of the drugs for 8 weeks and have their depression levels measu…

This study will develop and test a digital mental health program called 'VIBE in the Parks' for teens aged 13-24 who use Chicago Park District programs. About 268 participants will either get access to this program or a digital CBT workbook. The goal is to see if the program help…

This study tests a new drug called PDC-1421 to see if it is safe and helps with depression in people who have cancer. About 12 adults with mild to severe depression and stage I-III cancer will take the drug for up to 5 weeks. Doctors will check mood changes using a standard depre…

This study tests whether a type of cognitive training called Action-Based Cognitive Remediation (ABCR) can improve thinking skills in people with various psychiatric conditions like depression, schizophrenia, anxiety, PTSD, and autism. Participants will complete computer exercise…

This study tests a type of brain stimulation called theta burst stimulation (TBS) for people with depression that hasn't improved with medication. About 120 adults and teens will either get real TBS or a fake version first, then real TBS later. Researchers will measure changes in…

This study looks at whether adding sleep-focused treatments to standard psychiatric care can reduce suicide risk in young adults. About 90 college students with suicidal thoughts and sleep problems will be randomly assigned to one of three sleep interventions. Researchers will tr…

This study will test if an internet-based cognitive behavioral therapy (iCBT) program can help reduce symptoms of mild-to-moderate anxiety and depression in adults in Singapore. About 390 participants will either receive the 8-week online program with counselor check-ins or conti…

This study tests a program designed to help low-wage hospital workers manage depression and become more active. The program includes counseling, work coaching, and text message support. About 60 workers will take part to see if the program is practical and improves mood, stress, …

This study tests whether a midwife-led digital follow-up program can reduce postpartum depression and improve breastfeeding success in women who had a C-section. About 104 women will either get the digital program or standard care. The goal is to see if extra support through phon…

This study tests a web-based program designed to help advanced cancer patients manage symptoms like depression, pain, fatigue, and sleep problems, while also supporting their caregivers. The program combines online tools with guidance from healthcare professionals. Researchers wi…

This study tests an experimental tablet called JS1-1-01 in 180 adults with moderate to severe depression. Participants will take either a low dose, high dose, or placebo for 8 weeks. The goal is to see if the drug safely reduces depression symptoms better than a placebo.

This study tests whether a 3-week bedside yoga program, added to standard depression treatment, can improve mother-infant bonding and reduce depression in new mothers. Fifty-two mothers with perinatal depression will be randomly assigned to yoga plus usual care or usual care alon…

This study tests whether a smartphone app called SOLOMIYA is helpful and easy to use for people living under the stress of war in Ukraine. About 80 adults with mild to moderate depression or sleep problems will use the app for a few weeks. The app provides relaxation exercises, m…

This study tests a program called CommunityRx-Dementia, where trained peer mentors help caregivers of people with dementia. Over 12 months, caregivers get a personalized list of community resources, coaching, and supportive text messages. The goal is to reduce loneliness and help…

This study will test whether sacral massage (a massage on the lower back) can help reduce pain, depression, stress, and anxiety during labor. About 193 first-time mothers with a single, healthy baby will be randomly assigned to receive the massage or standard care. Researchers wi…

This early-phase study tests whether a shortened LSD experience, combined with the drug risperidone, can safely ease symptoms of major depression. Ten adults with moderate to severe depression will receive LSD followed by risperidone 45 minutes later. Researchers will monitor saf…

This study tests a wearable light device (Vielight RX Gamma) that shines light on the brain to see if it safely eases bipolar depression symptoms. Forty people with bipolar disorder will either get the active device or a sham (inactive) one, using it in the clinic 5 days a week f…

This study tests a brain stimulation treatment called TMS to help female athletes with both depression and concussion symptoms. About 35 women aged 18-65 who have had a concussion and have moderate to severe depression will receive the treatment. The goal is to see if TMS can imp…

This study will test whether doing Pilates exercises at home via video calls for 16 weeks can help people with multiple sclerosis (MS) walk farther and faster, improve balance, reduce fatigue and pain, and boost mood and thinking. About 50 adults with mild to moderate MS who can …

This study tests whether intradermal acupuncture (tiny needles left under the skin for days) can help people with depression safely reduce or stop their SSRI medication. 114 adults planning to taper off SSRIs will be split into three groups: tapering alone, tapering with sham acu…

This study will test whether adding a mental health app called TREE-Connect to remote therapy sessions helps reduce depression in adults aged 50 to 80. Sixty participants with mild-to-moderate depression will use the app and attend therapy remotely. The main goal is to see if peo…

This study tests whether an 8-week mindfulness-based psychoeducation program can reduce depression symptoms, improve stress tolerance, and help with emotion regulation in adults diagnosed with major depression. About 70 outpatients aged 18-65 who have been treated for depression …

This study tests whether electroacupuncture (a type of acupuncture with mild electrical pulses) can reduce a group of common symptoms—pain, tiredness, sleep problems, anxiety, depression, and memory fogginess—in breast cancer survivors who are on hormone therapy. About 228 women …

This study will test an internet-based therapy program for people with emotional disorders like depression and anxiety. The program teaches skills to manage emotions and is designed to be used at home. Researchers want to see if it works well in primary care settings, if it is co…

This study looks at how well and safely the antidepressant escitalopram works in people experiencing their first episode of major depression who have never taken medication for it. Two hundred adults aged 18 to 65 will take escitalopram for 8 weeks, and researchers will track the…

This study tests a device that gently stimulates a nerve in the ear during heart surgery. The goal is to see if it lowers the chance of postoperative delirium, anxiety, and depression. About 270 adults having elective heart surgery will be randomly assigned to receive real or sha…

This study tests whether playing a virtual reality music-movement game can improve mood and social connection in young adults aged 18-25 with mild to moderate depression or anxiety. Participants will be split into three groups: one playing a social VR game with others, one playin…

This study tests a non-drug treatment called transcranial electrical stimulation (tES) for people who have both depression and chronic pain. 240 adults will receive one of four types of brain stimulation or a fake treatment for two weeks. Researchers will check if it reduces pain…

This study tests whether empagliflozin, a drug used for diabetes, can help reduce depression in people with bipolar disorder who also have insulin resistance. Twenty adults with bipolar depression will take the drug for 12 weeks alongside their usual treatment. The goal is to see…

This study tests whether using a virtual reality headset for 30 minutes each week can reduce depression in teenage girls aged 13-18. Half the participants will use VR, while the other half take standard antidepressant pills. Researchers will measure changes in depression scores a…

This study aims to see if acupuncture is more effective than a placebo for treating major depression. Researchers will compare acupuncture to the antidepressant escitalopram in 216 adults who are not currently taking any depression medication. The goal is to find out if this anci…

This study tests whether a device that gently stimulates a nerve in the ear (taVNS) during breast cancer surgery can help prevent or reduce negative emotions like anxiety and depression after the operation. About 232 women will receive either real or sham stimulation for 30 minut…

This study tests a structured psycho-social program (PSP) for adults aged 30-40 with type 2 diabetes who have mild-to-moderate mental health issues. Over 6-8 sessions, participants learn to manage stress, challenge negative thoughts, and improve daily habits. The goal is to reduc…

This pilot study will test a type of brain stimulation called accelerated intermittent theta-burst stimulation (a-iTBS) in 45 adolescents aged 12-18 with major depressive disorder. Participants will get either real or sham stimulation, guided by MRI scans. The goal is to see if i…

This study tests whether an 8-week psychoeducation program, based on Acceptance and Commitment Therapy, can help people with depression feel more meaning in life and take better care of themselves. About 46 adults receiving TMS treatment will either join the program or continue u…

This study looks at whether craniosacral therapy, a gentle manual therapy, can reduce pain, depression, and improve body awareness and quality of life in primary caregivers of people with special needs. About 30 female caregivers aged 18-55 will either receive the therapy or be i…

This study tests whether a Mediterranean diet, adapted for Hong Kong, can reduce depression symptoms in 90 adults with moderate to severe depression. Participants will receive meal deliveries and track their mood and diet via phone surveys. The study also looks at how gut bacteri…

This study tests an enhanced version of depression treatment (COMBEX) for youth aged 15-24 with HIV. It combines therapy, medication management, and extra support strategies to improve mood and HIV care. Researchers will compare it to standard combination therapy over 72 weeks in…

This study tests a program called REWIRE for teens aged 12-17 who feel anxious or depressed and use social media over 3 hours daily. The program aims to cut social media use by about half and replace it with positive offline activities like hobbies or time with friends. Researche…

This pilot study will test a 'blended' therapy approach for adults with emotional disorders like anxiety and depression. Participants will either receive standard face-to-face therapy, a mix of face-to-face sessions and a smartphone app, or be placed on a waitlist. The goal is to…

This study tests whether using a person's brain scan (MRI) to guide TMS treatment for depression works better than the standard scalp-measurement method. 160 adults with major depression will receive accelerated TMS (10 sessions a day for 5 days) with either MRI or scalp targetin…

This study tests whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can improve memory and thinking in people with bipolar disorder. The trial will involve 88 adults with bipolar disorder who are currently stable. They will receive e…

This study tests whether a dietary supplement called GynMDD, taken alongside weekly supportive therapy, can improve symptoms of mild to moderate depression more than therapy plus a placebo. 168 adults aged 18 to 65 will take either the supplement or a placebo daily for 8 weeks, c…

This study explores whether 8 weekly telehealth music therapy sessions can improve quality of life and reduce depression and anxiety in adults with autoimmune endocrine diseases (like Type 1 diabetes or Hashimoto's) who also have depression. Ten participants will meet with a boar…

This study looks at whether a program combining yoga, meditation, and mindful eating can lower stress, anxiety, and depression in university students. Sixty students will attend weekly sessions for a semester and fill out questionnaires to measure changes. The goal is to see if t…

This study tests whether a community-based programme can improve well-being and reduce loneliness in adults aged 55 and older who have mild depression symptoms. 300 participants will be randomly assigned to either an 8-week programme of well-being sessions and follow-up support, …

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with therapy is safe and helpful for people who have both major depression and alcohol use disorder. Thirty adults will receive either psilocybin or a placebo, along with therapy sessions. The…

This study tests whether a mental health app called Intellect can reduce depression and improve resilience in medical students. 220 students will be split into two groups: one gets full app access, the other gets basic access. Researchers will check changes in mood, anxiety, and …

This study tests a safe, non-invasive therapy that uses gentle pressure on the arms to improve sleep and mood in people who have had a stroke and suffer from insomnia. The treatment, called remote ischemic adaptation, aims to help the brain recover by briefly restricting and rest…

This study tests a new approach where general practitioners and pharmacists work together to help adults who have been taking antidepressants for a long time but are feeling stable. The goal is to see if this teamwork helps more people safely stop their medication without their d…

This study will test a one-day acceptance and commitment therapy (ACT) program for 50 veterans who have both inflammatory bowel disease (IBD) and a mental health condition like depression, anxiety, or PTSD. The goal is to see if this brief therapy can improve their quality of lif…

This study will test two types of exercise—high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT)—in 68 healthy young adults aged 18 to 21. Over 8 weeks, researchers will measure changes in cardiorespiratory fitness, testosterone and cortisol le…

This study tests whether a single 'Braining' group exercise session can quickly reduce anxiety in people receiving psychiatric care. Thirty participants will rate their anxiety before and after the session. The goal is to see if exercise can be a fast-acting tool to ease symptoms…

This study tests whether adding a ketogenic (low-carb) diet to a non-invasive brain stimulation treatment called iTBS helps people with treatment-resistant depression feel better. Sixty adults will follow either a keto diet or a standard healthy diet for three weeks, then receive…

This study looks at whether community health workers (CHWs) can effectively provide a mental health program to Spanish-speaking Latine parents who have symptoms of depression, anxiety, or traumatic stress. About 52 parents will either get the program right away or after a 5-month…

This study tests whether a gentle hand-application method called Jin Shin Jyutsu can help perimenopausal women feel better emotionally and physically. Sixty women aged 40-54 will practice the technique daily for two weeks. Researchers will measure changes in quality of life, stre…

This study tests whether mothers singing lullabies while bathing their newborns can strengthen bonding, reduce postpartum depression symptoms, and boost parenting confidence. About 98 healthy mothers and their full-term babies will take part. Half will bathe their baby three time…

This study tests whether EMDR group therapy can help adults who experienced the April 2025 Silivri earthquake in Turkey. Forty participants will be randomly assigned to either the therapy group or a waitlist. Researchers will measure changes in PTSD, depression, anxiety, sleep qu…

This study tests whether internet-based group cognitive behavioral therapy (CBT) delivered over Zoom can reduce symptoms of anxiety and depression in international students in Malaysia. About 128 students with moderate to severe symptoms will be randomly assigned to either the th…

This study tests whether a single low dose of esketamine, given during anesthesia for breast cancer surgery, can reduce severe depression and anxiety symptoms right after the operation. Researchers will enroll 242 women with severe depression who are scheduled for breast cancer r…

This study tests whether giving esketamine continuously during breast cancer surgery can reduce feelings of anxiety and depression after the operation. About 218 women having breast cancer surgery will be randomly assigned to receive either esketamine or a placebo during anesthes…

This study looks at whether giving esketamine continuously during breast cancer surgery can reduce feelings of anxiety and depression in patients who already have mild-to-severe depression. About 142 women will take part, and their mood and sleep quality will be tracked after sur…

This study tests if the drug lumateperone can reduce depression symptoms in adults aged 21 to 70 who have major depressive disorder and a history of early life trauma. Half of the 50 participants will get the drug, and half will get a placebo, with results measured after 6 weeks.…

This study tests a special type of acupuncture—dense cranial electroacupuncture plus body acupuncture—in 148 teens aged 15-22 with mild to moderate anxiety or depression. Participants receive treatment twice a week for 8 weeks, and researchers measure changes in anxiety, depressi…

This study tests a daily digital mindfulness program designed to reduce depressive symptoms in people who have completed treatment for breast, prostate, or colorectal cancer. Researchers will enroll 76 participants with mild to moderate depression to see if the program is feasibl…

This study aims to see if peer support can help pregnant and postpartum veterans who have serious mental illness. Researchers will develop a program where trained peer specialists offer support, then test it with 24 veterans to see if it is helpful and practical. The goal is to i…

This study tests a new computer task that trains your eye movements to help treat major depression. The task uses a gaze-contingent feedback system to retrain attention patterns. Researchers will enroll 60 adults with depression to see if this approach reduces symptoms. The goal …

This study tests whether a special type of acupressure—timed to the body's natural daily rhythms—can improve sleep in nursing home residents aged 60 and older. Eighty participants will receive either real or fake acupressure twice a day for four weeks. Researchers will measure sl…

This pilot study will test whether a smartphone app that teaches cognitive behavioral therapy for insomnia (CBTI) can improve sleep in 144 active-duty service members. Participants will use the app for five weeks, and researchers will measure changes in insomnia severity, depress…

This study tests whether listening to positive self-affirmation audio recordings can help reduce pain, depression, anxiety, and stress in women who have had a mastectomy. Forty-two women will be randomly assigned to either listen to the affirmations or receive standard care. The …

This study tests whether adding virtual reality (VR) sessions to standard counseling helps university students with public speaking anxiety more than counseling alone. About 72 students will be randomly assigned to either counseling only or counseling plus VR exercises that simul…

This study tests whether metformin, a standard diabetes drug, can help treat depression in people living with HIV. Researchers will enroll 600 adults with HIV and depression, giving them metformin, fluoxetine (a standard antidepressant), both, or a placebo for up to 12 weeks. The…

This study tests a new visual safety plan designed for autistic teenagers who have had suicidal thoughts or self-harm. About 90 teens aged 13-18 will be randomly assigned to either get the visual plan plus usual care, or just usual care. The goal is to see if the plan is easy to …

This Phase 1 trial is the first time SP-101 is being tested in humans. It will enroll 80 healthy adults to check the drug's safety, tolerability, and how the body processes it. SP-101 works by blocking NMDA receptors in the brain, a different approach from standard antidepressant…

This study tests whether a simple art activity—coloring mandalas—can reduce anxiety and depression in new mothers. Sixty women who recently gave birth will be randomly assigned to either practice mandala coloring at home for eight weeks or receive standard postpartum care. Resear…

This study will test a smartphone app called CONEMO in over 12,000 adults visiting primary care clinics. The app uses cognitive behavioral therapy techniques to help reduce symptoms of depression, anxiety, and insomnia. Participants will use the app on their own phones or tablets…

This study will test if a program combining supervised exercise and perineal massage during pregnancy can help prevent problems like urinary incontinence, depression, and gestational diabetes. About 2000 healthy pregnant women will be randomly assigned to either the program or us…

This study looks at whether therapeutic gardening can help teenagers with depression who harm themselves. 66 teens will take part in gardening activities like planting and caring for plants. The goal is to see if this reduces self-harm, improves mood, and helps with sleep and lon…

This Phase 2 trial will test whether adding selenium supplements to standard antidepressant medication (fluoxetine) can improve depression symptoms in 172 children and adolescents aged 12-18 with major depressive disorder. Participants will receive either selenium or a placebo fo…

This study tests whether mindfulness-based cognitive therapy (MBCT), adapted for Vietnamese culture, can reduce depression symptoms and improve quality of life. One hundred sixty adults with mild-to-moderate depression will be recruited from eight Buddhist pagodas near Hanoi. Hal…

This study will test an adapted form of cognitive behavior therapy (CBT) in 80 adults aged 18–50 who have had multiple episodes of major depression. The therapy is designed to help people manage depression and anxiety, improve quality of life, and build skills to prevent future e…

This study tests whether very short (4 or 8 sessions) psychological treatments can reduce symptoms of anxiety, depression, and stress-related physical complaints. About 184 adults with mild to moderate symptoms will be randomly assigned to group or individual therapy, or a relaxa…

This study tests a new method of delivering repetitive transcranial magnetic stimulation (rTMS) for people with treatment-resistant depression. Instead of the standard approach, the new method uses brain surface mapping to target a specific area. The trial will compare the two me…

This study tests whether increasing ward rounds from twice to four times a day, with structured conversations and simple breathing exercises, can lower anxiety in hospitalized patients waiting for therapeutic gastrointestinal endoscopy. About 1,000 adults with mild anxiety will t…

This study tests a device that sends gentle electrical currents to the brain, automatically adjusting to your brain's own rhythms, to ease depression symptoms. It involves 214 adults who have tried at least one antidepressant without enough relief. Participants will receive eithe…

This Phase 3 trial tests whether inhaling nitrous oxide (laughing gas) can reduce depression symptoms in 120 adults with treatment-resistant major depressive disorder. Participants will receive either nitrous oxide plus a placebo or oxygen plus a mild sedative, and their mood wil…

This study tests whether a digital mental health platform with open peer support can improve quality of life in adults with mild anxiety or depression symptoms. 82 participants will use the platform for 31 days. The goal is to see if their overall well-being, stress, and mood imp…

This pilot study tests whether a one-day online cognitive behavioral therapy (CBT) workshop can help women with postpartum depression in Türkiye. Sixty mothers with depressive symptoms will be randomly assigned to either the workshop or usual care. The study focuses on whether th…

This study tests whether using a virtual reality headset during a breast biopsy can lower depression, anxiety, and stress. 80 women will either wear a VR headset showing calming nature scenes or receive standard care. Researchers will measure their mood before and after the proce…

This study tests a non-invasive brain stimulation technique called iTBS to help ease depression in young women aged 16 to 24. Eight female participants will receive the treatment to see if it improves mood and brain function. The goal is to find a new way to reduce depression sym…

This study tests a program that combines doctor care, digital tools, virtual reality, and school-based support to help teens and adults in Morocco with depression and anxiety. About 146 participants will be split into two groups: one gets the new program, the other gets usual car…

This study tests whether a short, intensive psychological program before lung cancer surgery can lower anxiety and depression. About 138 adults scheduled for lung cancer surgery will be split into three groups: one receiving four weekly therapy sessions, one refusing support, and…

This study tests a guided self-help CBT manual called 'Khushi or Khatoon' for cancer patients with anxiety and depression. The manual uses culturally adapted stories and exercises over eight weeks. Researchers will enroll 108 adults in Pakistan to see if the manual is feasible, a…

This study tests if adding exercise and education to standard talk therapy helps people with depression feel better. About 112 adults will be split into two groups: one gets therapy alone, the other adds an 8-week program of guided exercise and learning sessions. Researchers will…

This study tests whether a version of dialectical behavior therapy (DBT) that has been adapted to fit local cultures can help adults aged 18-45 with borderline personality disorder better manage their emotions and reduce self-harm. The therapy is being studied in a low- and middl…

This pilot study tests whether a daily lemon balm supplement can improve mood and reduce stress in healthy adults. Forty volunteers will take either the supplement or a placebo for 3 weeks. Researchers will measure changes in stress perception and cortisol levels.

This study tests whether structured group therapy, including cognitive behavioral therapy and mindfulness, can reduce symptoms of depression and anxiety in adults in Pakistan. About 108 participants will attend 12 weekly group sessions. The goal is to see if this approach improve…

This study will test if using an AI chatbot like ChatGPT can help people with generalized anxiety disorder or major depressive disorder who are already in regular therapy. Researchers plan to recruit 204 adults in the U.S. who are currently in individual therapy. Participants wil…

This study looks at whether teaching mindfulness skills to pregnant women admitted to the hospital for risk of preterm delivery can reduce their depression, anxiety, and stress. Researchers will enroll 60 mothers and provide four weeks of mindfulness training. Participants will f…

This study will test a program called Living Well, which includes a mobile app with 21 mental health modules and personal coaching sessions, for breast cancer patients with moderate to severe anxiety. The goal is to see if the program can lower anxiety and reduce overall healthca…

This study tests a brain-training method called neurofeedback to see if it can help people with obsessive-compulsive disorder (OCD) and post-traumatic stress symptoms feel better overall. Twenty adults on a therapy waitlist will try the training, and researchers will check for ch…

This study tests whether a generative AI chatbot can help new mothers learn about pelvic floor health and reduce feelings of loneliness after childbirth. Researchers will compare standard postpartum care with or without access to the chatbot over 4 weeks. The trial involves 130 f…

This study will test a mobile app designed to help veterans who have both PTSD and depression. The app teaches skills to manage emotions and relationships, based on a proven talk therapy. Forty veterans will use the app and answer surveys to see if it improves their daily functio…

This study tests whether a digital monitoring device called Dalia can improve depression symptoms when added to usual care. About 644 adults with moderate-to-severe depression will use the device for 3 months. The main goal is to see if more people feel significantly better compa…

This phase 2 trial tests whether adding the antidepressant trazodone to psilocybin can reduce the intense psychedelic effects while keeping the mood-lifting benefits. 112 adults with treatment-resistant depression will receive either psilocybin alone, psilocybin plus a low or hig…

This study tests an 8-session psychoeducational program called 'Key to Emotional Balance' for adults with bipolar disorder. The program uses positive psychotherapy to help people better regulate their emotions, support recovery, and find more meaning in life. Researchers will com…

This study combines virtual reality with a gentle electrical pulse on the ear (called taVNS) to help people with chronic shoulder pain who are waiting for surgery. The goal is to see if this drug-free approach can reduce pain, anxiety, and depression. Only 10 people will take par…

This study tests a self-help program for 200 post-9/11 veterans who have depression or PTSD symptoms but are not in therapy. The program teaches healthy coping skills and how to find support services. Researchers will compare the self-help group to those receiving standard resour…

This study tests whether acupuncture can reduce anxiety and depression in women with breast cancer. Researchers will compare real electroacupuncture to a sham version in 360 participants. The goal is to see if this needle-based therapy improves emotional well-being without medica…

This study tests whether an 8-week internet-based cognitive behavioral therapy (ICBT) program can help adults with generalized anxiety disorder or major depressive disorder. Participants in Taiwan will either receive standard care alone or standard care plus the online program, w…

This study will test if art therapy sessions can lower anxiety and disease severity in 48 adults hospitalized in a psychiatry ward. Participants will be randomly assigned to receive art therapy plus standard care or standard care alone. The goal is to see if creative expression c…

This pilot study tests whether a non-invasive device that sends a mild alternating current to the brain (tACS) can safely ease depression symptoms in 30 teenagers who have never taken antidepressants. Participants will receive daily sessions over several weeks, and researchers wi…

This study tests whether bupropion hydrobromide (Aplenzin) can safely ease depression symptoms in children and adolescents aged 7 to 17. About 246 participants will receive either the drug or a placebo. The main goal is to see if depression scores improve by the end of treatment.

This study will test whether taking a break from digital devices and social media can help reduce depression, anxiety, stress, and improve sleep quality in young adults. One hundred participants who use social media at least 8 hours a day will be randomly assigned to a digital de…

This study is testing a virtual reality (VR) platform designed to help first-time pregnant women prepare for childbirth and improve their mental wellbeing. The VR program includes education about childbirth and exercises to build coping skills and confidence. Researchers will com…

This study compares an AI-powered orientation program to one given by human nurses for patients in the intensive care unit (ICU). The goal is to see if the AI program helps patients have more days without delirium, lowers anxiety and depression, and shortens their hospital stay. …

This study tests a blackcurrant-based drink called Ārepa to see if it helps thinking and mood during simulated high altitude (4,500 meters). Twenty-seven healthy men will take the drink or a placebo in random order, then do thinking tasks and have their heart rate, oxygen levels,…

This study tests whether low-dose laser acupuncture (LLA) can safely improve sleep in 120 adults with major depressive disorder and insomnia. Participants will receive either real or sham laser acupuncture five times a week for six weeks, while continuing their usual depression m…

This study tests whether a 10-minute daily virtual reality session can improve mood in people with seasonal affective disorder (SAD), compared to the standard 30-minute light box therapy. Sixty adults with moderate to severe SAD will use either VR or a light box every day for two…

This study compares two add-on treatments—esketamine nasal spray and aripiprazole pills—for older adults (60-74) whose depression hasn't improved with standard antidepressants. Around 220 participants will receive either esketamine once or twice weekly or daily aripiprazole, alon…

This study will test whether video-guided mindfulness exercises can help reduce depression symptoms and improve quality of life in 120 pregnant women in Ethiopia. Participants will attend a health center three times a week for eight weeks to listen to guided mindfulness sessions.…

This trial is testing a device that has not been approved by the U.S. FDA. The purpose is to gather information about how the device works in people. Participants will be monitored for safety and any effects. The study is still ongoing, and details about who can join are not yet …

This study looks at whether learning about well-being can improve how romantic partners think and feel. About 2,000 couples with mild depression symptoms will take online surveys about their emotions and relationship satisfaction. The goal is to see if gaining knowledge about wel…

This study tests a new program called CapExchange, where people with stable mental health conditions exchange practical skills with others in their community. The goal is to see if this approach is practical and helpful for improving well-being and social connection. About 10 to …

This study looks at how emotional childhood maltreatment (like verbal abuse or neglect) affects social skills, brain structure, and inflammation in people with bipolar disorder. Researchers will compare 80 people with bipolar disorder and 80 healthy controls, using brain scans, b…

This study looks at how a non-invasive brain stimulation technique called intermittent theta burst stimulation (iTBS) affects symptoms and blood markers in people with treatment-resistant depression. Fifty patients will receive iTBS sessions over four weeks, while fifty healthy v…

This study looks at how exercise affects a natural cell cleanup process called autophagy, which may be linked to depression. Researchers will have 120 healthy adults do a cycling test and take blood samples to measure changes in autophagy and related genes. The goal is to better …

This study will examine whether certain RNA molecules in the blood are different in people with psychiatric disorders like schizophrenia, depression, bipolar disorder, OCD, and panic disorder. Researchers will compare these molecules in patients who are not currently on medicatio…

This study aims to adapt and validate a French version of the Recovery Assessment Scale (RAS), a questionnaire that measures how people feel about their own recovery from mental health conditions. Researchers will ask 260 adult psychiatric patients in France to fill out the RAS a…

This study will measure how different types of transcranial magnetic stimulation (TMS) change brain activity in 250 military veterans with major depressive disorder. Researchers hope to use this information to develop more personalized brain stimulation treatments. Participants w…

This study tests whether nurses can accurately identify depression in people on hemodialysis. About 450 patients will have their depression symptoms assessed both by a nurse and by themselves using a standard questionnaire. The goal is to see if nurse assessments can be a reliabl…

This study will follow 45,000 university students over three years to understand how financial struggles, housing issues, and loneliness affect their mental health and whether they seek help. Participants will fill out questionnaires about their well-being and life circumstances.…

This study looks at better ways to screen caregivers of people with dementia for depression and connect them to online treatment. About 15 adult caregivers who show mild depression symptoms will test a new app. The goal is to see if the approach is easy to use and helps more peop…

This study will test the long-standing theory that depression is caused by low serotonin levels in the brain. Researchers will give a single dose of fenfluramine (a drug that releases serotonin) to 46 people—half with depression and half healthy—and use PET brain scans to measure…

This pilot study will examine whether certain genes related to serotonin are linked to gut bacteria that process tryptophan in adults with depression, anxiety, PTSD, or panic disorder. Thirty participants will provide saliva and stool samples from home. The goal is to gather info…

This study will give 20 healthy adults a single dose of psilocybin (the active ingredient in magic mushrooms) to see how it changes mood and well-being. Some participants will also get a drug called pimavanserin beforehand to help understand which brain receptors are involved. Th…

This study will use advanced brain scans to see how a quick, 3-minute form of magnetic brain stimulation changes the brain in people with major depression. Twenty adults will receive one week of treatment and have PET and MRI scans before and after. The goal is to understand the …

This study uses a virtual reality task to measure how people with depression make decisions involving physical effort and reward. Participants will walk on a treadmill in a VR environment while researchers track brain activity, heart rate, and energy use. The goal is to better un…

This observational study will follow 140 women after vaginal delivery to see if using epidural pain relief during labor is linked to better postpartum recovery and mother-infant bonding. Researchers will use questionnaires to measure recovery quality and bonding in the first day …

This study looks at whether a single dose of modafinil or D-serine can improve decision-making and thinking in people who have had psychosis for less than five years. Twenty-four participants will play computer brain games and have brain scans before and after taking the drugs. T…

This study looks at how acupuncture might quickly improve symptoms of depression and uses brain scans to understand why. Researchers will enroll 80 adults with mild to moderate depression who will receive acupuncture treatment. Before and after treatment, participants will have b…

This study will survey 385 women who gave birth within the past 4 weeks to 12 months to understand how often postpartum depression occurs and how it relates to body image dissatisfaction, self-objectification, and comparing appearances on social media. Participants answer online …

This study looks at 130 people with major depression who have suicidal thoughts. Researchers will use brain scans, genetic tests, and other biological measures to see how rapid treatments like Esketamine and electroconvulsive therapy (ECT) change the brain. The goal is to find ea…

This study aims to adapt a digital mental health app called Wysa for adolescent girls aged 13-18 in rural Uttar Pradesh, India, who have anxiety or depression. Researchers will work with the girls, their families, and community members to identify what helps or hinders app use an…

This study aims to understand how a quick, non-invasive brain stimulation treatment called iTBS works in people with depression. Researchers will measure brain activity before and after stimulation in 100 participants (healthy volunteers and those with depression) using EEG and M…

This study looks at whether recommending bed rest to pregnant women with a short cervix actually helps prevent preterm birth. Researchers will compare women who are told to rest with those who continue normal daily activities. The goal is to see if avoiding bed rest is just as sa…

This study will enroll 500 adults with high levels of repetitive negative thinking (like worry or rumination) to understand why cognitive-behavioral therapy helps. Participants will receive one of two digital therapy programs: one focusing on concrete thinking, the other on self-…

This study tests whether adding a career counseling program called Purposeful Pathways to standard job training helps veterans with mental health and substance use disorders find and keep quality jobs. About 254 veterans from three VA sites will take part. The goal is to improve …

This study compares screening for postpartum depression at 2 weeks after birth versus the usual 6-8 weeks. Researchers will randomly assign 428 new mothers to either early or routine screening using a simple questionnaire. The goal is to see if earlier screening helps identify de…

This observational study will survey over 300 Ukrainian women to understand how war influences their decisions about pregnancy and childbirth, and their mental health during the perinatal period. Participants will complete questionnaires about their well-being, reproductive choic…

This study will use brain scans (MEG and MRI) to look at brain activity in 60 young people aged 14-24 who have either attempted suicide, have ongoing suicidal thoughts, or are healthy. The goal is to find brain patterns linked to suicide risk. High-risk participants will also rec…

This study looks at how heart rate variability (a measure of stress response) relates to emotional control and parent-teen relationships in 74 adolescents with depression. Teens will wear a Fitbit while sleeping for a week and fill out questionnaires. The goal is to better unders…

This study will test ways to improve how doctors choose electroconvulsive therapy (ECT) stimulation settings for people with severe depression or catatonia. Researchers will use real-time brain monitoring to measure brain activity and blood flow during ECT. The goal is to find th…

This study tests a new way to monitor muscle activity during electroconvulsive therapy (ECT) for depression, bipolar disorder, or schizophrenia. It compares a standard arm tourniquet method with a newer, potentially less painful technique. The goal is to see if the new method wor…

This study looks at how natural hormone changes during the menstrual cycle may make some teenage girls more irritable or depressed, especially those at risk for suicide. Researchers will give 50 girls ages 12-16 either a birth control pill to keep hormones steady or a placebo for…

This study follows 120 people with laryngeal cancer to see how their quality of life, voice, swallowing, pain, and mood change before treatment and at 3, 6, and 12 months after. Researchers will use questionnaires to track these changes. The goal is to better understand recovery …

This observational study will test whether a 1-3 minute AI-powered facial scan can accurately measure vital signs like heart rate and blood pressure, as well as estimate blood sugar, cholesterol, and mental health status. Researchers will compare the scan results with standard me…

This study looks at how anxiety and depression influence shared decision-making in patients aged 65 and older with critical limb threatening ischaemia (CLTI), a severe form of leg artery disease. Researchers will interview patients, their carers, and healthcare staff to understan…

This study tests whether a brain stimulation treatment for depression called iTBS can be improved by customizing it to each person's brain signals. Researchers will use EEG to measure brain responses and find the best stimulation settings for 80 adults with treatment-resistant de…

This study will use a brain imaging technique called fNIRS to see how electroconvulsive therapy (ECT) and magnetic seizure therapy (MST) change brain activity in people with major depression. Researchers will compare the two treatments in 60 adults to understand their effects on …

This study tests a group program to help veterans with serious mental illness feel more comfortable and confident working with their doctors and therapists. About 119 veterans from three VA centers will take part. The goal is to see if the program improves teamwork between vetera…

This study tests whether using a person's genetic information can help doctors choose the best antidepressant for major depressive disorder. 570 adults in Morocco will be randomly assigned to either genetic-guided treatment or standard care. Researchers will track depression symp…

This study looks at whether using a conversational AI to collect medical history can make people with depression feel more understood by their doctors. About 130 adults with moderate to severe depression will try the AI at home before a regular visit and rate how empathetic the e…

This study tests a computer tool that uses artificial intelligence to alert doctors when a pregnant patient may be at high risk for postpartum depression. The tool gives doctors a risk score and suggests steps like referrals or educational materials. Researchers will ask 160 preg…

This study will use brain scans and thinking tests to compare how people with bipolar disorder and major depression control their impulses. Researchers want to find differences in brain activity that could help doctors make a more accurate diagnosis. The study involves 120 adults…

This study explores whether simple eye tests (electroretinography) can predict how well a person with major depression will respond to common antidepressants. Researchers will measure electrical signals from the eyes of 108 participants before and after starting medication. The g…

This study looks at how ketamine, a drug already used for depression, might reduce suicidal thoughts by affecting stress-related brain pathways. Researchers will give 12 adults with major depressive disorder a single ketamine infusion, then use smartphone tracking and PET brain s…

This study looks at how different treatments for depression—medication, talk therapy, or both—change the way symptoms like sadness, sleep problems, and low energy are connected. Researchers will track 90 adults with mild to moderate depression using smartphone surveys to see whic…

This study is testing a program called Mothers and Babies for Down Syndrome (MBDS) to help prevent depression in new and expectant parents of infants with Down syndrome. About 72 parents will take part in a small pilot study to see if the program helps with feelings of grief and …

This study will test a tool called the Health Improvement Profile (HIP) in a mental health inpatient unit. The HIP is a checklist that helps clinicians spot physical health problems like high blood pressure or poor diet in people being treated for mental illness. Researchers will…

This study looks at whether a simple eye test can predict how well people with treatment-resistant depression will respond to a brain stimulation therapy called TMS. Researchers will measure how the pupils react to light before and after TMS treatment in 44 adults. The goal is to…

This study looks back at data from 80 veterans and first responders who completed a 12-week program that combined mental health support, physical therapy, nutrition advice, and occupational therapy. Researchers want to see if the program helped improve sleep, anxiety, depression,…

This study aims to find biological markers that predict how well people with major depressive episodes respond to light therapy. Researchers will treat 173 adults with unipolar or bipolar depression using a bright light box for 4 weeks. By measuring sleep, mood, and circadian rhy…

This study compares a new selegiline skin patch to an existing one (EMSAM®) to see how well the skin tolerates it. Researchers will apply both patches to 230 healthy adults and check for irritation or allergic reactions. The goal is to ensure the new patch is safe for the skin be…

This research looks at how brain networks relate to thinking and memory problems in people with schizophrenia, bipolar disorder, or major depression. The goal is to use brain imaging to better assess cognitive issues, improve diagnosis, and predict how well treatments might work.…

This study looks at how physical activity levels are linked to posture, sleep quality, depression, and muscle or joint pain in health science professors and researchers at Istanbul Aydin University. About 73 academics aged 23 to 65 will fill out questionnaires. The goal is to und…

This study looks at how six short, 15-minute self-regulation techniques — like exercise, breathing, aromatherapy, music, virtual reality, and tapping — affect the body and brain of one woman with ADHD and stabilized bipolar disorder. Researchers will measure heart rate, brain wav…

This study will use brain scans to see how cognitive behavioural therapy (CBT) affects the brains of 30 people aged 40-60 with major depression. Participants will receive 12 weeks of CBT, with follow-ups up to 9 months. The goal is to understand how CBT improves mood and thinking…

This study aims to find out how common depression is among medical students at Sohag University. Researchers will survey 300 students aged 18 to 25 to measure depression rates and understand the factors that contribute to it. The goal is to raise awareness and improve mental heal…

This study aims to find better ways to diagnose bipolar disorder and predict when mood episodes might happen. Researchers will track sleep, activity, and decision-making in 600 people with bipolar disorder, major depression, or healthy controls using smartwatches and computer tas…

This study is creating a decision-support tool called CRAFTT to help therapists tailor mental health treatments to the cultural values and experiences of Latine youth (ages 5-15). The goal is to improve how well these treatments work and reduce mental health disparities. Research…

This study looks at how two types of noninvasive brain stimulation affect brain activity and the body's stress system in people with both PTSD and major depression. Fifty adults will receive both active and sham stimulation in random order, with brain and heart measurements taken…

This study looks at whether a tailored exercise program can improve how quickly muscles recover oxygen after activity in menopausal women with depression. Researchers will compare exercise to a non-physical activity in 52 women. The goal is to understand the link between depressi…

This study aims to find better ways to treat depression by testing two ideas: whether having therapy twice a week instead of once leads to better results, and whether matching the type of therapy (CBT or psychodynamic) to a person's personality helps. Researchers will enroll 200 …

This study looks at how mental state, emotional eating, and sleep quality together influence the risk of metabolic syndrome (a cluster of conditions like high blood pressure and blood sugar) in people with schizophrenia or bipolar disorder. Researchers will measure these factors …

This study aims to better understand psychiatric disorders, thinking problems, and treatment side effects in 2000 cancer patients and their close relatives. Researchers will compare those with and without mental health issues to find patterns and improve care. No new treatments a…

This study looks at whether video or phone calls with a breastfeeding counselor can help first-time mothers breastfeed longer, feel more confident, and have fewer symptoms of postpartum depression. About 100 new moms will either get standard care or extra telehealth support. The …

This study tests a new digital health tool designed to help adults aged 40 and older who have two or more long-term health conditions, like high blood pressure, diabetes, or depression. The tool includes an electronic system to guide doctors, telemedicine for specialist visits, a…

This study looks at how S-ketamine, a treatment for severe depression, affects tiny energy centers (mitochondria) in blood cells. Researchers will take blood samples from 30 adults with treatment-resistant depression before and after treatment. They hope to find markers that pred…

This study compares two strategies for safely stopping antidepressants in adults whose depression is in remission. Participants will be randomly assigned to either a standard gradual dose reduction or a more precise hyperbolic tapering method. The goal is to see which approach le…

This study follows 160 adults in Hong Kong over time to see if disruptions in daily activity and sleep (rest-activity rhythms) can predict who develops major depressive disorder. Participants will wear activity monitors and complete questionnaires about mood and sleep. The goal i…

This study will test an enhanced version of a suicide safety planning app called ViraSafe in 100 teens and young adults (ages 13-24) who have recently attempted suicide or had serious suicidal thoughts. The goal is to see if the app helps them engage more with coping skills and t…

This study will analyze data from 500 adults to see if depression and asthma are connected, and if one might cause the other. Researchers will use medical records and genetic information to identify factors like age, smoking, or weight that could influence the link. No new treatm…

This study tests whether a smartphone app, co-created with teens, plus trained peer navigators can help more young people ages 13-22 get mental health care in schools and clinics. Over 8,000 youth will take part across multiple sites. The goal is to see if this approach increases…

This study looks at whether teaching people in the hospital about their psychiatric medications helps them stick to their treatment and handle side effects. Researchers will work with 64 adults who have serious mental illnesses like schizophrenia or bipolar disorder. The goal is …

This study will check how much psychiatric clients know about occupational therapy (OT) and whether their expectations are realistic. It will also evaluate how well OT interns explain health information and conduct interviews. Researchers will develop new tools to measure these s…

This observational study looks at whether some teenage girls with depression are especially sensitive to natural changes in estrogen and progesterone. About 94 participants will track their hormone levels daily at home and answer mental health surveys for 90 days. The goal is to …

This study aims to develop a brain wave (EEG) test that can measure how ketamine affects depression symptoms. Researchers will give ketamine infusions to 20 adults with treatment-resistant depression and track changes in their mood and brain signals. The goal is to find a reliabl…

This study looks at how menopause changes the way the body processes escitalopram, a common antidepressant. Researchers will measure drug levels in the blood of 94 women aged 40-60 who are premenopausal or menopausal and taking the medication for depression or anxiety. The goal i…

This study tests whether analyzing a person's voice can help predict upcoming depressive or manic episodes in bipolar disorder. Researchers will collect voice recordings and lifestyle data from 170 adults with bipolar disorder over 6 months. The goal is to build a model that spot…

This study explores whether data from your smartphone can warn doctors when depression symptoms are about to return. Researchers will collect phone data from 320 adults who have been treated for depression and are currently well. They will compare this data with monthly mood ques…

This study tests whether short online videos can reduce stigma about depression and improve help-seeking attitudes in teens aged 8-18. About 500 participants, both depressed and non-depressed, will watch either a stigma-reduction video or a neutral video. The goal is to see if th…

This study checks if an AI software can accurately measure depression and anxiety symptoms in 650 adults. Participants will have their symptoms rated by both the AI and human experts to see if the AI works well across different groups. The study does not provide any treatment—it …

This study will test whether training nurses and midwives in respectful maternity care and using a structured action plan can improve outcomes for mothers and newborns after birth. Researchers will compare women who receive standard care with those who receive care after the trai…

This study will test a digital tool called AI-COA® to see how well it measures the severity of depression and anxiety compared to standard clinician ratings. About 150 adults in the U.S. who are starting a new treatment for depression or anxiety will use the tool over 12 weeks. T…

This study will ask 380 heart patients and healthcare workers at Assiut University Heart Hospital to fill out questionnaires about depression, anxiety, stress, and burnout. No treatments or changes are given—the goal is simply to find out how common these mental health problems a…

This pilot study tests a 3-5 minute recorded message called PEACE, designed to improve mental wellbeing and public attitudes toward reintegrating former Boko Haram members in Nigeria. Researchers will enroll 74 adults to see if the intervention is acceptable and feasible. The goa…

This study will give 40 adults with major depression and moderate-to-severe anxiety a single dose of CYB003 (a synthetic version of psilocin, the active ingredient in magic mushrooms) or a placebo. Researchers will use brain scans (fMRI, EEG) and questionnaires to see how the dru…

This study will follow 2,000 adults with major depressive disorder or bipolar disorder to understand why some people get better with treatment and others do not. Researchers will collect information on symptoms, thinking abilities, genetics, metabolism, proteins, and immune marke…

This study looks at whether low magnesium levels are linked to sleep problems in people with major depressive disorder. Researchers will measure magnesium in the blood of 90 adults and compare it to their sleep quality. The goal is to better understand this possible connection, n…

This study will survey about 289 medical students and interns at Assiut University to find out how common anxiety and depression are among them. Researchers will use standard questionnaires to measure symptoms and look for links to academic performance and other risk factors. The…

This study aims to better understand why young people (ages 18-25) with mood disorders may be at risk for suicide. Researchers will collect clinical, brain imaging, genetic, and microbiome data from 180 participants to identify risk factors. They will also test whether a non-inva…

This study will follow 12 people with severe OCD or bipolar disorder who are already scheduled to receive deep brain stimulation (DBS). Researchers will use the DBS device to record brain activity while participants wear smart rings, watches, and phones to track sleep, activity, …

This study will create a large biobank of blood samples and detailed health information from 1,000 people with bipolar disorder in Turkey. Researchers will collect DNA and clinical data to better understand the condition and find genetic clues that could improve diagnosis and tre…