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Brain implant zaps depression without wires

NCT ID NCT07684794

Not yet recruiting Disease control Sponsor: Motif Neurotech, Inc. Source: ClinicalTrials.gov ↗

First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time

Summary

This study tests a small, programmable device implanted in the skull that stimulates the brain's left frontal area to treat depression that hasn't improved with multiple medications. Ten adults with major depressive disorder will receive the implant and be monitored for safety and mood changes. The goal is to see if this approach is safe and could help relieve symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Motif XCS System (implanted brain stimulator)
What this could lead to
If successful, this could offer a new, on-demand brain stimulation option for people with depression that hasn't responded to multiple medications.
What could go wrong
This is a very early, small safety study with only 10 participants. The device requires surgery to implant electrodes in the skull, which carries risks like infection or side effects from stimulation. It may not improve depression.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression Depressive Disorder, Treatment-Resistant major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER (MDD)

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

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