Can therapy reshape the depressed brain? new study aims to find out
NCT ID NCT07091643
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study will use brain scans to see how cognitive behavioural therapy (CBT) affects the brains of 30 people aged 40-60 with major depression. Participants will receive 12 weeks of CBT, with follow-ups up to 9 months. The goal is to understand how CBT improves mood and thinking, and whether brain changes can be seen on MRI.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Cognitive Behavioural Therapy (CBT)
What this could lead to
If successful, this could reveal how CBT changes the brain in midlife depression, pointing toward better treatments that target both mood and cognitive decline.
What could go wrong
This is a small, early-stage study (30 people) focused on brain imaging, not a treatment trial. Results may not apply to everyone, and the therapy may not work for all participants.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Baycrest Hospital
Toronto, Ontario, M6A 2E1, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••