Could a single dose of esketamine calm severe depression during breast cancer surgery?
NCT ID NCT07374211
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a single low dose of esketamine, given during anesthesia for breast cancer surgery, can reduce severe depression and anxiety symptoms right after the operation. Researchers will enroll 242 women with severe depression who are scheduled for breast cancer removal. The goal is to see if this quick intervention improves mood and sleep without major side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
esketamine
What this could lead to
If it works, this could point toward a simple way to reduce severe depression and anxiety during breast cancer surgery recovery.
What could go wrong
This is an early-stage trial with only 242 participants, so results may not apply to everyone. Esketamine can cause side effects like dizziness or nausea.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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