Chinese Pla General Hospital

This study looks at how well ultrasound-guided thermal ablation (using heat to shrink nodules) works for people with benign (non-cancerous) thyroid nodules. Researchers will also create an artificial intelligence model to predict treatment success. About 1500 adults who have symp…

This study compares a new treatment (venetoclax plus the CACAG regimen) to the standard chemotherapy ("3+7") for adults aged 14-75 with newly diagnosed intermediate- or high-risk acute myeloid leukemia (AML). The goal is to see if the new combination leads to more complete remiss…

This study tests a new type of CAR-T cell therapy for adults with B-cell acute lymphoblastic leukemia that has come back or not responded to treatment. The therapy uses donor immune cells that are modified to better target and kill cancer cells while reducing side effects like gr…

This early-phase study tests whether specially designed immune cells (EBV-TCR-T cells) can safely control Epstein-Barr virus (EBV) infections in people who have had a stem cell transplant for blood cancer. About 12 participants aged 14 to 75 will receive the cells and be monitore…

This study compares a new treatment (venetoclax plus CACAG chemo) to the standard 3+7 chemo for people with acute monocytic leukemia. About 204 patients aged 14-60 will take part. The goal is to see if the new combo leads to more complete remissions after one cycle of treatment.

This study tests whether giving fluids tailored to each patient's needs, guided by a lung water monitor, can prevent acute kidney injury in elderly people with mild-to-moderate kidney disease who undergo a heart procedure called coronary angiography. About 320 participants aged 6…

This study compares two drug combinations for people whose acute myeloid leukemia (AML) has returned or not responded to treatment. About 200 participants aged 14 to 75 will receive either venetoclax plus CACAG or the standard BAT regimen. The goal is to see which combo leads to …

This study compares a minimally invasive heat-based treatment (thermal ablation) with standard surgery for people with small, low-risk papillary thyroid cancer. About 3,700 adults aged 18–80 with tumors 2 cm or smaller will be followed for at least a year. Researchers will also d…

This study tests whether using heat (thermal ablation) to destroy overactive thyroid tissue, along with standard antithyroid drugs, can better control hyperthyroidism. About 454 people with primary hyperthyroidism will receive this combined treatment. The goal is to see if it hel…

This study tests a new treatment called QH101 for people with blood cancers or solid tumors that have not responded to standard therapies. QH101 uses specially engineered immune cells from a donor to better recognize and kill cancer cells while lasting longer in the body. The tri…

This study tests a new treatment called RAK cell therapy for people with advanced stomach cancer that has spread or come back after standard treatments. The therapy uses immune cells from donated umbilical cord blood to help fight the cancer. The goal is to see if it can help pat…

This study tests a new type of metal plate designed to fix fresh fractures of the femoral neck (the part of the hip bone just below the ball joint). The goal is to see if this plate helps the bone heal better and with fewer problems than current methods. About 1150 adults who nee…

This study tests a new drug called pegmolesatide for anemia in people with chronic kidney disease who are on dialysis. About 240 adults will be split into three groups to compare different doses of pegmolesatide against their current treatment. The goal is to see if the new drug …

This study tests a new first-line treatment for people with advanced colorectal cancer that cannot be removed by surgery or has spread. The treatment combines two drugs, levozolinate and 5-FU, given together through an IV. The goal is to see if this approach helps control the can…

This study tests whether adding two drugs (ruxolitinib and decitabine) to the standard chemotherapy given before a stem cell transplant can lower the chance of leukemia returning in high-risk patients. About 200 adults and teens with acute myeloid leukemia in first remission will…

This study tests a new treatment called anti-BCMA-CD19 CAR-T cells for adults with IgG4-related disease that hasn't improved with standard therapies. Participants will have their immune cells collected, receive a short course of chemotherapy, and then get an infusion of the modif…

This study tests whether adding a GSL synthetase inhibitor (eliglustat) to standard treatments can shrink tumors or slow cancer growth in people with advanced colorectal cancer that has not responded to at least two prior therapies. About 120 adults with a specific tumor type (pM…

This study tests a new combination of drugs (venetoclax, azacitidine, chidamide, and others) against the standard chemotherapy for adults aged 60-75 with newly diagnosed acute myeloid leukemia (AML). The goal is to see if the new combo leads to more complete remissions and fewer …

This study tests whether adding eculizumab to standard steroid therapy helps people with neuromyelitis optica spectrum disorder (NMOSD) recover better from sudden attacks. It involves 200 adults with a specific antibody (AQP4-positive) who are in the early phase of an attack. The…

This study tests whether adding the immunotherapy drug camrelizumab to standard chemoradiotherapy can help shrink tumors completely in people with locally advanced rectal cancer. About 44 adults aged 18-75 with a specific type of rectal cancer (pMMR/MSS) will receive a sequence o…

This study tests whether adding the drug eliglustat to standard CD30-targeted immunotherapy can improve outcomes for people with CD30-positive lymphoma. About 40 adults who have already tried at least one other treatment will receive either a CAR-T cell therapy or an antibody-dru…

This study tests whether adding two drugs, ruxolitinib and chidamide, to the standard chemo given before a stem cell transplant can lower the chance of leukemia coming back. It includes 50 people aged 12 to 65 with high-risk B-cell acute lymphoblastic leukemia who have a suitable…

This study tests a new combination of drugs (Chidamide, Decitabine, and an anti-PD-1 antibody) for people with relapsed or treatment-resistant classical Hodgkin lymphoma who are not eligible for or refuse a stem cell transplant. The goal is to see if this combination helps keep t…

This study tests a new treatment called Amimestrocel, made from stem cells, for people with acute kidney injury (sudden kidney damage). Researchers want to see if it can safely improve kidney function and reduce the need for dialysis. About 50 adults aged 18 to 75 will take part.…

This study is testing whether an injection of stem cells from umbilical cords can help people with progressive diabetic kidney disease. Researchers want to see if the treatment, called Amimestrocel, can improve kidney function and reduce protein in the urine. The trial will enrol…

This study is testing a new wearable ultrasound sensor that sticks to the skin to help doctors find and monitor diseases like deep vein thrombosis (DVT) and heart conditions early. About 300 adults with DVT, heart failure, or those in the ICU will wear the sensor to see how clear…

This study looks at whether a special exercise program (pulmonary rehabilitation) can help people who need high flow oxygen therapy. About 70 adults with stable vital signs will take part. The goal is to see if the program improves breathing, muscle strength, and daily living act…

This study tests a new way to treat an enlarged prostate (BPH) using steam delivered precisely with MRI guidance. It aims to ease urinary symptoms like frequent or weak urination. About 30 men aged 45-85 with moderate to severe symptoms will get the treatment and be followed for …

This study tests whether giving a low dose of midazolam (a sedative) during surgery can lower the risk of confusion (delirium) and anxiety in older adults after their operation. About 612 patients aged 65-85 having non-heart, non-brain surgery will be randomly assigned to receive…

This study looks at whether a special breathing therapy called OLE (Oscillatory Lung Expansion) helps ICU patients with pneumonia clear mucus from their lungs. Researchers will use a lung imaging tool (EIT) to see how well the therapy works. About 62 adults in the ICU who have a …

This study is a large survey of over 12,500 Chinese men aged 40 and older. Researchers will use questionnaires and tests to measure how common lower urinary tract symptoms are and how they affect quality of life. The goal is to understand the problem better and improve future car…