Chinese Pla General Hospital

This study tests whether adding eculizumab to standard steroid therapy helps people with neuromyelitis optica spectrum disorder (NMOSD) recover better from sudden attacks. About 200 adults with a specific antibody (AQP4-positive) will be followed in real-world clinics. The goal i…

This study tests whether adding a GSL synthetase inhibitor (eliglustat) to standard immunotherapy and/or regorafenib can shrink tumors or slow disease in people with advanced colorectal cancer that has not responded to at least two prior treatments. About 120 adults with a specif…

This study tests a new treatment called Amimestrocel, made from stem cells, for people with acute kidney injury (sudden kidney damage). The goal is to see if it can safely help kidneys recover and reduce the need for dialysis. About 50 adults aged 18 to 75 will receive the treatm…

This study tests whether adding the immunotherapy drug camrelizumab to standard chemoradiation can make rectal cancer disappear completely in more patients. About 44 adults with locally advanced rectal cancer will receive the combination before any surgery. The goal is to increas…

This study tests whether a new combination of drugs (venetoclax plus CACAG) works better than another standard combination (BAT) for people whose acute myeloid leukemia has come back or not responded to treatment. About 200 participants aged 14 to 75 will be randomly assigned to …

This early study tests a new treatment using specially trained immune cells (EBV-TCR-T cells) to fight Epstein-Barr virus (EBV) infections that can occur after a stem cell transplant. About 12 people aged 14 to 75 who have had a stem cell transplant for blood cancer and now have …

This study tests two drug combinations for people with classical Hodgkin lymphoma that has come back or not responded to treatment, and who cannot or choose not to have a stem cell transplant. About 100 adults aged 18-75 will be randomly assigned to receive either a combination o…

This study tests a new first-line treatment for people with advanced colorectal cancer that cannot be removed by surgery or has spread. The treatment combines two drugs, levozolinate and 5-FU, given together through an IV. The goal is to see if this approach helps control the can…

This study tests whether adding two drugs (ruxolitinib and decitabine) to standard chemotherapy before a stem cell transplant can lower the chance of acute myeloid leukemia returning in high-risk patients who are in first remission. About 200 participants aged 12–64 will be rando…

This study tests a new combination of drugs (venetoclax, azacitidine, chidamide, and others) against the standard chemotherapy for adults aged 60-75 with newly diagnosed acute myeloid leukemia (AML). The goal is to see if the new combo leads to higher remission rates and fewer si…

This study compares a new treatment (venetoclax plus CACAG) to standard chemotherapy for people with acute monocytic leukemia. About 204 participants aged 14-60 will be randomly assigned to one of the two groups. The goal is to see if the new combination leads to more complete re…

This study looks at how well ultrasound-guided thermal ablation (using heat to shrink nodules) works for people with benign (non-cancerous) thyroid nodules. Researchers will also create an artificial intelligence model to predict treatment success. About 1500 adults who have symp…

This study compares a new treatment (venetoclax plus the CACAG regimen) to the standard chemotherapy ("3+7") for adults aged 14-75 with newly diagnosed intermediate- or high-risk acute myeloid leukemia (AML). The goal is to see if the new combination leads to more complete remiss…

This study tests a new type of CAR-T cell therapy for adults with B-cell acute lymphoblastic leukemia that has come back or not responded to treatment. The therapy uses donor immune cells that are modified to better target and kill cancer cells while reducing side effects like gr…

This study tests a new treatment called RAK cell therapy for people with advanced stomach cancer that has spread or come back after standard treatment. The therapy uses immune cells from donated umbilical cord blood to fight the cancer. About 90 adults will be randomly assigned t…

This study tests whether giving fluids tailored to each patient's needs, guided by a lung water monitor, can prevent acute kidney injury in elderly people with mild-to-moderate kidney disease who undergo a heart procedure called coronary angiography. About 320 participants aged 6…

This study compares a minimally invasive heat-based treatment (thermal ablation) with standard surgery for people with small, low-risk papillary thyroid cancer. About 3,700 adults aged 18–80 with tumors 2 cm or smaller will be followed for at least a year. Researchers will also d…

This study tests whether using heat (thermal ablation) to destroy overactive thyroid tissue, along with standard antithyroid drugs, can better control hyperthyroidism. About 454 people with primary hyperthyroidism will receive this combined treatment. The goal is to see if it hel…

This study tests a new treatment called QH101 for people with blood cancers or solid tumors that have not responded to standard therapies. QH101 uses specially engineered immune cells from a donor to better recognize and kill cancer cells while lasting longer in the body. The tri…

This study tests a new type of metal plate designed to fix fresh fractures of the femoral neck (the part of the hip bone just below the ball joint). The goal is to see if this plate helps the bone heal better and with fewer problems than current methods. About 1150 adults who nee…

This study tests a new drug called pegmolesatide for anemia in people with chronic kidney disease who are on dialysis. About 240 adults will be split into three groups to compare different doses of pegmolesatide against their current treatment. The goal is to see if the new drug …

This study tests a new treatment called anti-BCMA-CD19 CAR-T cells for adults with IgG4-related disease that hasn't improved with standard therapies. Participants will have their immune cells collected, receive a short course of chemotherapy, and then get an infusion of the modif…

This study tests whether adding the drug eliglustat to standard CD30-targeted immunotherapy can improve outcomes for people with CD30-positive lymphoma. About 40 adults who have already tried at least one other treatment will receive either a CAR-T cell therapy or an antibody-dru…

This study tests whether adding two drugs, ruxolitinib and chidamide, to the standard chemo given before a stem cell transplant can lower the chance of leukemia coming back. It includes 50 people aged 12 to 65 with high-risk B-cell acute lymphoblastic leukemia who have a suitable…

This study is testing whether an injection of stem cells from umbilical cords can help people with progressive diabetic kidney disease. Researchers want to see if the treatment, called Amimestrocel, can improve kidney function and reduce protein in the urine. The trial will enrol…

This study is testing a new wearable ultrasound sensor that sticks to the skin to help doctors diagnose and monitor conditions like deep vein thrombosis (DVT) and heart failure in real time. About 300 adults with these conditions or those in the ICU will wear the sensor to see ho…

This study looks at whether a special exercise program (pulmonary rehabilitation) can help people who need high flow oxygen therapy. Researchers will measure muscle strength, breathing, and daily living skills in 70 adults. The goal is to see if rehab can make it easier for patie…

This study tests a laser surgery for men with an enlarged prostate but a small gland size. The goal is to see if adding a bladder neck cut to the standard laser procedure reduces complications like scarring and improves urination. About 426 men aged 40-80 will be randomly assigne…

This study tests a new way to treat an enlarged prostate (BPH) using steam delivered precisely with MRI guidance. It aims to ease urinary symptoms like frequent or weak urination. About 30 men aged 45-85 with moderate to severe symptoms will get the treatment and be followed for …

This study looks at whether giving a small amount of the sedative midazolam during surgery can help prevent confusion (delirium) and anxiety in older adults after their operation. About 612 patients aged 65 to 85 having non-heart, non-brain surgery will be randomly assigned to re…

This study looks at whether a therapy called OLE (Oscillatory Lung Expansion) helps ICU patients with pneumonia clear mucus from their lungs. Researchers will use a special imaging technique (EIT) to see how the lungs respond. About 62 adults in the ICU will take part, and the ma…

This study is a large survey of over 12,500 men aged 40 and older across China. Its goal is to measure how common lower urinary tract symptoms are and how they affect quality of life. Researchers will use questionnaires and tests to gather information, aiming to improve public he…