Chinese Pla General Hospital

This study tests whether a mixture of viruses called bacteriophages can safely and effectively treat ventilator-associated pneumonia caused by drug-resistant bacteria. About 248 adults on ventilators with confirmed infections will receive the phage cocktail. The goal is to improv…

This early-phase trial tests whether combining a traditional Chinese herbal formula (Yiqi Huoxue Jiedu) with bacteriophages (viruses that kill bacteria) can clear drug-resistant bacteria from the lungs of 240 adults with severe pneumonia. The goal is to improve recovery and lower…

This study tests whether adjusting the dose of the antifungal drug isavuconazole based on individual patient factors can improve treatment for elderly patients with invasive fungal infections. Researchers will measure drug levels in the blood and compare standard dosing to person…

This study tests a new treatment plan for people with a certain type of advanced rectal cancer. The plan combines a short course of radiation with chemotherapy, targeted drugs, and immunotherapy before any surgery. The goal is to see if this approach can make the tumor disappear …

This study tests a combination of two drugs (tunlametinib and an anti-EGFR antibody) in people with advanced colorectal or pancreatic cancer that has a RAS gene mutation and has not responded to standard treatments. The goal is to see if the combo can shrink tumors or slow cancer…

This early study tests a new way to treat drug-resistant epilepsy using focused ultrasound waves guided by MRI. The waves create a small burn in a brain area linked to seizures, aiming to reduce seizure frequency. Twenty adults who have not responded to at least two medications w…

This early-phase study tests a combination of a specially designed virus (PIN) and an immunotherapy drug (sintilimab) in up to 25 adults with advanced colorectal cancer that has spread to the liver and hasn't responded to at least two prior treatments. The goal is to see if this …

This study tests a special ultrasound to see if it can find tiny metal pieces left in the brain after aneurysm surgery. About 78 adults who had brain surgery will get this ultrasound within 3 hours after their operation. The goal is to see if this new method can spot metal fragme…

This study tests a new device called Medstrom that monitors pain, sedation, and muscle relaxation all in one during laparoscopic colon cancer surgery. It aims to replace multiple separate monitors, reduce delays, and lower costs. About 30 adults having elective surgery will be ra…

This study tests if spraying a local anesthetic inside the chest can ease pain caused by drainage tubes after lung surgery. About 300 adults having lung surgery will be randomly assigned to receive one of two numbing sprays or a placebo spray. Researchers will measure pain levels…

This study looks at whether giving esketamine continuously during breast cancer surgery can help reduce anxiety and depression in patients who already have mild-to-severe depression. About 142 women will take part, and their mood and sleep quality will be tracked before and after…

This study tests an experimental drug called NB001 for quickly stopping migraine pain and bothersome symptoms in adults. About 120 people with migraines will receive either NB001 or a placebo pill. The main goal is to see if more people are pain-free and symptom-free two hours af…

This study tests a simple, non-invasive ear stimulation (taVNS) given during breast cancer surgery to see if it can lower anxiety, depression, pain, and nausea after the operation. About 232 adults having breast cancer surgery will be randomly assigned to receive either real or s…

This study looks at how well acemetacin, a nonsteroidal anti-inflammatory drug (NSAID), works for adults with active axial spondyloarthritis—a type of arthritis that mainly affects the spine. About 150 people aged 18 to 65 will take a daily 90 mg pill for 4 weeks. Researchers wil…

This study tests whether giving esketamine during breast cancer surgery can reduce severe depression and anxiety in 242 women. Participants have severe depressive symptoms before surgery and will receive either esketamine or a placebo during their operation. The goal is to see if…

This study tests whether a mild electrical pulse to a nerve in the ear during heart surgery can lower the chance of confusion (delirium) and reduce anxiety and depression after the operation. About 270 adults having planned heart surgery will receive either the real stimulation o…

This study tests a simple device that measures the carbon dioxide you breathe out during painless stomach and colon exams. It gives doctors an early warning if your breathing slows down, helping prevent dangerously low oxygen levels. The study will include 460 adults getting both…

This study tests whether giving esketamine continuously during breast cancer surgery can reduce feelings of anxiety and depression after the operation. About 218 adults having breast cancer removal will be randomly assigned to receive esketamine or a placebo during anesthesia. Re…

This study will test a new type of CT scanner (photon counting CT) to see if it can give clearer pictures of fatty or calcified plaques in heart arteries. Researchers want to know if these detailed images can help predict who might have a heart attack, stroke, or need a procedure…

This observational study will follow 100,000 elderly Chinese adults to see how conditions like diabetes, high blood pressure, and high cholesterol impact the development and progression of chronic kidney disease (CKD). Participants will provide health data through clinic visits a…

This study looks at whether measuring sugar use in a key memory part of the brain can help predict confusion (delirium) after surgery in older adults with type 2 diabetes. Researchers will scan the brains of 154 people before liver surgery and check for confusion afterward. The g…

This study will follow 10,000 adults with obesity across 50 hospitals in China to see what treatments doctors actually use and how patients respond. Participants will get routine weight-loss care, and researchers will collect health data like weight, blood tests, and liver scans …

This study looks at how to give the antibiotic ceftobiprole more safely and effectively to people aged 60 and older. Researchers will measure drug levels in the blood and use computer models to adjust each person's dose. The goal is to find the right dose for each patient to impr…

This study will follow 500 Beijing residents aged 60 and older to see how urinary function (like bladder and kidney health) is linked to multiple chronic conditions such as high blood pressure, diabetes, and heart disease. Participants will have regular health check-ups, blood an…

This study aims to find the best dose of the antibiotic ceftazidime-avibactam for people aged 60 and older. Researchers will measure drug levels in the blood and use computer models to adjust each person's dose. The goal is to make treatment more effective and reduce the risk of …