Could a new oral ketamine capsule ease bipolar depression when other treatments fail?
NCT ID NCT07644767
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests an oral ketamine capsule (KET-AD) designed to be abuse-deterrent in adults with treatment-resistant bipolar depression. About 160 participants will receive either KET-AD or a placebo, taken three times a week for up to 7 weeks, alongside their usual treatment. The goal is to see if it safely improves depressive symptoms.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
KET-AD (oral ketamine capsule)
What this could lead to
If successful, this could offer a new, abuse-deterrent oral option for people with bipolar depression who haven't responded to standard treatments.
What could go wrong
This is an early phase 2 trial with a small sample size, so results may not confirm effectiveness. Ketamine can cause side effects like dissociation or nausea, and the abuse-deterrent design is still being tested.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.