Brain scans reveal how ketamine works in stubborn bipolar depression

NCT ID NCT06620042

Completed Knowledge-focused Sponsor: Brian Barnett Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at how ketamine affects brain connections in people with bipolar depression that hasn't improved with other treatments. Twenty adults received ketamine and had brain scans before and after. The goal was to see if changes in brain activity could predict who gets better.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ketamine
What this could lead to: If successful, this could help identify brain changes that predict who will respond to ketamine, potentially guiding more personalized treatment for bipolar depression.
What could go wrong: This is a small, early-phase study with only 20 participants and no placebo group. The results may not apply to everyone, and the brain scan findings may not lead to clear clinical benefits.

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Conditions

The condition(s) this trial relates to.

bipolar depression bipolar disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BIPOLAR DEPRESSION TREATMENT RESISTANT BIPOLAR DEPRESSION

Contacts and locations

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Locations

Cleveland Clinic Lutheran Hospital

Cleveland, Ohio, 44113, United States
Cleveland Clinic Lutheran Hospital

Ohio City, Ohio, 44113, United States

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