New therapy aims to lift depression in HIV-Positive teens
NCT ID NCT07211087
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests an enhanced version of depression treatment (COMBEX) for youth aged 15-24 with HIV. It combines therapy, medication management, and extra support strategies to improve mood and HIV care. Researchers will compare it to standard combination therapy over 72 weeks in 130 participants.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
behavioral therapy (cognitive behavioral therapy and medication management)
What this could lead to
If successful, this could provide a more effective, sustainable way to treat depression in youth with HIV, improving both mental health and HIV outcomes.
What could go wrong
This is an early-stage behavioral trial with 130 participants, so results may not apply broadly. The enhanced therapy may not significantly outperform the standard approach.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••