Head-to-Head: which drug tames mania best?
NCT ID NCT07665073
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two approved antipsychotic drugs, risperidone and cariprazine, in 50 adults with bipolar 1 disorder experiencing acute mania. Participants take one of the drugs for 6 weeks, and doctors measure how well symptoms improve using a standard mania rating scale. The goal is to see which drug works better and has fewer side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Risperidone and Cariprazine (antipsychotic drugs)
- What this could lead to
- If this trial shows one drug works better or has fewer side effects, it could help doctors choose the best treatment for manic episodes in bipolar disorder.
- What could go wrong
- This is a small, early-stage comparison with only 50 people. Results may not apply to everyone, and both drugs already have known side effects like drowsiness or weight gain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for BIPOLAR 1 DISORDER are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a Two-Drug combo help teens with severe mental illness?
- Childhood Trauma's lasting mark on bipolar brains under the microscope
- Can brain scans and eye movements predict psychosis recovery?
- Brain biotype may predict best antipsychotic drug
- Can a simple blood test unlock secrets of Alzheimer's and depression?
- Your income and social life may predict brain health, study finds