Brain biotype may predict best antipsychotic drug

NCT ID NCT04580134

Recruiting now Disease control Sponsor: University of Texas Southwestern Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares clozapine and risperidone in people with schizophrenia, schizoaffective disorder, or bipolar I disorder with psychosis. Researchers want to see if a specific brain biotype (Biotype-1) responds better to clozapine. About 320 participants will be randomly assigned to one of the two drugs for 18 weeks, and symptom changes will be measured.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: clozapine and risperidone
What this could lead to: If successful, this could show that matching treatment to a person's biotype improves outcomes for psychosis.
What could go wrong: This is a mid-stage trial; results may not apply to everyone, and clozapine has known risks like low white blood cell counts that require monitoring.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bipolar I disorder Psychotic Disorders schizoaffective disorder schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BIPOLAR 1 DISORDER SCHIZOAFFECTIVE DISORDER SCHIZOPHRENIA

Contacts and locations

Locations

Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02115, United States
Hartford Healthcare
RECRUITING

Hartford, Connecticut, 06106, United States
UT Southwestern Medical Center
RECRUITING

Dallas, Texas, 75235, United States
University of Chicago
RECRUITING

Chicago, Illinois, 60615, United States
University of Georgia
RECRUITING

Athens, Georgia, 30602, United States

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