Could a common gout pill boost antidepressants?
NCT ID NCT07574060
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether adding allopurinol, a drug usually used for gout, to the antidepressant sertraline can better relieve symptoms of major depressive disorder. Researchers will enroll 70 adults with moderate to severe depression and measure changes in their depression scores over time. The goal is to see if this combination works better than sertraline alone.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Allopurinol (a gout medication) added to sertraline (an antidepressant)
What this could lead to
If it works, this could point toward a new, low-cost add-on treatment for depression that helps people who don't respond to antidepressants alone.
What could go wrong
This is an early-stage trial with only 70 participants, so results may not apply to everyone. Allopurinol is not a standard depression treatment, and its benefit is uncertain.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for DEPRESSION are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Tanta Unuversity
Tanta, 31527, Egypt