Could a common gout pill boost antidepressants?

NCT ID NCT07574060

Not yet recruiting Symptom relief Sponsor: Tanta University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding allopurinol, a drug usually used for gout, to the antidepressant sertraline can better relieve symptoms of major depressive disorder. Researchers will enroll 70 adults with moderate to severe depression and measure changes in their depression scores over time. The goal is to see if this combination works better than sertraline alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Allopurinol (a gout medication) added to sertraline (an antidepressant)
What this could lead to: If it works, this could point toward a new, low-cost add-on treatment for depression that helps people who don't respond to antidepressants alone.
What could go wrong: This is an early-stage trial with only 70 participants, so results may not apply to everyone. Allopurinol is not a standard depression treatment, and its benefit is uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION

Contacts and locations

Locations

Tanta Unuversity

Tanta, 31527, Egypt

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