Gut-Brain hope: probiotic trial targets depression

NCT ID NCT07667530

Not yet recruiting Symptom relief Sponsor: University of Reading Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether taking a probiotic supplement called Ecologic® Barrier for 16 weeks can reduce depressive symptoms and change brain activity in adults aged 25-40 with mild-to-moderate depression. Participants will be randomly assigned to receive the probiotic or a placebo. The goal is to see if this supplement offers a safe, non-drug way to ease depression.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Probiotic supplement (Ecologic® Barrier)
What this could lead to: If it works, this could point toward a simple, non-drug option to help manage mild-to-moderate depression.
What could go wrong: This is an early-stage study with only 76 people, so results may not apply widely. The supplement may have no effect on mood or brain activity.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

depressive disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EXECUTIVE FUNCTION (COGNITION) MILD TO MODERATE DEPRESSION NEURAL ACTIVITY

Contacts and locations

Locations

School of Psychology and Clinical Languages

London, RG6 6UR, United Kingdom

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