Can social rhythm therapy replace meds for bipolar II?
NCT ID NCT07654348
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial compares the drug quetiapine with interpersonal and social rhythm therapy (IPSRT) in 216 people with bipolar II disorder who have disrupted daily rhythms. Participants will be randomly assigned to one of the two treatments for 12 weeks. Researchers will measure changes in depression severity, biological rhythms, and explore how IPSRT might work by looking at stress hormones and brain activity.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- quetiapine
- What this could lead to
- If successful, this could show that social rhythm therapy is a safe, effective alternative or addition to medication for managing bipolar II depression.
- What could go wrong
- This is an early phase 2 trial with only 216 participants, so results may not apply broadly. Quetiapine has known side effects, and the therapy requires weekly sessions for 12 weeks.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
The First Affiliated Hospital of Zhejiang University
Hangzhou, Zhejiang, 310000, China
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Other studies related to the condition(s) this trial covers.