First Affiliated Hospital Of Zhejiang University

This study tests two drugs, trastuzumab rezetecan and toripalimab, given before surgery to women with HR-positive, HER2-low breast cancer. The goal is to see if this combination can completely eliminate the cancer by the time of surgery. About 111 women aged 18-70 with early-stag…

This phase 3 trial compares two conditioning regimens before stem cell transplant in adults over 50 with acute myeloid leukemia or myelodysplastic syndrome. One group gets standard chemotherapy (fludarabine + melphalan), the other adds venetoclax, a targeted pill. The goal is to …

This study tests a combination of three drugs (mitoxantrone liposome, cytarabine, and venetoclax) in 72 adults with acute myeloid leukemia that has returned or not responded to prior therapy. The goal is to see if this combo can achieve complete remission. Participants will recei…

This study looks at whether using two types of blood thinners (anticoagulant plus antiplatelet) after a vein stent procedure helps keep the vein open longer and prevents blood clots from returning. About 172 people with deep vein thrombosis and a narrowed iliac vein will take par…

This study tests a new treatment approach for people with rectal cancer that has spread to a limited number of other organs (called oligometastases). The treatment combines short-course radiation, chemotherapy, and an immunotherapy drug called serplulimab. The goal is to see if t…

This study tests whether adding etanercept to the standard drug ruxolitinib works better for severe graft-versus-host disease (GVHD) that doesn't respond to steroids. GVHD is a life-threatening complication after a stem cell transplant where donor cells attack the patient's body.…

This study will follow 400 people with early Alzheimer's disease who are taking lecanemab, a drug that removes amyloid plaques from the brain. Researchers want to see if simple blood tests can track the drug's effects as accurately as brain scans. The goal is to make monitoring e…

This early-phase study tests a new treatment called A-CAR028 for people with acute myeloid leukemia (AML) that has come back or not responded to standard therapy. The treatment uses specially engineered immune cells (CAR-T cells) to attack the cancer. The main goals are to check …

This study tests whether etamsylate, a drug that helps blood clot, can prevent serious bleeding in people with very low platelet counts after a stem cell transplant. About 404 adults will receive either etamsylate or a placebo, and researchers will track who has a major bleed or …

This study tests a new drug, orelabrutinib, combined with chemotherapy for people newly diagnosed with marginal zone lymphoma, a rare blood cancer. About 69 participants will receive the treatment to see if it improves tumor shrinkage and helps control the disease long-term. The …

This study tests a new treatment for people with locally advanced rectal cancer that has not spread. The treatment combines short-course radiation with chemotherapy and two immunotherapy drugs (iparomlimab and tuvonralimab). The goal is to shrink the tumor enough to avoid surgery…

This study tests a new drug called gecacitinib (jaktinib) combined with steroids as a first treatment for people with moderate to severe graft-versus-host disease (GVHD) after a stem cell transplant. About 35 adults who have recently received a transplant and started steroids wit…

This study tests a new treatment plan for people aged 60 and older who have been newly diagnosed with acute myeloid leukemia (AML) and cannot have strong chemotherapy. The treatment uses two different drug combinations given one after the other. The goal is to see if this approac…

This study tests whether adding venetoclax to the standard chemotherapy before a stem cell transplant can help prevent cancer from returning in people with high-risk acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). About 138 participants aged 12 to 60 will be rand…

This study tests whether adding two targeted drugs (sintilimab and bevacizumab) to standard chemotherapy before surgery can completely eliminate triple-negative breast cancer in 37 women with stage II-III disease. The main goal is to see how many patients have no cancer left in t…

This study tests a new treatment for adults with a specific type of acute myeloid leukemia (FLT3-ITD). The goal is to see if a combination of drugs (gilteritinib, venetoclax, and azacitidine) followed by high-dose chemotherapy can control the disease well enough to avoid a stem c…

This study tests whether adding the immunotherapy drug toripalimab to standard chemotherapy before surgery can completely eliminate triple-negative breast cancer in 35 women. Participants will receive the drug combination, then have surgery, and be followed for side effects and c…

This study tests a drug called romiplostim N01 to see if it can help platelets recover faster after a stem cell transplant in people with blood cancers like leukemia. About 130 participants will either get the drug or standard care. The goal is to reduce bleeding risk and improve…

This study tests if a special stent can safely block blood flow to brain aneurysms (weak spots in blood vessels). About 164 people aged 18-80 with certain types of aneurysms will receive the stent. The main goal is to see if the aneurysm is fully sealed one year after the procedu…

This study is testing a new type of MRI scan to see if it can find prostate cancer more accurately than current methods. About 2000 men with suspected prostate cancer will get this special MRI, and the results will be checked against standard biopsies. The goal is to develop a be…

This study tests whether organized dragon boat training helps breast cancer patients recover better than unsupervised home exercises. 72 women who had breast cancer surgery will be assigned to either a 12-week dragon boat program or home workouts. The goal is to see which approac…

This study compares a newer sedative, remimazolam, to the standard drug propofol for patients at high risk of breathing problems during a painless lung scope (bronchoscopy). The goal is to see if remimazolam lowers the chance of low oxygen levels and helps patients wake up faster…

This study tests a modified oxygen delivery method for people undergoing a lung procedure called bronchoscopy under deep sedation. The method uses a thin, flexible tube placed through the nose to deliver oxygen, aiming to prevent low oxygen levels (hypoxia) during the procedure. …

This observational study looks at very small movements (micro-movements) in people who have been in a coma or minimally conscious state for over a month after a severe brain injury. Researchers want to see if these tiny responses to emotional cues can help assess a patient's leve…

This study compares a new type of laryngeal mask (GMA) with the traditional one used to help patients breathe during general anesthesia. About 1,384 adults having planned surgery will take part to see which mask is safer, more comfortable, and easier for doctors to use. The goal …

This study looks at tiny, involuntary facial expressions (micro-expressions) in 200 people with long-term consciousness disorders. Researchers use emotional stimuli to trigger these expressions and combine them with brain scans (EEG, MRI) to better classify a patient's level of a…

This study looks at whether a special type of PET/MRI scan (18F-FAPI) can accurately diagnose and track myelofibrosis, a serious bone marrow disorder. Researchers will compare the scan results with the standard bone marrow biopsy in 57 participants. The goal is to see if this non…

This study is testing whether an artificial intelligence (AI) model can predict serious bleeding after stomach cancer surgery. Researchers will collect data from 7,000 adults who had their stomach removed due to cancer. The goal is to help doctors decide earlier if a second surge…