First Affiliated Hospital Of Zhejiang University

This study is testing a medical device called a flow-diverting stent to treat brain aneurysms, which are weak, bulging spots in a brain artery. Researchers will implant these tiny mesh tubes in 164 patients to redirect blood flow away from the aneurysm, aiming to seal it off. The…

This study is testing whether a combination of two drugs, trastuzumab rezetecan and toripalimab, can shrink tumors before surgery in people with a specific type of breast cancer (HR-positive, HER2-low). The main goal is to see if the treatment completely eliminates cancer cells i…

This study is testing if adding a drug called venetoclax to the standard pre-transplant chemotherapy improves outcomes for people with high-risk acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). About 138 patients aged 12-60 will be randomly assigned to receive eit…

This study is for people over 50 with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) who are getting a stem cell transplant. It compares two different drug combinations used to prepare the body for the transplant. The goal is to see if adding a drug called venetoc…

This study is testing a new treatment approach for people with a common type of advanced rectal cancer. It combines a short course of radiation, standard chemotherapy, and two new immunotherapy drugs to try to shrink tumors before surgery. The main goal is to see if this combinat…

This study is testing a three-drug combination given before surgery for triple-negative breast cancer (TNBC). The goal is to see if adding two newer drugs (sintilimab and bevacizumab) to standard chemotherapy can more effectively shrink or eliminate the tumor. Researchers will me…

This early-stage study is testing the safety and initial effectiveness of a new CAR-T cell therapy called A-CAR028 for adults with acute myeloid leukemia (AML) that has returned or not responded to other treatments. The study will enroll up to 20 participants to determine safe do…

This study is testing whether a combination of two blood-thinning medications can help keep a vein open after a stent is placed. It's for patients who have had a serious leg blood clot and a narrowed iliac vein that required a stent. Researchers want to see if this drug combinati…

This study is testing if a weekly injection called Romiplostim N01 can help platelets recover faster after a stem cell transplant for blood cancers like leukemia. About 130 patients will be randomly assigned to receive either the new drug or standard care, and researchers will tr…

This study is for patients who develop a severe, life-threatening immune reaction (GVHD) after a stem cell transplant that doesn't respond to standard steroid treatment. It will test if adding a drug called etanercept to the current standard drug, ruxolitinib, works better than r…

This study is testing whether adding an immunotherapy drug called toripalimab to standard chemotherapy before surgery can be more effective for treating triple-negative breast cancer. It will involve about 35 women with early-stage disease to see if this combination can completel…

This study is testing whether adding a newer drug called orelabrutinib to standard treatments works better for people newly diagnosed with marginal zone lymphoma, a type of blood cancer. It has two groups: one for younger, fitter patients and one for older patients or those less …

This study is testing a new drug called gecacitinib, combined with standard steroid treatment, for patients who develop a severe immune reaction called acute graft-versus-host disease after a stem cell transplant. The trial aims to find the safest and most effective dose and see …

This study is testing whether alternating two different drug combinations can better control acute myeloid leukemia (AML) in older adults or those with other health problems who cannot tolerate standard intensive chemotherapy. The treatment involves four cycles of alternating dru…

This study is testing if a drug called etamsylate can prevent serious bleeding in patients who have low platelet counts after a stem cell transplant. About 404 adult patients will be randomly assigned to receive either etamsylate or a placebo (inactive substance) to see which is …

This study is testing a new treatment plan for adults with a specific genetic type of acute myeloid leukemia (AML). The goal is to see if a combination of targeted drugs and chemotherapy can control the cancer so well that a risky stem cell transplant might be avoided. Researcher…

This study is testing whether a new three-drug combination can help control acute myeloid leukemia (AML) that has returned or hasn't responded to previous treatments. The trial will enroll 72 adults with relapsed or refractory AML to receive the drug combination and closely monit…

This study is testing a new combination treatment for people with rectal cancer that has spread to a few other places in the body. The goal is to see if a short course of radiation, followed by chemotherapy and an immunotherapy drug, can better control the cancer and reduce the c…

This study is testing if a new type of imaging scan (called 18F-FAPI PET/MRI) can be used to diagnose and monitor myelofibrosis, a serious bone marrow disease. Researchers want to see if this scan is as good as or better than the current painful bone marrow biopsy, which cannot b…

This study is testing if a new type of MRI scan can better detect prostate cancer. The scan looks at the size and density of cells inside the prostate, which may give doctors a clearer picture than standard MRI. About 2,000 men with suspected prostate cancer will get both the new…

This study compares two exercise programs to help women recover after breast cancer surgery. Researchers want to see if 12 weeks of supervised dragon boat racing with a coach works better than following exercise videos at home alone. They will measure changes in body composition,…

This study is testing whether a new sedative drug called remimazolam can make bronchoscopy procedures safer for high-risk patients. Bronchoscopy involves inserting a camera into the lungs and often requires sedation, but current sedatives can sometimes cause breathing problems. R…

This study is testing a modified oxygen delivery method for patients undergoing sedated lung exams (bronchoscopy). Researchers are using a thinner breathing tube inserted through the nose to see if it provides better oxygen flow and reduces the risk of low oxygen levels during th…

This study aims to see if specific blood tests can accurately track how well the Alzheimer's drug lecanemab is working. Researchers will observe 400 patients in China with early Alzheimer's who are already taking lecanemab. They will collect blood samples and brain scans over 18 …

This study aims to learn more about patients with prolonged disorders of consciousness, such as those in a vegetative or minimally conscious state after a severe brain injury. Researchers will monitor tiny, subtle movements in response to emotional stimuli, along with brain scans…

This study is comparing a new design of breathing tube (called a GMA laryngeal mask) with the standard type used during surgery under general anesthesia. Researchers want to see which tube is easier for doctors to place correctly, provides a better seal, and causes fewer side eff…

This study aims to understand if tiny, involuntary facial expressions (micro-expressions) can help doctors better assess consciousness levels in patients with severe brain injuries. Researchers will show emotional videos and sounds to 200 participants (150 patients and 50 healthy…