First Affiliated Hospital Of Zhejiang University

This study tests a non-invasive brain stimulation method (temporal interference stimulation) aimed at improving metabolism in people with stable bipolar disorder who also have obesity. Researchers will measure changes in key metabolic molecules like GLP-1. The study enrolls 70 ad…

This phase 2 trial is testing a new approach for people with a specific type of rectal cancer that has spread to a few other spots in the body (oligometastases). The treatment combines short-course radiotherapy, chemotherapy (CAPEOX), and an immunotherapy drug called serplulimab …

This phase 3 trial tests whether adding the targeted drug venetoclax to standard chemotherapy (fludarabine and melphalan) before a donor stem cell transplant can improve outcomes for patients over 50 with acute myeloid leukemia or myelodysplastic syndrome. The study will compare …

This study tests whether etamsylate, a drug that helps blood clot, can prevent serious bleeding in people who have low platelets after a stem cell transplant. About 404 adults will receive either etamsylate or a placebo, and researchers will track who has a major bleed or dies wi…

This study tests a drug called orelabrutinib combined with chemotherapy (bendamustine and rituximab or obinutuzumab) in people newly diagnosed with marginal zone lymphoma, a rare blood cancer. The treatment is given in cycles, followed by a maintenance phase with orelabrutinib al…

This study tests a new treatment for adults with a specific type of acute myeloid leukemia (FLT3-ITD AML). The goal is to see if a combination of targeted drugs (gilteritinib, venetoclax, azacitidine) followed by high-dose chemotherapy can control the disease well enough to avoid…

This Phase 2 trial is testing whether combining trastuzumab rezetecan (a targeted drug) with toripalimab (an immunotherapy) before surgery can eliminate more tumor tissue in women with HR-positive, HER2-low breast cancer. About 111 participants will receive the drug combo for 24 …

This phase II trial is testing a combination of two drug regimens—VA (venetoclax and azacitidine) and low-dose CHA (cladribine, homoharringtonine, and cytarabine)—given in alternating cycles to newly diagnosed acute myeloid leukemia (AML) patients aged 60 or older who cannot tole…

This study tests a drug called romiplostim N01 in 130 blood cancer patients receiving a stem cell transplant from a half-matched donor. The drug is given weekly for up to 4 weeks to help platelets recover faster, reducing the need for transfusions and bleeding risk. Half the pati…

This study tests a special stent (flow diverter) to treat brain aneurysms that are hard to treat with standard methods. About 164 adults aged 18-80 with certain types of aneurysms will receive the stent. The main goal is to see if the aneurysm is completely sealed one year after …

This study tests whether adding two targeted drugs (sintilimab and bevacizumab) to standard chemotherapy before surgery can completely eliminate triple-negative breast cancer in 37 women with stage II-III disease. The main goal is to see how many patients have no cancer left at s…

This study tests a new treatment for people with locally advanced rectal cancer that has not spread. The treatment combines short-course radiation, chemotherapy, and two immunotherapy drugs (iparomlimab and tuvonralimab). The goal is to see if this approach can shrink the tumor e…

This phase 2 trial is testing whether adding the immunotherapy drug toripalimab to standard chemotherapy before surgery can improve outcomes for women with triple-negative breast cancer. About 35 participants will receive the combination, then undergo surgery. The main goal is to…

This study tests a drug called gecacitinib (jaktinib) combined with steroids as a first treatment for acute graft-versus-host disease (GVHD), a serious complication after stem cell transplants. About 35 adults who have had a stem cell transplant and develop moderate to severe GVH…

This early-stage trial is testing a new treatment called A-CAR028 for people with acute myeloid leukemia (AML) that has come back or not responded to standard therapy. A-CAR028 is a type of immune cell therapy (CAR-T) that is designed to recognize and attack leukemia cells by tar…

This study tests whether taking a blood thinner (rivaroxaban) plus aspirin after a vein-stenting procedure keeps the vein open longer and prevents new clots. About 172 people with deep vein thrombosis and narrowed iliac veins will receive the combination for 6 months (rivaroxaban…

This study tests whether adding etanercept to the standard drug ruxolitinib can better control severe graft-versus-host disease (GVHD) in people who have had a stem cell transplant. GVHD occurs when donor immune cells attack the recipient's body, and current treatments often fail…

This study tests whether adding the targeted drug venetoclax to standard chemotherapy before a stem cell transplant can help prevent cancer from returning in people with high-risk acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). About 138 participants aged 12 to 6…

This phase 2 trial is testing a combination of three drugs—mitoxantrone liposome, cytarabine, and venetoclax—in 72 adults with acute myeloid leukemia that has come back or not responded to treatment. The goal is to see if this combo can help more patients achieve complete remissi…

This study is testing whether a special type of PET/MRI scan, using a tracer called 18F-FAPI, can accurately diagnose and track myelofibrosis. Researchers will compare the scan results with standard bone marrow biopsies in 57 patients. If the scan works well, it could offer a les…

This study tests a new type of MRI scan to see if it can diagnose prostate cancer more accurately than standard MRI. Researchers will compare the new scan's results with tissue samples from biopsies or surgery. The goal is to find better ways to detect cancer without unnecessary …

This study tests a non-invasive device that uses electrical fields to gently stimulate deep brain areas, aiming to improve depression in people with bipolar disorder. Researchers will compare the real device to a sham version in 160 adults. They will also use brain scans to under…

This study tests whether adding remimazolam to standard sedation (propofol and alfentanil) can lower the risk of low oxygen levels in high-risk patients during painless tracheoscopy. About 360 participants with serious health conditions (ASA class 3-4) will be randomly assigned t…

This study tests a new way to give oxygen during a sedated lung scope (bronchoscopy). Normally, patients can have dangerously low oxygen levels because the scope and sedation block the airway. The new method uses a thin, flexible tube placed through the nose to deliver oxygen dir…

This study compares 12 weeks of supervised dragon boat training to unsupervised home exercise in 72 women who had breast cancer surgery. The goal is to see which approach better improves body composition, physical function, and quality of life. Participants will be randomly assig…

This study looks at whether giving a daily G-CSF shot in the morning or evening helps healthy stem cell donors produce more cells for transplant. About 160 donors will be randomly assigned to receive the shot at 8 AM or 8 PM for 5 days. The goal is to find a simple schedule that …

This study is the first time BY002 is being tested in humans. It aims to check the drug's safety and how the body processes it. Healthy adults will receive either BY002 or a placebo by injection. Researchers will monitor for side effects and measure drug levels in the blood.

This study looks at 200 adults with moderate to severe cancer pain who are taking opioid painkillers like hydrocodone or oxycodone. Researchers will use smartwatches and questionnaires to track pain, sleep quality, and mood over three months. The goal is to understand how pain, i…

This study is developing an AI tool to predict the risk of serious bleeding after stomach cancer surgery. Researchers will collect data from 7,000 adult patients who had their stomach removed due to cancer. The goal is to help doctors decide earlier if a second surgery is needed,…

This study compares a new-generation GMA laryngeal mask with a conventional inflatable mask in patients undergoing elective surgery under general anesthesia. The goal is to see which device is safer, easier to use, and more comfortable for patients. About 1,384 participants will …

This study looks at micro-expressions—tiny, involuntary facial movements—in 200 patients with prolonged disorders of consciousness. Researchers will use emotional stimuli to trigger these expressions and combine them with EEG and MRI scans. The goal is to better classify levels o…

This study looks at very small movements (micro-movements) in patients who have been unconscious for over a month after a severe brain injury. Researchers will use emotional stimuli to see if these movements, along with brain scans, can detect hidden awareness. The goal is to bet…

This study will follow 400 people with early Alzheimer's who are taking the drug lecanemab. Researchers want to see if simple blood tests can detect whether the drug is reducing amyloid plaques in the brain, which is currently measured with expensive PET scans. The goal is to fin…