First Affiliated Hospital Of Zhejiang University

This study tests a new pill, iptacopan, for a rare but serious blood vessel condition called TA-TMA that can happen after a stem cell transplant. The drug aims to block harmful immune system activity and protect blood vessels. About 30 people who have not responded to initial tre…

This study tests a two-step approach to target hidden HIV in the body. First, a drug called chidamide wakes up dormant HIV-infected cells. Then, specially designed natural killer (NK) cells are infused to find and kill those cells. The trial involves 20 adults with HIV who are st…

This study tests a new way to treat a serious tear in the aorta (type B aortic dissection). The standard procedure uses a stent to close the main tear, but blood can still leak into a false channel, causing problems later. This study adds small plugs to block that false channel. …

This study tests if a precise, minimally invasive surgery (stereotactic aspiration) can improve outcomes for people with severe brain stem bleeding compared to standard medical care. The trial will enroll 300 adults with large hematomas and severe symptoms. The main goal is to se…

This study tests a new combination of drugs for adults with diffuse large B-cell lymphoma that has come back or not responded to standard treatments. The goal is to see if adding homoharringtonine and a BCL-2 inhibitor to rituximab and prednisone can safely shrink tumors. About 6…

This study tests a special PET scan (18F-FAPI) to locate the original source of cancers that have spread but have an unknown starting point. Researchers will enroll 120 people with suspected cancer of unknown primary to see how well this imaging method finds the primary tumor and…

This study aims to see if combining a special PET scan (18F-FAPI) with detailed MRI can better diagnose and predict outcomes for people with gastric cancer. Researchers will enroll 230 patients suspected or diagnosed with gastric cancer. The goal is to improve how doctors detect …

This study will test a special PET scan (18F-Octreotide) to see if it can more accurately locate neuroendocrine tumors, guide treatment choices, and predict outcomes. About 152 adults with known or suspected neuroendocrine tumors will receive the scan. The goal is to improve diag…

This study will test a special type of PET/CT scan called 18F-FAPI to see how well it can find lung cancer and predict how the disease will progress. About 120 adults with lung cancer will receive the scan, and researchers will measure its accuracy and other imaging details. The …

This study tests whether a probiotic called Bifidobacterium PB-18 can help adults with mild to moderate depression who are not taking antidepressants. About 88 people will take either the probiotic or a placebo daily for 8 weeks. Researchers will check if symptoms improve and exp…

This study tests a noninvasive magnetic stimulation technique (TMS) targeting brain areas linked to memory and vision. 88 adults with bipolar disorder in a stable phase will receive either real or sham stimulation over 5 days. The goal is to see if this approach safely improves c…

This study tests whether taking inulin (a fiber) and spirulina (a type of algae) can improve sleep in adults aged 18 to 60 with chronic insomnia. 180 participants will be split into four groups: inulin alone, spirulina alone, both together, or a placebo. They will take the supple…

This study looks at 650 adults over 50 having keyhole lung surgery for early-stage lung cancer. During surgery, only one lung is ventilated, which can cause low oxygen and lung problems afterward. Researchers will test different breathing machine settings to see which leads to fe…

This study looks at the discomfort people feel after a procedure to fix a tear or bulge in the main artery (aorta). It will track 132 patients and measure things like back pain, skin irritation from tape, trouble moving, and stress. The goal is to better understand these issues s…

This study looks at brain wave patterns in 48 adults having arm or leg surgery under nerve blocks and sedation. Researchers want to see how different sedative drugs affect brain activity during unconsciousness and recovery. The goal is to better understand anesthesia, not to trea…

This study looks at whether giving a daily G-CSF shot in the morning or evening helps healthy stem cell donors produce more cells for transplant. About 160 donors will be randomly assigned to receive the shot at 8 AM or 8 PM for 5 days. The goal is to find a simple schedule that …

This is a randomized, double-blind, placebo-controlled, parallel-group, prospective, multi-center clinical trial, to evaluate the efficacy of silkworm pupa tablets in improving nutritional status and sarcopenia in patients with malignancies who have completed comprehensive treatm…