First Affiliated Hospital Of Zhejiang University

This study tests whether the drug finerenone can reduce protein in the urine (a sign of kidney damage) in adults with type 2 diabetes and chronic kidney disease. About 148 participants will receive either finerenone or a placebo pill daily for 6 months, on top of their usual medi…

This phase 2 trial compares the drug quetiapine with interpersonal and social rhythm therapy (IPSRT) in 216 people with bipolar II disorder who have disrupted daily rhythms. Participants will be randomly assigned to one of the two treatments for 12 weeks. Researchers will measure…

This early-stage trial tests whether combining two drugs—ibalizumab and chidamide—can safely reduce the hidden HIV reservoir in people living with HIV. The study will enroll up to 29 adults on stable antiretroviral therapy. Researchers will monitor side effects and measure change…

This phase 2 trial tests whether adding a cholesterol-lowering drug (Tafolecimab) to standard immunotherapy (Sintilimab) and chemotherapy (SOX) can shrink tumors in 30 people with advanced pMMR/MSS gastric cancer, a type that usually doesn't respond well to immunotherapy alone. T…

This early-stage trial tests a combination therapy to target hidden HIV reservoirs. Twenty HIV-positive adults on stable antiretroviral therapy will receive chidamide (to reactivate dormant virus) followed by infusions of engineered NK cells designed to kill the reactivated cells…

This study tests a drug called iptacopan in 30 people who have a serious blood vessel problem after a stem cell transplant. The drug aims to block a part of the immune system that damages blood vessels. Researchers will check if it helps patients live longer and recover organ fun…

This study compares robot-assisted surgery to standard medical care for people with a severe brain stem hemorrhage. The trial will enroll 300 patients in China to see if the surgery leads to better recovery and less disability after 3 months. The goal is to provide clear evidence…

This study tests a new way to treat a tear in the aorta (the body's main artery) called type B aortic dissection. The standard repair often leaves small leaks that can cause the artery to widen over time. The new procedure adds a second step: placing small plugs in the false chan…

This study tests a combination of four drugs (homoharringtonine, a BCL-2 inhibitor, rituximab, and prednisone) in 62 adults with relapsed or refractory diffuse large B-cell lymphoma. The goal is to find the safest dose and see if the combo can shrink tumors. It's an early-phase t…

This study will test whether combining a special PET scan (18F-FAPI) with detailed MRI can better detect stomach cancer and its spread. Researchers will compare the accuracy of these scans in 230 people with suspected or confirmed gastric cancer. The goal is to see if this combo …

This study will test a special type of PET/CT scan called 18F-FAPI to see if it can better find where a cancer started when the original source is unknown. About 120 people with cancer of unknown primary will receive the scan, and researchers will measure how accurate it is at de…

This study will test whether a new type of PET scan (18F-FAPI) can more accurately detect lung cancer and help predict patient outcomes. About 120 adults already diagnosed with lung cancer will receive the scan. The goal is to see if this imaging method is better than current tec…

This study will test a new type of PET scan using a radioactive tracer called 18F-Octreotide in 152 people with or suspected of having neuroendocrine tumors. The goal is to see if this scan can more accurately locate tumors, guide treatment decisions, and help predict how the dis…

This study tests a non-invasive brain stimulation method called temporal interference stimulation (TI) to see if it can improve mood in people with depression. Forty-three adults with moderate to severe depression will receive 10 sessions of TI over two weeks. Researchers will us…

This study tests whether taking inulin (a prebiotic fiber) and spirulina (a nutrient-rich algae), alone or together, can improve sleep in adults aged 18 to 60 with chronic insomnia. Over 12 weeks, 180 participants will take one of four options: inulin, spirulina, both, or a place…

This study tests whether a probiotic called Bifidobacterium PB-18 can improve symptoms of mild to moderate depression in adults aged 18 to 65 who are not taking antidepressants. Participants will take either the probiotic or a placebo daily for 8 weeks. Researchers will measure d…

This study tests whether silkworm pupa tablets can improve nutrition and reduce muscle loss (sarcopenia) in people who have completed cancer treatment. 480 participants will receive either the tablets or a placebo for 3 months. The main goal is to see if muscle strength and mass …

This study tests whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can improve memory and thinking in people with bipolar disorder. The trial will involve 88 adults with bipolar disorder who are currently stable. They will receive e…

This study tracks discomfort in 132 people who had endovascular repair for aortic dissection. It measures pain, skin issues, stress, and self-care problems. Some patients will receive extra education after surgery to see if it reduces these symptoms.

This study will monitor brain wave patterns in 48 adults undergoing orthopedic surgery under sedation with one of three drugs: remimazolam, dexmedetomidine, or midazolam. Researchers aim to see how these drugs change brain activity from the start of sedation through recovery. The…

This study looks at the best way to use a breathing machine during lung surgery to prevent lung problems after the operation. It will involve 650 adults over 50 having lung surgery. The goal is to find which breathing settings cause the fewest lung complications like pneumonia or…