New drug combo aims to boost stem cell transplant success in older blood cancer patients
NCT ID NCT07396480
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 trial tests whether adding the targeted drug venetoclax to standard chemotherapy (fludarabine and melphalan) before a donor stem cell transplant can improve outcomes for patients over 50 with acute myeloid leukemia or myelodysplastic syndrome. The study will compare the new three-drug regimen against the standard two-drug regimen in 186 participants. The goal is to reduce relapse and improve survival without increasing severe graft-versus-host disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Venetoclax (a targeted pill) added to fludarabine and melphalan chemotherapy
What this could lead to
If successful, this could become a new standard conditioning regimen before stem cell transplant for older AML/MDS patients, improving long-term survival and reducing relapse.
What could go wrong
This is an early-phase 3 trial with 186 participants, so results are not yet proven. Adding venetoclax may increase side effects like infections or organ toxicity, and the benefit over standard chemo is uncertain.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Jiangsu Province Hospital (The First Affiliated Hospital of Nanjing Medical University)
RECRUITINGNanjing, Jiangsu, China
Contact Email: •••••@•••••
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Nanfang Hospital Southern Medical University
RECRUITINGGuangzhou, Guangdong, China
Contact
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Qilu Hospital of Shandong University
RECRUITINGJinan, Shandong, China
Contact
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Second Affiliated Hospital of Army Medical University (Xinqiao Hospital)
RECRUITINGChongqing, China
Contact Email: •••••@•••••
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Shanghai General Hospital (Shanghai First People's Hospital)
RECRUITINGShanghai, China
Contact
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Sir Run Run Shaw Hospital Zhejiang University School of Medicine
RECRUITINGHangzhou, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Affiliated People's Hospital of Ningbo University
RECRUITINGNingbo, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of Fujian Medical University
RECRUITINGFuzhou, Fujian, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of Ningbo University
RECRUITINGNingbo, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of Wenzhou Medical University
RECRUITINGWenzhou, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine)
RECRUITINGHangzhou, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The First Affiliated Hospital of Zhengzhou University
RECRUITINGZhengzhou, Henan, China
Contact Email: •••••@•••••
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The Second Affiliated Hospital, Zhejiang University School of Medicine
RECRUITINGHangzhou, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
RECRUITINGWuhan, Hubei, China
Contact
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Xiangya Hospital Central South University
RECRUITINGChangsha, Hunan, China
Contact Email: •••••@•••••
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Zhejiang Cancer Hospital & Hangzhou Institute of Medicine, Chinese Academy of Sciences
RECRUITINGHangzhou, Zhejiang, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Zhejiang Provincial Peoples's Hospital
RECRUITINGHangzhou, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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the First Affiliated Hospital, Zhejiang University School of Medicine
RECRUITINGHangzhou, Zhejiang, 311121, China
Contact Phone: •••-•••-•••• Email: •••••@•••••