Triple threat: radiotherapy, chemo, and immunotherapy take on spread rectal cancer
NCT ID NCT06850103
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial is testing a new approach for people with a specific type of rectal cancer that has spread to a few other spots in the body (oligometastases). The treatment combines short-course radiotherapy, chemotherapy (CAPEOX), and an immunotherapy drug called serplulimab before surgery. The goal is to see if this combination can shrink tumors, improve the chance of removing all cancer, and help people live longer without the cancer coming back.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Short-course radiotherapy, CAPEOX chemotherapy (capecitabine and oxaliplatin), and serplulimab (an immunotherapy drug)
- What this could lead to
- If it works, this could offer a new treatment option that shrinks tumors and reduces the chance of cancer coming back in people with rectal cancer that has spread to a few other places.
- What could go wrong
- This is a small, early-phase trial with only 51 participants, so results may not apply to everyone. The combination of treatments may cause significant side effects, and it is not yet known if it will improve survival.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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The First Affiliated Hospital, Zhejiang University School of Medicine
RECRUITINGHangzhou, Zhejiang, 310003, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can diet and vitamin c supercharge rectal cancer treatment?
- A simple blood draw could spot colorectal cancer early
- AI as a surgical Co-Pilot: predicting difficulty in rectal cancer
- A new radiation combo may spare the rectum in early cancer
- Can a Cancer-Fighting virus shrink tumors when chemo fails?
- Can a triple-drug cocktail after short radiation eliminate rectal cancer without surgery?