OBSESSIVE COMPULSIVE DISORDER (OCD)

This study tests a personalized version of deep brain stimulation (DBS) for people with severe obsessive-compulsive disorder (OCD) that hasn't improved with other treatments. Researchers will adjust the stimulation to target specific brain circuits linked to each patient's sympto…

This study tests whether a non-invasive brain stimulation technique called deep transcranial magnetic stimulation (deep TMS) can improve symptoms of obsessive-compulsive disorder (OCD). Researchers will compare two active coils (H7 and H1) against a sham (fake) coil in 96 adults …

This study tests whether a lifestyle program can help people with obsessive-compulsive disorder (OCD) become more active and lower their risk for heart disease and diabetes. Researchers will enroll 108 adults with OCD who are not very active. The program focuses on increasing dai…

This study tests a device called Reclaim DBS, which uses electrical pulses to target brain areas linked to OCD. It's for adults with severe, treatment-resistant OCD who have tried at least three medications and therapy. The goal is to see if it safely reduces obsessive-compulsive…

This study tests whether a type of talk therapy called Exposure and Response Prevention (ERP) can improve daily functioning and quality of life in veterans with obsessive-compulsive disorder (OCD). About half of the 160 participants also have post-traumatic stress disorder (PTSD)…

This study compares two types of employment services for adults with obsessive-compulsive disorder (OCD) who are unemployed and want to work. All 40 participants will receive up to 12 sessions of cognitive behavioral therapy (CBT), and half will also get Individual Placement and …

This study tests whether giving cognitive behavioral therapy (CBT) in person, via video, or a mix of both works best for children aged 5-18 with anxiety or OCD. About 500 kids will be randomly assigned to one of three delivery methods. The goal is to find out which approach impro…

This study tests whether acceptance and commitment therapy (ACT) can help adults with religiously oriented obsessive-compulsive disorder (OCD). Ten participants will receive ACT and be assessed for changes in their OCD symptoms and avoidance behaviors. The goal is to see if this …

This study tests a device that uses gentle electrical fields to stimulate brain areas linked to OCD. 18 adults with moderate-to-severe OCD will receive either real or sham stimulation for 7 days. Researchers will measure symptom changes and use brain scans to understand how it wo…

This study tests a stepped care model for treating anxiety in children and teens aged 7-17. It starts with a low-cost, parent-focused therapy and offers more intensive treatment only if needed. The goal is to make effective care more accessible while reducing costs and therapist …

This study tests a new, faster version of transcranial magnetic stimulation (TMS) for obsessive-compulsive disorder (OCD). Twenty adults with OCD who haven't improved enough with standard treatments will receive six TMS sessions each day for five days. The goal is to see if this …

This study at Yale investigates how people with OCD process fear and safety signals in the brain. Researchers will use mild electrical stimulation (tDCS) to see if it can improve fear extinction learning, which is key to exposure therapy. 180 adults with OCD will undergo brain sc…

This observational study at Yale University is recruiting 200 people who are already taking part in another trial where they may receive a serotonergic psychedelic (like psilocybin or LSD) or a placebo. Researchers want to understand how these substances change the brain's inform…

This pilot study tests whether low-intensity focused ultrasound (LIFU) can safely target brain areas linked to obsessive-compulsive disorder (OCD). Ten adults with chronic OCD will receive single sessions of ultrasound to up to three brain regions. Researchers will measure change…

This study tests whether using a life history calendar—a simple grid that helps people recall important life events—can improve the accuracy of mental health surveys. Researchers in Hong Kong will ask 2,500 adults about their mental health using either a standard interview or one…

This research study collects health information from 10,000 people with brain inflammation conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to find disease subtypes and…

This study is looking for genetic markers linked to a side effect called behavioral activation—feeling overly excited or agitated—that can happen when children and youth take SSRI antidepressants for depression, anxiety, or OCD. Researchers will collect DNA from 160 participants …