Washington University School Of Medicine

This study is testing if a program that helps HIV-positive teenagers save money and learn income skills can improve how well they stick to their daily medication. It involves over 700 teens, aged 10-16, in Uganda. The idea is that reducing financial stress might make it easier fo…

This study is testing whether a three-drug combination (elotuzumab, pomalidomide, and dexamethasone) can help people with multiple myeloma that has returned after their first stem cell transplant. The treatment is given as a long-term 'maintenance' therapy after a second transpla…

This study is testing if taking a pill called duvelisib after a patient's own stem cell transplant can help keep T-cell lymphoma from coming back. The goal is to see if this approach is safe and if it helps patients live longer without their cancer progressing. The trial is for a…

This study is testing whether a personalized vaccine, designed from a patient's own tumor, can help the immune system fight cancer when given alongside an immunotherapy drug (durvalumab). It aims to see if this combination is safe, feasible to make, and can help control the disea…

This clinical trial is testing several different drugs to see if they can slow down or prevent cognitive decline in people who carry genetic mutations that cause inherited Alzheimer's disease. The study includes 490 participants who either have early symptoms or are still symptom…

This study is testing whether a combination of two drugs, dasatinib and quercetin, can slow down accelerated aging in older adults with schizophrenia or treatment-resistant depression. The drugs are taken for just eight days over a month, alongside lifestyle coaching. Researchers…

This study is testing whether a combination of three investigational drugs is safe and effective for people with advanced non-small cell lung cancer whose disease has progressed after prior immunotherapy. The trial will enroll about 30 participants to see if the three drugs worki…

This study is testing a new combination of three drugs—olaparib, pembrolizumab, and carboplatin—as the first treatment for people with advanced head and neck cancer that has returned or spread. The goal is to see if this three-drug mix can shrink tumors better than standard treat…

This study is testing whether a surgery called a nerve transfer can help people with paralysis in all four limbs (tetraplegia) regain some use of their hands and arms. Surgeons will reroute healthy nerves from a working muscle to connect to a paralyzed muscle below the injury. Th…

This early-stage trial is testing if adding an experimental pill called TTI-101 to a targeted form of radiation (SBRT) is safe and can help control pancreatic cancer for longer. It's for adults with borderline or locally advanced pancreatic cancer who have already completed stand…

This study is testing whether adding a new immunotherapy drug (TSR-042) to standard radiation treatment is safe and effective for people with endometrial (uterine) cancer who cannot have surgery. It will involve about 10 participants to first check for side effects. The goal is t…

This study is testing a new, highly focused radiation technique for men with high-risk prostate cancer. The goal is to see if delivering a strong, precise dose of radiation directly to the main tumor and surrounding areas is safe and can be done effectively. Researchers will clos…

This study is testing four different combinations of existing drugs to find safer and more effective treatments for onchocerciasis, also known as river blindness. Researchers in Liberia are working with 300 adults who have the infection to compare how well these drug combinations…

This trial is testing whether adding an experimental anti-tau drug (E2814) to an approved anti-amyloid drug (lecanemab) can better slow the progression of Alzheimer's disease in people who have a specific genetic mutation that causes it. It involves about 200 participants, some w…

This early-stage study is testing the safety and immune response of a personalized DNA vaccine combined with an immunotherapy drug (retifanlimab) for adults newly diagnosed with an aggressive type of brain cancer called unmethylated glioblastoma. The vaccine is custom-made for ea…

This study is testing if adding a drug called ramucirumab to the immunotherapy drug pembrolizumab works better than pembrolizumab alone for people with advanced head and neck cancer that has returned or spread. The goal is to see if the combination helps shrink tumors and control…

This study is testing whether group prenatal care is better than traditional one-on-one visits for pregnant women with type 2 or gestational diabetes. It will compare how well each approach helps control blood sugar during pregnancy and manage weight after giving birth. The goal …

This study is testing a new combination of two drugs for people with follicular lymphoma who have not yet received any treatment. The goal is to see how well the drugs work together to shrink or eliminate the cancer. One drug helps the body's immune cells find and kill cancer cel…

This study is testing a two-drug combination for adults with advanced head and neck cancer that has spread or returned and has gotten worse despite prior immunotherapy. The goal is to see if adding a chemotherapy drug (nab-paclitaxel) to an immunotherapy drug (nivolumab) can shri…

This early-stage study is testing the safety and initial effectiveness of combining two drugs, acalabrutinib and durvalumab, for adults with primary central nervous system (CNS) lymphoma, a rare and aggressive cancer of the brain or spine. The trial is for patients whose cancer h…

This study is testing if combining three different cancer drugs works better than standard care for advanced soft tissue sarcoma that has spread. It will involve about 105 adults whose cancer has worsened after one or two prior treatments. The goal is to see if this combination c…

This study is testing whether just three radiation sessions can effectively treat early-stage breast cancer, instead of the usual weeks of treatment. It's designed for women over 50 with low-risk cancer who've had breast-conserving surgery. The goal is to see if this faster appro…

This study tested if adding a new drug called PD 0332991 to a standard hormone therapy (anastrozole) could better control early-stage breast cancer before surgery. It involved 84 women with a specific type of breast cancer that is hormone-sensitive. The main goal was to see if th…

This study is testing a two-step treatment for a rare and aggressive skin cancer called angiosarcoma. First, patients receive a chemotherapy drug (paclitaxel) for several weeks, then they continue that drug while also receiving radiation therapy. The goal is to shrink the tumor a…

This study tests whether giving patients a special type of 'memory-like' immune cell after a half-matched bone marrow transplant can help keep leukemia from coming back. It's for adults with high-risk acute myeloid leukemia that hasn't responded well to standard treatments. Resea…

This study is testing if a minimally invasive catheter procedure can help people with severe, long-term leg problems caused by old blood clots. About 225 participants with significant pain, swelling, or ulcers will be randomly assigned to receive either the new procedure plus sta…

This study is testing whether the drug cabozantinib can help control aggressive neuroendocrine tumors that have returned after initial treatment. Researchers will enroll 35 adults whose cancer has progressed despite previous therapies to see if cabozantinib shrinks tumors and ext…

This early-stage trial is testing a new three-part treatment for people with intermediate or high-grade soft tissue sarcoma in the arms, legs, or trunk. Before surgery, participants receive a new drug called ADI-PEG 20 along with a standard chemotherapy (ifosfamide) and radiation…

This study is testing a different way for teens with asthma to use their inhalers. Many teens forget to take their daily preventive medicine, which leads to more asthma attacks and hospital visits. Researchers are comparing the usual daily inhaler routine against a new plan where…

This study is testing whether combining two existing drugs, ramucirumab and pembrolizumab, works better than pembrolizumab alone for advanced head and neck cancer that has returned or spread. The first part of the study aims to find a safe dose for the combination. The second par…

This study is testing whether a combination of short radiation therapy and chemotherapy can completely eliminate rectal cancer tumors, allowing patients to avoid major surgery. Researchers are enrolling 63 adults with early to mid-stage rectal cancer to see if this approach relia…

This study is testing if taking an oral drug called duvelisib after receiving CAR-T cell therapy can help the engineered immune cells survive longer in the body and work better. It will involve about 42 adults with certain types of lymphoma or leukemia who are already scheduled t…

This study is testing whether a new drug called rhIL-7-hyFc can safely increase the number of infection-fighting white blood cells in people with aggressive brain tumors. The trial involves 42 patients who have already received standard radiation and chemotherapy. The main goal i…

This study aimed to test whether giving doctors AI-powered risk alerts about patients after surgery could help prevent serious complications. The system would identify high-risk patients and notify their care teams, potentially allowing earlier intervention. The trial was withdra…

This study is testing a three-drug treatment called IRD given after a patient's own stem cell transplant for multiple myeloma. The goal is to help patients stay disease-free for a longer time after their transplant. After the initial treatment, patients receive ongoing 'maintenan…

This study is testing a two-step stem cell transplant for adults with high-risk non-Hodgkin's lymphoma. First, patients receive a transplant using their own cells, followed by a second, gentler transplant using cells from a matched donor. The goal is to see if this combined appro…

This study is testing if adding an experimental drug called defactinib to a precise form of radiation therapy (SBRT) can better control advanced pancreatic cancer that cannot be surgically removed. After initial chemotherapy, 42 participants will be assigned to receive either the…

This early-stage study is testing whether delivering one chemotherapy drug directly into the abdomen, while giving two others by mouth and vein, is safe and tolerable for people with advanced abdominal cancer from colorectal or appendix tumors. The treatment is given after surger…

This is a small, early-stage study testing a personalized vaccine designed to train the immune system to fight a specific type of aggressive brain cancer called glioblastoma. The main goals are to see if creating and giving this custom vaccine is safe and possible, and to check i…

This study aims to find the most effective combination of support methods to help young people with HIV in Uganda stay on their medication and achieve viral suppression. Researchers are testing four different components—financial training, savings accounts, educational cartoons, …

This study is testing a less intense stem cell transplant procedure for children and young adults with rare disorders where the immune system doesn't work properly. The goal is to use a milder treatment to help the patient's body accept the donor's healthy immune cells with fewer…

This early-stage study is testing a new drug called tulmimetostat (DZR123) in patients with advanced mycosis fungoides or Sézary syndrome, which are types of skin lymphoma. The main goal is to check if the drug is safe and to find the right dose for future studies. Researchers wi…

This study is testing a three-drug combination for adults with advanced small cell or non-small cell lung cancer whose initial treatment is no longer working. The first part of the study aims to find the safest and most effective dose. The second part will see how well this combi…

This study is testing the drug lecanemab in people who have a genetic form of Alzheimer's disease and have already been in a related long-term trial. The main goal is to see if aggressively removing amyloid plaque from the brain years before symptoms typically appear can signific…

This early-stage study is testing whether adding a new immunotherapy drug called mosunetuzumab to standard chemotherapy is safe and effective for adults with aggressive B-cell lymphoma that has returned or not responded to prior treatment. The trial will enroll 24 participants to…

This study is testing whether providing families with financial support and parenting skills training can improve children's behavioral health. It involves 967 children in Uganda, aged 10-14, who are experiencing behavioral challenges. Families are assigned to receive either fina…

This study aimed to see if adding a weight loss medication (semaglutide) to a standard hormonal IUD treatment works better than the IUD alone for premenopausal women with obesity and a condition called endometrial hyperplasia (abnormal uterine lining). The goal was to help these …

This study is testing if adding a nutrient called choline to a special ready-to-eat food helps children with moderate malnutrition get better and prevents them from deteriorating into severe, life-threatening malnutrition. It will involve 1,500 young children in Malawi, who will …

This study is testing if adding an investigational drug called APL-101 to the standard first-line treatment (osimertinib) can help control advanced lung cancer for a longer period. It is for adults whose cancer has a specific genetic change (EGFR mutation) and has not worsened af…

This study is testing whether tracking specific cancer-related genetic mutations in patients' blood can help doctors better predict who is at high risk of their leukemia returning. Researchers are following 107 adults with acute myeloid leukemia (AML) who are in remission after i…

This study is testing a combination of three cancer drugs (cisplatin, nab-paclitaxel, and cetuximab, called CACTUX) for people with incurable head and neck cancer that has spread or returned. The main goal is to see if this combination can help control the cancer for a longer tim…

This study is testing a different way to use asthma inhalers for people who have trouble remembering to take their daily preventive medication. Instead of requiring daily use, the new approach lets patients use a combination inhaler only when they have symptoms, while researchers…

This study is testing different support strategies to help teenagers and young adults with HIV in Kenya stay engaged with their medical care and keep their virus under control. It will enroll 880 participants aged 14-24. The research compares methods like text message reminders, …

This study is testing a special group prenatal care program designed to support African-American women at high risk for depression during and after pregnancy. It aims to see if this supportive group setting can reduce depression, stress, and problems like preterm birth. If succes…

This study is testing whether a medication called denosumab, which is normally used for bone health, can reduce dense breast tissue in premenopausal women. Dense breast tissue is a known risk factor for developing breast cancer. Researchers hope that by lowering breast density, t…

This study aims to prevent child abuse and neglect by identifying newborns at higher risk. Researchers are testing if providing personalized education and actively helping families connect to community support services—like parenting classes or mental health care—is more effectiv…

This study is testing if two common heart medications can prevent heart damage in people receiving a specific type of breast cancer treatment. It involves a small group of patients with HER2-positive breast cancer who are starting or recently started their cancer therapy. The goa…

This study is testing two versions of a personalized risk tool called RiskProfile to see if they help doctors and patients work together better on lung cancer prevention. One tool uses standard health information, while the other adds genetic risk information. The goal is to see …

This study is testing a new community-designed campaign to prevent HPV-related cancers in Nigeria. It aims to increase HPV vaccination rates for girls aged 9-14 and encourage HPV screening for their mothers or female caregivers. The campaign was created with input from local comm…

This study is testing two ways to help undernourished pregnant women in Sierra Leone have healthier pregnancies and babies. It is giving some women a special nutritional food with added brain-healthy fats and nutrients, while others get a standard food, to see if it helps prevent…

This study tests whether rhythm-based training using music or singing can improve walking problems in people with Parkinson's disease. For 12 weeks, participants will practice walking to music or walking while singing to see which approach works better. Researchers will measure w…

This study compares two approaches to help young children (ages 3-7) with emotional and behavioral difficulties. School counselors will deliver either a 6-8 week video therapy program (THRIVE) for children and caregivers or provide access to an online parenting course. Researcher…

This study is comparing two different shoulder replacement surgeries for people with arthritis in their shoulder joint. Researchers want to see whether a partial replacement or a full replacement provides better long-term pain relief and shoulder function. Participants will be ra…

This study is testing if letting children listen to their favorite music before and after a common ear tube surgery can help them wake up more calmly from anesthesia. Researchers are comparing 160 children aged 3-9 who either receive standard care or listen to personalized music.…

This study is testing two different training methods to help people with Parkinson's disease who have mild memory problems. The goal is to improve their ability to remember to do everyday tasks, like taking medication or attending appointments. About 120 participants will complet…

This study was designed to see if a future, larger trial would be possible. It planned to test a combination treatment for low-income women with depression after a C-section. The treatment involved two ketamine injections and several talk therapy sessions in the days after birth,…

This study is comparing a new robotic-assisted surgical technique for partial knee replacement against traditional methods. It aims to see if using a robot helps place the implant more precisely and leads to less pain and better recovery for people with knee arthritis. The resear…

This study compares two approaches to manage pain after shoulder replacement surgery. Researchers want to see if a single-dose topical medication applied during surgery works as well as a continuous nerve-block catheter that delivers pain medication for days after surgery. The st…

This study is testing a special recovery plan for children and young adults having major bladder reconstruction surgery. The plan, called Enhanced Recovery After Surgery (ERAS), aims to help patients recover faster with less pain and a shorter hospital stay. Researchers will comp…

This study aimed to test if a personalized online education program could help patients and their caregivers feel more prepared for major head and neck cancer surgery. It planned to see if the program improved patient satisfaction and reduced the need for unplanned hospital visit…

This study is testing whether inhaling nitrous oxide (laughing gas) can quickly reduce suicidal thoughts in hospitalized patients with severe depression. Fifty patients will receive either the gas or a placebo during up to six sessions while continuing their standard depression t…

This study aims to understand how puberty and changes in sex hormones, like testosterone, influence pain sensitivity and migraine symptoms in adolescents. Researchers are comparing 100 teens aged 11-15, some with migraines and some without, to see how their hormone levels relate …

This study aims to develop new ways to measure and understand myofascial pain (chronic muscle pain). Researchers are comparing 52 people—half with active neck/shoulder/back pain and half without—using three different scanning techniques during a single visit. The goal is to find …

This study aims to understand why storing fat around organs like the liver affects some people's health more than others, potentially leading to conditions like diabetes and heart disease. Researchers are comparing lean and obese individuals, some with and some without metabolic …

This study aimed to test if adding visual information pages to consent forms improves the experience for cancer patients considering clinical trials. It measured patient knowledge, anxiety, and trust before and after the visual aids were used. The study was withdrawn before any p…

This study aims to understand why some people with obesity develop related health problems like diabetes while others stay healthy. Researchers are comparing three popular weight-loss diets—Mediterranean, low-carb, and very-low-fat plant-based—in 180 participants with obesity. Th…

This study aims to discover if certain genes make a person more likely to develop prostate cancer and, if they do get it, more likely to have it spread. Researchers are collecting DNA, blood, and tissue samples from nearly 2,000 men with prostate cancer to analyze their genes. Th…

This study aims to find better ways to predict whether Crohn's disease treatments will work. Researchers are following 112 adults with small bowel Crohn's who are starting new biologic medications. They're testing whether MRI scans and special blood protein tests taken early in t…

This study aims to understand how brain wave patterns during and after electroconvulsive therapy (ECT) relate to changes in depression symptoms. Researchers are monitoring 31 adults with treatment-resistant depression who are already scheduled for ECT. By measuring specific brain…

This study aims to understand how vitamin D levels might influence high blood pressure in people with type 2 diabetes. Researchers will take blood samples from 40 participants to examine a specific type of white blood cell. They want to see if these cells from people with low vit…

This study examines how sharing personalized 5-year Alzheimer's disease risk estimates affects healthy older adults. Researchers gave 450 participants without memory problems risk reports based on their brain scans, blood tests, and genetics. They measured how this information im…

This study aims to understand the role of specific immune cells, called dendritic cells, in the development of skin graft-versus-host disease (GVHD) after a bone marrow transplant. Researchers will collect and analyze small skin samples from 22 adult patients who have either acut…

This study aims to understand how long the body's immune defense lasts after getting the JYNNEOS vaccine, which protects against diseases like monkeypox and smallpox. Researchers will measure immune cells and antibodies in the blood, lungs, skin, and bone marrow of 20 healthy adu…

This study aims to improve hip surgery for a painful condition called femoroacetabular impingement (FAI), which often affects young, active people and military personnel. Researchers are following 747 patients who had surgery to identify which patient characteristics, disease fea…

This study aims to see if testing cancer cells in a lab dish can predict which chemotherapy drugs will work best for patients with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). Researchers will collect blood samples from 80 adults before and after they start st…

This study aims to understand how the body processes different types of meals in people with obesity, and how that changes after significant weight loss. Researchers will compare the metabolic effects of a low-carbohydrate meal and a standard meal. They will study 30 adults befor…

This study aims to understand how blood flow and oxygen use in the brain differ between healthy people and those with blood vessel problems. Researchers will use MRI scans while participants breathe air with controlled levels of oxygen and carbon dioxide through a special mask. T…

This study aims to understand how gentle electrical stimulation of the ear nerve affects brain waves in healthy children. Researchers will monitor 10 children's brain activity, heart rate, and comfort levels during a 30-minute stimulation session. The goal is to gather basic safe…