Washington University School Of Medicine

This early-stage trial tests whether a DNA vaccine targeting mammaglobin-A (a protein found on breast cancer cells) is safe and can boost the immune system against cancer. About 27 adults with ER+, HER2- breast cancer will receive the vaccine while undergoing standard hormone the…

This early study tested a personalized DNA vaccine in 9 people with a newly diagnosed, aggressive type of brain cancer called glioblastoma. The vaccine was custom-made for each person based on their tumor's unique genetic makeup. The main goals were to see if the vaccine was safe…

This study tests a combination of three drugs (elotuzumab, pomalidomide, and dexamethasone) given after a second stem cell transplant for people whose multiple myeloma has returned. The goal is to see if this treatment can keep the cancer from progressing for as long as possible.…

This study tests a treatment called extracorporeal photopheresis (ECP) for lung transplant patients who develop bronchiolitis obliterans syndrome (BOS), a condition where the airways narrow and breathing gets harder. About 280 Medicare-eligible adults will receive ECP, where bloo…

This study tests whether senolytic drugs—which clear out aged, damaged cells—are safe and feasible for people with early Alzheimer's or mild cognitive impairment. About 48 adults aged 60 and older with elevated tau protein will receive either the drug or a placebo. The main goal …

This study looks at a new way to use asthma inhalers for people who often forget or choose not to take their daily maintenance medication. Instead of using a daily controller inhaler, participants will use a combination inhaler only when they have symptoms. The goal is to see if …

This study tests whether using an inhaler only when symptoms occur works as well as taking daily maintenance inhalers for teens with asthma who often skip their daily medication. About 40 participants will use an electronic sensor to track how often they use their inhaler. The go…

This study tests four different types of support—financial training, savings accounts, a cartoon-based adherence program, and mentorship from HIV-experienced role models—to see which combination best helps youth (ages 11-17) with HIV keep the virus under control. About 576 partic…

This study tests a three-drug combination (ixazomib, lenalidomide, and dexamethasone) given after a stem cell transplant to people with multiple myeloma. The goal is to see if this treatment can keep the cancer away longer. After four cycles, participants receive one of two maint…

This study tests whether adding choline (a nutrient found in eggs) to a special food supplement helps children aged 6-59 months with moderate acute malnutrition avoid getting worse. About 1500 children in Malawi will receive either the standard supplement or one with extra cholin…

This study tests whether adding the drug mosunetuzumab to standard chemotherapy is safe and effective for people with aggressive B-cell lymphoma that has come back or not responded to prior treatment. About 24 adults will receive one of two chemotherapy backbones plus mosunetuzum…

This study tests whether a combination of two drugs, dasatinib and quercetin, can safely slow accelerated aging in 40 older adults with treatment-resistant depression or schizophrenia. Participants must be 50 or older and have age-related health conditions. The main goal is to se…

This study looks at whether attending prenatal care in a group setting helps pregnant women with type 2 or gestational diabetes better control their blood sugar and lose pregnancy weight after giving birth. About 117 women will be randomly assigned to either group care or traditi…

This early-phase study tests a drug called ADI-PEG 20 combined with chemotherapy (ifosfamide) and radiation before surgery for soft tissue sarcoma. The goal is to find the safest dose and see if it helps shrink tumors. Only 6 patients with intermediate or high-grade sarcomas of t…

This study tests whether adding two immunotherapy drugs (nivolumab and ipilimumab) to the targeted therapy cabozantinib can shrink tumors better than cabozantinib alone in people with advanced soft tissue sarcoma. About 105 participants whose cancer has spread or cannot be remove…

This study tests a new way to deliver radiation to the prostate and nearby lymph nodes in men with high-risk or unfavorable intermediate-risk prostate cancer. The approach uses MRI to find the exact tumor location and gives a higher dose there. The goal is to see if this method i…

This study is for people with small cell or non-small cell lung cancer whose cancer has worsened after initial treatment. It tests a combination of three drugs: ADI-PEG 20, gemcitabine, and docetaxel. The first part finds the safest dose, and the second part checks how well the c…

This study looks at whether helping HIV-positive teenagers save money and start small businesses can improve their ability to take their HIV medication every day. The study involves 702 teens aged 10-16 in Uganda. The idea is that financial stability may give them more hope and m…

This study tests whether adding the experimental drug APL-101 to the standard treatment osimertinib can help control EGFR-mutated non-small cell lung cancer that has spread. About 27 adults with advanced lung cancer who have already started osimertinib will receive the combinatio…

This study tests whether adding ramucirumab to pembrolizumab works better than pembrolizumab alone for people with advanced head and neck cancer that has come back or spread. About 37 adults with PD-L1 positive cancer will take part. The goal is to see if the combination shrinks …

This study compares two types of shoulder replacement surgery for people with glenohumeral osteoarthritis (wear-and-tear arthritis in the shoulder joint). One surgery replaces only the ball of the joint with a modern pyrocarbon implant, and the other replaces both the ball and so…

This study tests whether giving the chemotherapy drug paclitaxel before and during radiation therapy can help people with a rare and aggressive skin cancer called cutaneous angiosarcoma. The goal is to shrink the tumor before surgery and improve how long patients live without the…

This study tests a combination of three drugs (zimberelimab, domvanalimab, and etrumadenant) in 30 adults with advanced non-small cell lung cancer who have already tried immunotherapy. The goal is to see if the triple therapy can shrink tumors or slow cancer growth. Researchers a…

This study tests an experimental drug called rhIL-7-hyFc in people with high-grade glioma, a type of brain cancer. The goal is to see if the drug can safely increase the number of infection-fighting white blood cells (lymphocytes) that often drop after standard radiation and chem…

This study tests whether adding a targeted drug (PD 0332991) to standard hormone therapy (anastrozole) before surgery can better stop breast cancer cell growth in women with early-stage ER+ HER2- breast cancer. About 84 participants will receive the combination for several weeks …

This study tests whether adding a drug called defactinib to targeted radiation therapy can help control advanced pancreatic cancer better than radiation alone. About 42 people with inoperable pancreatic cancer will take part. The goal is to see if the combination slows cancer gro…

This study tests a chemotherapy drug called CPX-351 in 20 adults aged 18-70 with high-risk myelodysplastic syndrome (MDS) who are eligible for a stem cell transplant. The main goal is to see if the drug is safe and tolerable at two different dose levels. Researchers will also tra…

This early-phase study tests adding an immunotherapy drug (TSR-042) to standard radiation for people with early-stage endometrial cancer who cannot have surgery. The goal is to see if the combination is safe and can help the immune system attack the cancer more effectively. Ten p…

This study tests a personalized vaccine (made from each patient's unique tumor markers) combined with the immunotherapy drug durvalumab in people with extensive-stage small cell lung cancer. The goal is to see if this combination is safe and can slow cancer growth. Only 6 partici…

This early-phase study tests whether adding the drug duvelisib after CAR T-cell therapy can help the immune cells stay active longer and reduce side effects like cytokine release syndrome. About 42 adults with non-Hodgkin lymphoma or acute lymphocytic leukemia will take part. The…

This study tests a combination of two drugs, mosunetuzumab and polatuzumab vedotin, in people with untreated follicular lymphoma, a type of blood cancer. The drugs work together to help the immune system find and kill cancer cells. The main goal is to see how many patients have t…

This study tests whether helping families with money and parenting skills can improve behavior in children aged 10-14 who have oppositional defiant disorder or conduct disorder. About 900 children and their caregivers in Uganda will be split into three groups: one gets financial …

This study tests a three-drug combination called CACTUX (cisplatin, nab-paclitaxel, and cetuximab) in 74 adults with incurable head and neck cancer that has spread or come back. The goal is to see how well the treatment controls the disease and what side effects occur. Participan…

This study is testing a mobile app called Suubi-Mhealth for Ugandan youth aged 14-17 who have both HIV and depression. The app uses cognitive-behavioral therapy (CBT) to help improve mood and make it easier to stick with HIV medication. The goal is to see if the app can reduce de…

This study tests whether nerve transfer surgery can help people with complete spinal cord injuries regain hand and arm function. About 70 adults aged 18-65 who have been injured for at least 3 months but less than 36 months will take part. The surgery moves working nerves to rest…

This study tests a stem cell transplant for children and young adults up to age 28 with serious immune system disorders. The goal is to replace their faulty immune cells with healthy donor cells using a milder chemotherapy-like preparation to reduce side effects. The study tracks…

This study tests the drug lecanemab in 40 people who have a genetic form of Alzheimer's disease. The goal is to see if removing amyloid plaques from the brain can delay the start of symptoms or slow the disease. Participants previously received another anti-amyloid drug and will …

This study tests whether giving patients special 'memory-like' natural killer (NK) cells after a stem cell transplant can help keep acute myeloid leukemia (AML) away. It includes 60 adults with AML that did not respond to or came back after standard treatments. The goal is to see…

This early-phase study tests a personalized DNA vaccine combined with an immunotherapy drug (retifanlimab) in 27 people with a fast-growing type of brain cancer called unmethylated glioblastoma. The vaccine is custom-made to target unique markers on each person's tumor, aiming to…

This early-phase study tests a new drug called tulmimetostat (DZR123) in 24 adults with advanced mycosis fungoides or Sezary syndrome, rare types of skin lymphoma. Participants must have already tried at least one prior treatment. The main goals are to check the drug's safety and…

This study looks at whether robotically-assisted partial knee replacement leads to better pain scores and recovery compared to standard total knee replacement. About 95 adults with knee osteoarthritis will use a smartphone app to report pain and opioid use weekly. The goal is to …

This study tests a two-step stem cell transplant for people with high-risk non-Hodgkin's lymphoma. First, patients receive their own stem cells, followed by a donor transplant to boost long-term disease control. The trial includes 18 adults aged 18 to 70 with relapsed or hard-to-…

This early-phase study tests a combination of two drugs (acalabrutinib and durvalumab) for people with primary central nervous system lymphoma, a rare brain cancer. The study includes up to 25 patients whose cancer has returned or who cannot receive standard chemotherapy. The mai…

This study tests whether experimental drugs can slow down memory and thinking problems in people who have a genetic mutation that causes Alzheimer's disease. About 490 adults aged 18-80 with a family history of early-onset Alzheimer's will receive either the study drug or a place…

This early-phase trial tests a new drug (TTI-101) combined with a precise type of radiation (SBRT) for people with pancreatic cancer that cannot be removed by surgery right away. The goal is to see if this combination is safe and can help keep the cancer from growing for longer. …

This study tests whether a special food supplement with added omega-3s and choline can help undernourished pregnant women in Sierra Leone carry their babies longer and improve their babies' brain development. It also tests a new talk therapy program to reduce depression during an…

This study tested a combination of two drugs—nab-paclitaxel (a chemotherapy) and nivolumab (an immunotherapy)—in 46 adults with advanced head and neck cancer that had stopped responding to a prior immunotherapy. The goal was to see if the combo could shrink tumors or slow disease…

This study was designed to see if combining a weight-loss drug (semaglutide) with a hormone-releasing IUD could help premenopausal women with obesity and a precancerous uterine condition keep their uterus and avoid cancer. It planned to enroll women who wanted to preserve their f…

This study tests whether adding the immunotherapy drug nivolumab to standard chemotherapy before surgery can improve the immune system's ability to fight triple-negative breast cancer. The trial involves 15 people with early-stage (stage II or III) disease. Researchers are measur…

This study tests the drug cabozantinib in 35 adults with high-grade neuroendocrine tumors that have worsened after at least one prior treatment. The goal is to see if the drug can shrink tumors and help people live longer. Cabozantinib works by blocking signals that help tumors g…

This study compares a single dose of radiation to five doses after breast cancer surgery for people with very early-stage breast cancer. The goal is to see if one dose works just as well at preventing the cancer from coming back, while also reducing side effects and improving qua…

This study tests whether combining certain drugs can safely and effectively treat onchocerciasis (river blindness) in adults. Participants first receive ivermectin to clear skin and eye parasites, then get one of four drug combinations. The goal is to find a regimen that kills ad…

This early-phase study tests a new way to deliver chemotherapy directly into the abdomen after surgery for cancer that has spread to the lining of the belly. It includes 21 adults with appendix or colon cancer. The goal is to find the safest dose and see if the treatment helps co…

This early-stage trial tests a new treatment called WU-CART-007 for people with certain blood cancers (like acute myeloid leukemia and T-cell lymphoma) that have not responded to standard therapy. The treatment uses donor immune cells that are specially modified to target and kil…

This study looks at whether a catheter-based procedure can help people with long-term leg pain, swelling, or ulcers caused by old blood clots in the deep veins. About 225 adults with disabling symptoms will either get the procedure plus standard care or standard care alone. The g…

This study tests ways to help 880 adolescents and young adults with HIV in Kenya stay engaged in their care. Participants first get either standard care or electronic navigation. If they miss a visit, they are reassigned to standard care, peer support, or cash incentives. The goa…

This study tests whether adding an experimental drug (E2814) to a standard Alzheimer's treatment (lecanemab) can slow memory loss and brain changes in people who have a genetic mutation that causes Alzheimer's. About 197 adults aged 18-80 with mild symptoms or no symptoms but car…

This study tests a three-drug combination (olaparib, pembrolizumab, and carboplatin) as a first treatment for people with head and neck cancer that has come back or spread. The goal is to see if this mix shrinks tumors better than the current standard therapy. About 30 adults wit…

This study tests a three-step treatment plan for people with a type of head and neck cancer not linked to HPV. First, patients receive a drug called palbociclib before standard chemoradiation, then they get more palbociclib after treatment. The goal is to see if this approach hel…

This study compares two standard treatments for stage I non-small cell lung cancer: surgery and a precise type of radiation called stereotactic body radiation therapy (SBRT). About 446 patients will be followed for up to 3 years to see which treatment leads to better survival and…

This study tests whether denosumab, a drug used for bone health, can reduce breast density in premenopausal women with dense breasts. Dense breasts are a known risk factor for breast cancer. The trial involves 210 women and aims to see if lowering breast density could open new wa…

This study tests a new community-designed campaign to help prevent HPV, a virus that can cause cancer. About 1,838 mother-daughter pairs in Nigeria will take part. The campaign aims to increase HPV vaccination for girls and HPV self-testing for mothers, using ideas crowdsourced f…

This study looks at whether giving new parents extra, personalized help can prevent child maltreatment. Researchers will follow about 150 families from before birth until the baby is 18 months old. Some families will get the extra support, while others will get standard care. The…

This study tests whether rivastigmine, a drug used for Alzheimer's, can help people with severe confusion and agitation caused by poisoning from certain medications. About 42 participants aged 10 and older will receive either rivastigmine or a placebo. The goal is to see if rivas…

This study is testing whether adding nitrous oxide (laughing gas) to standard hospital care can quickly reduce suicidal thoughts in people with severe depression. About 50 adults with major depression and active suicidal thinking will be randomly assigned to receive either nitrou…

This study tests a group prenatal care program called EleVATE GC for African-American women at high risk for postpartum depression. The program aims to reduce depression, preterm birth, and low birthweight. About 416 pregnant women will participate, and if successful, the model c…

This study tests whether playing a child's favorite music before and during ear tube surgery can reduce confusion and agitation when they wake up. About 160 children aged 3 to 9 will take part. Researchers will compare kids who hear personalized music to those who do not, using s…

This study looks at whether a special recovery plan called ERAS helps children and young adults (ages 4 to 26) heal faster after bladder reconstructive surgery. The plan focuses on better pain control and quicker recovery. Researchers will compare how long these patients stay in …

This study tests a 6-8 week therapy program called THRIVE for children ages 3-7 who have emotional or behavioral difficulties. School counselors deliver the program to children and their caregivers either online or at school. The goal is to improve children's behavior and emotion…

This study tests whether a topical medication called ZYNRELEF, applied during shoulder replacement surgery, can control pain better than the standard nerve block with a catheter. About 86 adults having shoulder replacement will be randomly assigned to one of the two methods. Rese…

This study looks at whether a cochlear implant helps children aged 4 to 14 with hearing loss in one ear hear better than a hearing aid. About 80 kids will use a hearing aid first, then get a cochlear implant. Researchers will compare word recognition and hearing in noise before a…

This study tests two types of memory training for people with Parkinson's disease and mild memory problems. 120 participants will complete 8 training sessions over 8 weeks and be followed for a year. The goal is to see if these programs improve everyday memory and help people rea…

This study looks at whether proton beam therapy, a precise form of radiation, causes fewer severe side effects than standard radiation (IMRT) for people with esophageal cancer. About 22 patients with stage II or III esophageal cancer will receive proton therapy, and researchers w…

This study uses a special brain scan called PIB PET to look at different types of dementia in people with Parkinson's disease. The goal is to find out who might develop dementia and what causes it. Researchers will study 320 participants to better understand these brain changes.

This study looks at why storing fat in and around organs like the liver affects some people's health more than others. Researchers will measure insulin sensitivity and inflammation in 144 lean and obese adults. The goal is to better understand these differences to help develop fu…

This study looks at 112 people with small bowel Crohn's disease who are starting a new biologic therapy. Researchers use MRI scans and blood protein tests to see if early changes can predict who will be in remission without steroids after one year. The goal is to help doctors cho…

This study looks at whether testing cancer cells in a lab can predict how well chemotherapy will work for people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Researchers will collect blood samples from 80 adults before treatment and test them against diffe…

This study looks at how long the JYNNEOS vaccine (used for smallpox and monkeypox) stays effective. Researchers will measure immune responses in the blood, lungs, skin, and bone marrow of 20 healthy adults aged 18-60 who have never had the vaccine or monkeypox before. The goal is…

This study aimed to see if adding simple visual summaries to consent forms helps cancer patients better understand and feel less anxious about joining clinical trials. It was designed for adults with cancer who were already considering a trial. However, the study was withdrawn be…

This study involves 450 healthy adults aged 65 and older who have no memory problems. Researchers give them their personal 5-year risk estimate for Alzheimer's dementia based on brain scans and genetic tests. The goal is to measure how this information affects their mood, thinkin…

This study looks at why some people with obesity develop conditions like type 2 diabetes and heart disease while others do not. Researchers will compare three popular weight loss diets—Mediterranean, low-carb, and very-low-fat plant-based—in 180 adults with obesity. The goal is t…

This study aims to understand how the immune system remembers vaccines over time. Twenty-five healthy adults will receive four FDA-approved vaccines at once and provide blood and bone marrow samples for up to two years. The goal is to measure antibody levels and track immune cell…

This study compares two methods of rolling out a program called Bridges, which teaches financial skills and provides support to young people ages 11-17 who lost parents to AIDS. About 1,440 students from 48 schools in Uganda will take part. The goal is to see which method works b…

This study looks at how different types of immune cells (dendritic cells) in the skin are involved in graft-versus-host disease (GVHD) after a bone marrow transplant. Researchers will collect skin samples and blood from 22 adults with acute or chronic skin GVHD to analyze cell ty…

This study follows nearly 2,000 men with newly diagnosed prostate cancer to see if certain genes make the cancer more likely to spread. Researchers collect blood or tissue samples to analyze genetic markers. The goal is to better understand who is at higher risk, not to test a ne…

This study aimed to see if a personalized online education program could help patients and their caregivers feel more prepared before and after major head and neck surgery, and reduce trips back to the hospital. The program was designed for adults undergoing free flap surgery or …

This study explores how changing sex hormone levels during puberty relate to migraine pain in adolescents aged 11 to 15. Researchers will measure pain sensitivity and hormone levels in 100 teens with and without migraines. The goal is to better understand the link between hormone…

This study uses MRI scans to watch how the brain's blood vessels expand and contract when people breathe different gas mixtures. Researchers will compare healthy adults and patients with brain blood vessel diseases to understand differences in blood flow and oxygen use. Participa…

This study looks at how safe and tolerable a mild nerve stimulation (taVNS) is in 10 healthy children, and whether it changes their brain waves. Participants get one 30-minute session while their heart rate, oxygen, and brain activity are monitored. The goal is to gather basic sa…

This study looks at how electroconvulsive therapy (ECT) affects brain wave patterns in 31 adults with treatment-resistant depression. Researchers measure depression symptoms and brain activity during and after ECT sessions to find links. The goal is to better understand why ECT w…

This study looks at how the body handles different types of meals in African American and white adults with obesity. Researchers compare responses before and after weight loss from a low-calorie diet or gastric bypass surgery. The goal is to understand changes in insulin, blood s…

This study tests three new radioactive dyes (tracers) that light up tau tangles in the brain on PET scans. Researchers want to see which tracer works best to tell apart people with Alzheimer's from healthy older adults. About 38 volunteers aged 50-100 will get up to three scans. …

This study aims to find new ways to measure myofascial pain using advanced imaging techniques like MRI. Researchers will compare 52 participants—some with chronic muscle pain and some healthy—to identify biological markers that could help diagnose and understand this condition be…

This study looks at how vitamin D levels might influence high blood pressure in people with type 2 diabetes. Researchers will examine immune cells (monocytes) from 40 participants to see if they trigger a hormone that raises blood pressure. The goal is to better understand the co…

This study tests whether using a visual consent form with pictures and simple language helps patients better understand research studies for cancer and Alzheimer's disease. Researchers will compare the standard consent process to the new visual approach with 266 patients and rese…

This study was designed to see if combining ketamine injections with talk therapy could help low-income women with depressive symptoms after a C-section. The goal was to check if a larger future study was possible. However, the study was withdrawn before any participants were enr…

This study tests a program for refugee families living in the U.S. It combines family group sessions with virtual teen mentoring to help reduce emotional and behavioral problems like PTSD, depression, and anxiety in teens. About 308 teens and their parents will take part. The goa…

This study aims to measure inflammation in the brains of people with Parkinson disease using a new radioactive tracer called [11C]-CS1P1 during a PET scan. Researchers believe this inflammation may contribute to movement and thinking problems. The study will compare 80 participan…

This study aims to find out which patient traits, disease features, and surgical techniques lead to the best outcomes after hip surgery for femoroacetabular impingement (FAI). About 747 young adults and military personnel who have failed conservative treatment will be followed. T…

This study looks at whether checking for specific genetic mutations in patients with acute myeloid leukemia (AML) after chemotherapy can better predict their risk of relapse. About 107 adults aged 18-60 with intermediate-risk AML will have their blood or bone marrow tested for le…

This study planned to test whether giving doctors machine learning predictions about patient risk could reduce serious complications after surgery, like unplanned ICU stays or death. It was designed for adults at high risk, but the study was withdrawn before any participants were…

This study looks at sleep health in 50 pregnant women with low income. Researchers will use a home sleep test and a wrist monitor to measure sleep. They want to see how sleep relates to heart health and social factors. The goal is to create better sleep guidelines and treatments …

This study tests whether giving doctors and patients a personalized risk report (based on clinical or genetic info) increases lung cancer screening and smoking cessation. About 915 patients and their primary care doctors are taking part. The goal is to see if tailored feedback he…