New combo offers hope for head and neck cancer that resists immunotherapy

NCT ID NCT04831320

First seen Jan 10, 2026 · Last updated May 12, 2026 · Updated 19 times

Summary

This study tested a combination of two drugs—nab-paclitaxel (a chemotherapy) and nivolumab (an immunotherapy)—in 46 adults with advanced head and neck cancer that had stopped responding to a prior immunotherapy. The goal was to see if the combo could shrink tumors or slow disease progression better than historical results. Participants received the drugs intravenously, and researchers measured tumor response and how long the benefit lasted.

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Contacts and locations

Locations

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.