Can two old drugs turn back the clock on aging in mental illness?
NCT ID NCT05838560
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a combination of dasatinib and quercetin, two drugs that clear out aging cells, can safely slow down accelerated aging in older adults with treatment-resistant depression or schizophrenia. Forty participants aged 50 and older will take the drugs and be monitored for safety and tolerability. The goal is to see if this approach can reduce the physical health problems that often come with these mental disorders.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
dasatinib and quercetin
What this could lead to
If it works, this could point toward a way to slow down aging-related health problems in people with serious mental disorders.
What could go wrong
This is a small, early-phase trial with only 40 people, so results may not apply widely. The drugs can have side effects like fluid retention or low blood counts.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Washington University School of Medicine
St Louis, Missouri, 63110, United States