Washington University School Of Medicine

This early-stage trial is testing whether dapagliflozin (Farxiga), a drug used for diabetes and heart failure, is safe and tolerable when taken for four weeks before prostate removal surgery in men with localized prostate cancer. The study will also look for signs that the drug m…

This phase 2 trial tested the drug duvelisib (Copiktra) as a maintenance therapy after an autologous stem cell transplant in 17 people with T-cell lymphoma. The goal was to see if it could safely delay the cancer from coming back. The study was terminated early, so the full resul…

This small, early-stage trial tested a combination of a steroid spray (triamcinolone) and a decongestant spray (oxymetazoline) to help people who were dependent on decongestants stop using them. The study planned to slowly reduce the decongestant dose while keeping the steroid st…

This study tested whether the epilepsy drug zonisamide could prevent hearing damage in police officers after shooting range training. Only 3 people enrolled before the study was stopped early. The goal was to see if the drug could reduce hearing loss measured by hearing tests and…

This study tested whether adding the drug vorolanib to standard maintenance therapy with atezolizumab could help people with extensive-stage small cell lung cancer stay cancer-free longer after initial chemotherapy. Only 11 participants were enrolled before the study was terminat…

This study tested a precise type of proton radiation (IMPT) for people whose rectal cancer came back after prior radiation. The goal was to find the highest safe dose without causing severe side effects. The trial enrolled 15 adults and was terminated early.

This study tested a new imaging technique called AWSM-PET/CT that adds a few minutes to a standard PET/CT scan to get clearer pictures of small cancer spots. Researchers planned to enroll cancer patients to see if the new method improved accuracy. However, the study was stopped e…

This study tested whether adding photoacoustic imaging to standard ultrasound can better tell if an ovary is cancerous or benign. Researchers aimed to reduce the number of women who have surgery to remove an ovary that turns out to be non-cancerous. The study enrolled 185 women s…

This pilot study aimed to see if giving heart medications (carvedilol and empagliflozin) to women starting HER2-targeted therapy for breast cancer could prevent heart damage. The study planned to enroll 20-40 participants but was terminated early after enrolling only 7. The goal …

This small pilot study tested a noninvasive brain stimulation technique called tDCS in 5 adults with major depression that hadn't improved after at least 3 antidepressant trials. Participants received up to 20 sessions of higher-than-usual electrical current over 4 to 6 weeks. Th…

This pilot study tested whether combining repetitive transcranial magnetic stimulation (rTMS) with computerized cognitive training could help adults with schizophrenia who have thinking and memory problems. Twelve participants received either active or sham rTMS followed by cogni…

This study looked at whether desipramine, a medication that affects brain regions involved in pain processing, could help people with irritable bowel syndrome (IBS). Researchers planned to use brain scans to see how the drug changes pain signals in the brain. Only 18 people were …

This study tested whether a nasal spray version of the migraine drug Ketorolac, combined with oral Prochlorperazine and Diphenhydramine, could relieve migraine pain in children as effectively as the standard IV treatment. The trial aimed to enroll children aged 4 and older with m…

This study tested a school-based program called Proud & Empowered, designed to help LGBTQ students cope with minority stress and improve mental health. About 228 high school students took part. The program was led by school counselors and social workers. The study was terminated …

This study looked at whether giving teenagers a numbing medicine (lidocaine) through an IV during and after spine surgery could lower their need for strong painkillers (opioids) and help them recover faster. The trial planned to include 15 teens aged 12-18 with scoliosis, but it …

This study tested whether a visual consent form with pictures helps patients with cancer or Alzheimer's understand research better than standard text. Researchers planned to enroll 266 adults across three U.S. sites. The trial was terminated early, so results may be limited.

This study looked at whether providing support for unmet basic needs—like food, housing, or transportation—helps low-income women attend their colposcopy appointment after an abnormal cervical cancer screening. The trial planned to enroll 72 participants but was stopped early wit…

This study aimed to compare how the immune system responds to two different seasonal flu vaccines given at the same time. Healthy adults aged 18-49 who had not received a flu shot in at least three years were eligible. The study was terminated early and only enrolled 2 participan…

This study aimed to find a better way to detect pelvic floor problems caused by radiation treatment for gynecologic cancer. Researchers tested a 5-minute single-digit pelvic exam on 22 patients undergoing chemoradiotherapy for cervical cancer. The goal was to see if this exam cou…