Needle-Free migraine relief for kids? nasal spray cocktail tested in ER

NCT ID NCT06083571

Terminated Symptom relief Sponsor: Washington University School of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a nasal spray version of the migraine drug Ketorolac, combined with oral Prochlorperazine and Diphenhydramine, could relieve migraine pain in children as effectively as the standard IV treatment. The trial aimed to enroll children aged 4 and older with migraines in the emergency department. However, the study was terminated early after enrolling only 41 participants, so the results are not conclusive.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ketorolac (nasal spray), Prochlorperazine (oral), Diphenhydramine (oral)
What this could lead to: If it worked, this could offer children with migraines a needle-free way to get fast pain relief in the emergency room.
What could go wrong: The trial was terminated early with only 41 participants, so results are limited. It is unclear if the nasal spray works as well as the standard IV treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

migraine disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEADACHE, MIGRAINE

Contacts and locations

Locations

Washington University in St. Louis

St Louis, Missouri, 63110, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.