Washington University School Of Medicine

This phase 2 trial tests whether adding an experimental drug called tovecimig to standard chemotherapy (FOLFIRI) can shrink tumors or slow cancer growth in people with metastatic colorectal cancer who have already tried one prior treatment. The study will enroll 25 participants a…

This early-phase trial is testing whether a personalized cancer vaccine, made from a patient's own tumor, can safely boost the immune system's ability to fight triple negative breast cancer. About 30 newly diagnosed patients will receive the vaccine along with standard chemothera…

This early-phase study tests a new drug (ATRN-119) combined with a standard chemotherapy (decitabine) in 27 adults with acute myeloid leukemia or high-risk myelodysplastic syndrome that has a TP53 gene change. The main goals are to find a safe dose and see if the combo can shrink…

This study tests a new approach for recurrent glioblastoma, an aggressive brain cancer. It combines a minimally invasive laser that heats and destroys tumor tissue (LiTT) with an immunotherapy drug called cemiplimab, which helps the immune system attack cancer cells. About 99 par…

This study tests whether adding lovastatin, a common cholesterol-lowering drug, can help the cancer treatment trastuzumab deruxtecan work better in people with HER2-low or ultralow advanced breast cancer. About 60 participants will receive both drugs to see if more tumors shrink …

This study tests a combination of an experimental drug (ficerafusp alfa), an immunotherapy (pembrolizumab), and targeted radiation before surgery for people with advanced head and neck cancer that is HPV-negative. About 45 participants will receive these treatments over several w…

This study tests a new combination of three drugs (nivolumab, ipilimumab, and nogapendekin alfa inbakicept) for people with stage IV or recurrent non-small cell lung cancer. The goal is to see if this treatment helps keep the cancer from growing longer than standard two-drug ther…

This study tests whether a single pill containing four standard heart failure medications can help patients take their medicines more regularly and reduce hospitalizations and death. About 1,656 adults with heart failure and reduced pumping function will be randomly assigned to r…

This study will test a program based on WHO guidelines to improve diabetes screening and care in 10 primary health centers in Nigeria. About 2,800 adults with or at risk for diabetes will take part. The goal is to see if the program helps more people get diagnosed and treated.

This study compares two weight management programs for children who have had acute lymphoblastic leukemia (ALL). About 80 children and their caregivers will be randomly assigned to either a basic educational program or a more intensive guided self-help program. The goal is to see…

This early-phase study tests whether adding an experimental drug (DSP-0390) to the immunotherapy atezolizumab can safely help prevent extensive stage small cell lung cancer from growing back after initial chemotherapy and immunotherapy. About 20 adults whose cancer did not worsen…

This study tests whether a special earpiece that stimulates the vagus nerve can help people with a type B aortic dissection. The device is used for 20 minutes twice a day for two weeks. Researchers will check if it lowers inflammation and helps control blood pressure. Sixty adult…

This phase 2 trial tests giving short course radiation therapy along with standard chemotherapy before surgery for stomach cancer. The goal is to see if this total neoadjuvant therapy leads to a higher rate of complete cancer disappearance, with fewer side effects than traditiona…

This pilot study tests whether a carefully supervised ketogenic diet can help people with Marfan syndrome who have a chronic aortic dissection avoid surgery for one year. Fifteen adults aged 18-50 will follow the diet with guidance from a dietitian, measure their blood ketones at…

This study tests whether adding a glutaminase inhibitor (telaglenastat) to standard chemoradiation helps people with advanced cervical cancer live longer without the disease getting worse. About 42 adults with stage III–IVA cervical cancer will receive the drug alongside standard…

This study expands a successful blood pressure program to 50 primary health centers across five Nigerian states. Over 10,000 adults with high blood pressure will receive simplified care from trained non-physician health workers, following the WHO HEARTS package. The goal is to im…

This study tests a new radioactive tracer called 64Cu-DOTA-ECL1i that aims to make PET scans more accurate for head and neck cancer. Researchers will enroll 90 adults with newly diagnosed or recurrent/metastatic head and neck squamous cell carcinoma. The goal is to see if this tr…

This study looks at whether adding an MRI to the yearly mammogram can help find breast cancer earlier in women with dense breasts. Participants will have a mammogram and a risk score calculated from it. Those with a high risk score will be offered an MRI. The goal is to see if th…

This study tests a 12-week program where a person with traumatic brain injury and a close supporter work with a therapist to improve communication and emotional support. The goal is to reduce isolation and improve health. The study involves 60 participants and focuses on whether …

This study will test whether psilocybin, the active ingredient in magic mushrooms, can help treat depression. Fifty adults with depression will receive a 25 mg capsule of synthetic psilocybin along with therapy. Researchers will use MRI brain scans and other tests to see how psil…

This study tests a 12-session group program called ENGAGE-TBI for adults who had a traumatic brain injury (TBI) at least 6 months ago. The program, led by an occupational therapist and a TBI survivor, focuses on social skills and problem-solving. Researchers want to see if it's p…

This study tests if a nebulized steroid (budesonide) delivered via the NasoNeb device is safe and effective for chronic rhinosinusitis. 50 adults with the condition will be randomly assigned to receive either nebulized budesonide or a standard steroid lavage. The main goal is to …

This study will test a smartphone chatbot called Wysa that delivers cognitive-behavioral therapy-based self-help for adults with eating disorders. 800 participants will use the chatbot daily for eight weeks. The goal is to see if this digital tool can reduce eating disorder sympt…

This early study tests whether asciminib, a drug already approved for leukemia, can get into brain tumors in children and young adults (ages 6-25) with recurrent brain tumors. Some participants will also get sildenafil to see if it helps the drug enter the tumor. The main goal is…

This study looks at whether taking bicalutamide for two weeks can make PSMA PET/CT scans better at finding small amounts of prostate cancer that standard scans might miss. It involves 20 men with recurrent prostate cancer and very low PSA levels. Participants are randomly assigne…

This study tests whether a culturally tailored program can help Black women keep their mammogram appointments. About 176 women aged 40 and older who are scheduled for a screening mammogram will take part. The goal is to find better ways to reduce racial disparities in breast canc…

This study tests a new imaging technique called low-count quantitative SPECT (LC-QSPECT) to see how the drug Radium-223 spreads in men with advanced prostate cancer. About 38 men who are already eligible for Radium-223 will get extra scans after their treatment. The goal is to se…

This early study tests whether a single injection of motixafortide can help reveal tiny amounts of leukemia cells that remain after initial chemotherapy in people with acute myeloid leukemia (AML). Ten adults who have completed 1-2 cycles of treatment will receive the drug and th…

This study looks at fat that builds up inside muscles as people age, which may cause inflammation and damage. Researchers will have 16 older adults (ages 65-80) do a 12-week calf exercise program. Before and after, they will measure muscle strength, take CT scans, and analyze sma…

This study looks for proteins in the blood that might show early heart changes in women with preeclampsia, a serious pregnancy condition. Researchers will also use heart ultrasounds to see how the heart changes during pregnancy. The goal is to find ways to predict future heart pr…

This study looks at how partnerships between universities and local health departments can help put proven cancer prevention programs into action. Researchers will survey 364 health workers and academics across the U.S. to find out what works best. The goal is to learn how to mak…

This study tests a program to improve how hospital staff communicate when caring for children with cancer in low-resource settings. The program includes training and new protocols for teamwork. Researchers will measure changes in communication quality over six months. Only 8 hosp…