Washington University School Of Medicine

This study tests whether adding a drug called telaglenastat (CB-839) to standard chemoradiation can help people with advanced cervical cancer live longer without the disease getting worse. About 42 adults with stage III-IVA cervical cancer will receive the combination treatment. …

This study tests whether adding a drug called NT-I7 to standard CAR-T cell therapy can help the immune cells stay active longer in people with multiple myeloma that has come back or not responded to treatment. About 52 participants will receive either NT-I7 or a placebo after the…

This early-phase study tests an oral drug called PMD-026 in 18 adults with myelofibrosis, a rare bone marrow disorder. The drug targets a protein (RSK1) to reduce spleen swelling and improve symptoms. Participants must have already tried a JAK inhibitor without success. The main …

This early-stage trial tests a combination of a vaccine targeting a common virus (CMV) and an immunotherapy drug (nivolumab) in children and young adults with aggressive brain tumors like diffuse midline glioma and medulloblastoma. The goal is to see if this approach is safe and …

This study tests a new combination of three drugs (ipilimumab, nivolumab, and nogapendekin alfa inbakicept) as a first treatment for people with stage IV or recurrent non-small cell lung cancer. The goal is to see if this triple therapy helps keep the cancer from growing longer t…

This study tests whether adding a short course of radiation to standard chemotherapy before surgery can improve outcomes for people with early-stage stomach cancer. About 20 adults will receive this combination, then have surgery or monitoring. The goal is to see if this approach…

This pilot study tests whether a carefully supervised ketogenic diet can help 15 adults with Marfan syndrome who have a chronic aortic dissection. Participants will follow the diet for 12 months while continuing their usual medications. The main goal is to see if the diet helps t…

This study tests whether giving three treatments together before surgery can improve outcomes for people with advanced head and neck cancer. Participants will receive radiation, an immunotherapy drug (pembrolizumab), and an experimental drug (ficerafusp alfa) before standard surg…

This study tests two experimental drugs, CTX-009 and CTX-471, in people whose glioblastoma has returned after standard treatment. The goal is to see if the drugs are safe and can help control the tumor and extend survival. About 54 adults with up to two recurrences will take part…

This study tests whether a single pill containing four standard heart failure medications can help people with a weak heart pump (ejection fraction 40% or less) live longer and avoid hospital stays. About 1,656 adults in Sri Lanka will either receive the polypill or usual care, a…

This early study tests whether asciminib, a drug approved for leukemia, can get into brain tumors in children and young adults (ages 6-25) with recurrent brain tumors. Some participants will also receive sildenafil to see if it helps more drug enter the tumor. The main goal is to…

This early-phase study tests whether adding an experimental drug (DSP-0390) to standard maintenance immunotherapy (atezolizumab) can help keep extensive-stage small cell lung cancer from progressing. About 20 adults whose cancer did not worsen after initial chemotherapy plus immu…

This early-phase study tests a personalized cancer vaccine (PCI) alone or with an immune-boosting drug (AB248) in 30 people newly diagnosed with triple negative breast cancer. The vaccine is custom-made from each patient's tumor. The main goal is to see if the approach is safe an…

This study compares two weight management programs for children who have had acute lymphoblastic leukemia (ALL) and their caregivers. One program provides basic educational materials, while the other offers a more guided family-based approach. The goal is to help these children m…

This study tests a non-invasive device that stimulates a nerve in the ear to see if it can reduce inflammation and help control blood pressure in people with a type B aortic dissection. Sixty adults with this condition will receive the stimulation while in the ICU. The goal is to…

This program aims to expand a proven system for managing high blood pressure (hypertension) to more areas of Nigeria. It will enroll up to 10,000 adults with high blood pressure across five new states. The goal is to improve long-term control of blood pressure by training more he…

This study looks at whether a special mammogram risk score can help decide which women with dense breasts should get an MRI after a normal mammogram. About 78 women aged 25-55 with dense breasts and a higher risk score will be invited for MRI. The goal is to see if this approach …

This study tests a new 3D imaging device (SkinScan3D) to see if it can measure Kaposi Sarcoma skin lesions more accurately and consistently than the current manual method using rulers. Researchers will compare the two methods in 300 adults with confirmed Kaposi Sarcoma who are st…

This study tests a new approach to help people with early Parkinson's disease who have mild thinking or memory problems. Instead of doing computer brain games, participants work with an occupational therapist to learn practical strategies for everyday challenges, like remembering…

This study tests if a nebulized steroid spray (budesonide via NasoNeb) is safe and works better than standard steroid rinses for chronic rhinosinusitis. About 50 adults with the condition will be randomly assigned to one of two treatments. The main goal is to see if symptoms impr…

This study tests an automated chatbot designed to help adults with eating disorders reduce their symptoms. Researchers will enroll 800 people who have a clinical or subclinical eating disorder and are not currently in treatment. The chatbot provides digital support through a smar…

This study is testing whether a program called ENGAGE-TBI can be successfully delivered to adults with traumatic brain injury (TBI) in the St. Louis area. The goal is to help people who have had a TBI more than 6 months ago and are struggling to take part in social activities. Re…

This study aims to find proteins in the blood that may show early heart changes in pregnant women with preeclampsia, a condition involving high blood pressure. Researchers will use heart ultrasounds and blood tests at two points during pregnancy to see how these markers relate to…

This study looks at whether fat that builds up inside muscles as people age causes damage and inflammation. Researchers will have 16 older adults (ages 65-80) do a 12-week calf exercise program. They will measure muscle strength, take CT scans, and analyze small muscle samples to…

This study looks at how partnerships between universities and local health departments can help put cancer prevention programs into practice. Researchers will survey 364 health workers and academics across the U.S. to find out what works best. The goal is to learn how to make the…

This study tests whether a single injection of motixafortide can help find leftover leukemia cells (called measurable residual disease, or MRD) in the blood of people with acute myeloid leukemia (AML) who have finished their first round of chemotherapy. Ten adults who are in remi…

This study tests a new device that tracks a patient's breathing movements during radiation therapy for cancers in the chest or upper abdomen. The goal is to see if the system can accurately guide the radiation beam without needing backup methods. About 20 adults will participate,…

This study looks at ways to improve how healthcare teams talk to each other in hospitals that treat children with cancer but have limited resources. The goal is to see if better communication can help doctors and nurses work together more effectively, which may lead to better car…

This study aims to see if a special type of scan (low-count quantitative SPECT) can accurately measure where the drug Radium-223 goes in the body. Radium-223 is a radioactive treatment for prostate cancer that has spread to bones, but doctors don't know exactly how much reaches t…

This study looks at whether a new genetic test called ChromoSeq® can quickly and accurately classify leukemia in children and young adults (under 30) with acute lymphoblastic leukemia (ALL). Researchers will collect bone marrow or blood samples from 60 participants at diagnosis a…

This study tests a culturally tailored program to help Black women keep their mammogram appointments. Researchers will compare no-show rates between women who get the program and those who don't. The goal is to find better ways to reduce racial disparities in breast cancer screen…