Washington University School Of Medicine

This program aims to expand a proven system for managing high blood pressure (hypertension) to more areas of Nigeria. It will enroll up to 10,000 adults with high blood pressure across five new states. The goal is to improve long-term control of blood pressure by training more he…

This early-stage study is testing whether adding an experimental drug called NT-I7 to standard CAR-T cell therapy helps control multiple myeloma for longer. The research will involve 40 adults with myeloma that has returned or stopped responding to other treatments. Participants …

This study is testing whether adding two oral drugs (defactinib and avutometinib) to a precise form of radiation therapy can better control advanced pancreatic cancer and keep it from getting worse. It will involve about 36 adults whose cancer has not progressed after initial che…

This study is testing if adding an experimental drug called telaglenastat (CB-839) to the standard chemoradiation treatment helps people with advanced cervical cancer live longer without their cancer getting worse. It will enroll 42 adults with newly diagnosed, advanced cervical …

This small pilot study is testing whether a carefully supervised ketogenic diet can help stabilize the aorta in people with Marfan syndrome who have a chronic aortic dissection. Fifteen participants will follow the diet for a year while researchers track their blood ketone levels…

This study is testing whether a new motion monitoring system can help deliver radiation therapy more accurately to cancers in the chest and upper abdomen. These areas move with breathing, making precise treatment challenging. The research will involve 20 patients receiving standa…

This study aims to find the better way to give a chemotherapy drug called 5-FU to people with advanced head and neck cancer that has worsened after two standard treatments. It will compare giving the drug for two days every two weeks versus four days every three weeks. The main g…

This study tests two different family-based programs designed to help children who have survived acute lymphoblastic leukemia (ALL) maintain a healthy weight. The programs involve both the child and their primary caregiver, comparing a basic educational approach with a more struc…

This study is testing a new combination of treatments for early-stage stomach cancer. It adds a shorter course of radiation to standard chemotherapy, all given before surgery. Researchers hope this approach will more completely eliminate the tumor and cause fewer severe side effe…

This study is testing a new combination treatment for children and young adults with aggressive brain cancers that have returned or are newly diagnosed. The treatment combines a vaccine designed to train the immune system to attack the cancer with a drug (nivolumab) that helps th…

This study is testing a new drug called ONT01 combined with standard chemotherapy (gemcitabine and nab-paclitaxel) for people with metastatic pancreatic cancer that has worsened after their first treatment. The goal is to see if this combination can better control the cancer by c…

This early-stage study is testing two new drugs, CTX-009 and CTX-471, for people whose aggressive brain cancer (glioblastoma) has returned after standard treatment. Researchers want to see if using CTX-009 alone or combined with CTX-471 is safe and can help control the tumor and …

This study aims to find the best combination of therapy techniques for a smartphone chatbot designed to help adults with binge or purge eating disorders. Researchers will test four different therapy components with 800 participants to see which ones work best together. The goal i…

This study is testing whether adding a new immune-boosting drug (nogapendekin alfa inbakicept) to two existing cancer immunotherapy drugs (nivolumab and ipilimumab) works better for advanced non-small cell lung cancer. Researchers will enroll 26 patients with stage IV or recurren…

This early-stage study is testing an experimental oral medication called PMD-026 for people with myelofibrosis, a serious bone marrow cancer. The trial will first find the safest dose and then check if the drug can reduce spleen size and ease symptoms like fatigue and pain. It's …

This early-stage trial is testing whether adding an experimental drug called emavusertib to standard chemotherapy and immunotherapy helps people with advanced bile duct cancer. Researchers will first find the safest dose, then see how well the combination works to control cancer …

This early-stage trial will test the safety and feasibility of a personalized cancer vaccine for people newly diagnosed with triple negative breast cancer. The vaccine is custom-made for each patient based on their tumor. Researchers will also test if adding an experimental immun…

This early study aims to see if a drug called asciminib, already approved for leukemia, can get into brain tumors in high enough amounts to potentially treat them. It will involve about 12 young patients (ages 6-25) whose brain tumors have come back. Researchers will test ascimin…

This study is testing a new approach to help women with dense breast tissue. It uses a computer model to analyze mammogram images and calculate a personal breast cancer risk score. Women with a high score will be offered an MRI scan to see if this extra test finds cancers that a …

This study is testing whether mailing at-home HPV test kits helps more women get screened for cervical cancer. Researchers will enroll 100 women who are overdue for screening and send them self-collection kits. The main goal is to see how many women return the kits and complete f…

This study is testing whether a new genetic sequencing test called ChromoSeq® can provide faster and more accurate diagnosis for children and young adults with acute lymphoblastic leukemia (ALL). Researchers will collect blood and bone marrow samples from 60 patients to see if th…

This study is testing a new program that teaches practical thinking strategies to help people with early Parkinson's disease manage daily memory and thinking problems. 114 participants will work with a therapist to learn personalized techniques, like using checklists or planning …

This study is testing a web-based tool called CARE that helps cancer patients understand treatment costs, health insurance, and find financial resources. Researchers will enroll 430 patients with gynecologic, prostate, lung, or colorectal cancer to see if using the tool reduces f…

This study aims to test whether delivering a steroid medication through a special nasal nebulizer machine is safe and effective for treating chronic sinusitis symptoms. It will compare this new method against the standard approach of mixing the steroid into a sinus rinse bottle. …

This is a small, early-stage study to see if a single injection of a drug called motixafortide can help doctors find very small amounts of leftover leukemia cells in the blood. The study involves adults with acute myeloid leukemia (AML) who are in remission after initial chemothe…

This study aims to discover early warning signs in the blood that may indicate heart changes in women with preeclampsia, a serious pregnancy complication. Researchers will follow about 172 pregnant women in Nigeria, using heart ultrasounds and blood tests at two points during pre…

This study is testing a new type of medical scan to see if it can accurately measure where a prostate cancer treatment called Radium-223 goes in the body. Researchers want to see if this scan is practical, safe, and if its measurements relate to other signs of the disease. The go…

This study is testing a new type of PET scan to see if it can provide a clearer picture of inflammation inside brain tumors. Adults with a primary brain tumor or cancer that has spread to the brain will get one or two of these special scans. The goal is to learn if this scan can …

This study aims to understand how sleep affects heart health in pregnant women with low incomes. Researchers will measure sleep patterns at home using wrist monitors and breathing tests in 50 participants. The goal is to gather information to create better sleep screening and sup…

This study tests a training program designed to improve how doctors, nurses, and other staff communicate with each other in hospitals treating children with cancer in low-resource settings. It aims to see if better teamwork and communication can improve patient care and survival.…

This study aims to find the best ways to help university researchers and local public health departments work together more effectively. It will test different support strategies for these partnerships to see which helps them implement more proven cancer prevention and control pr…