Washington University School Of Medicine

This study in Kenya tests different behavioral strategies to help 880 adolescents and young adults (ages 14-24) with HIV stay engaged in care. Participants first get either standard care or electronic navigation. If they miss appointments or have unsuppressed virus, they are re-r…

This study tested whether giving babies one egg daily along with teaching parents about responsive feeding, nutrition, and hygiene can improve growth and development. 600 infants in Haiti were split into three groups: standard care, eggs only, or eggs plus the parenting program. …

This study tested a combination of two drugs, ramucirumab and pembrolizumab, in 43 people with head and neck cancer that had spread or come back. The goal was to first find a safe dose and then see if the combination could shrink tumors. The approach aims to block blood vessel gr…

This phase 2 trial tested whether adding the immunotherapy drug pembrolizumab (Keytruda) to standard surgery, radiation, and chemotherapy could help prevent head and neck cancer from coming back. The study enrolled 67 adults with advanced, surgically removable head and neck squam…

This phase 1 trial tested a personalized vaccine made from each patient's unique cancer mutations (neoantigens) combined with an immune booster (poly-ICLC) in 33 people with pancreatic cancer. The vaccine was given after standard chemotherapy, either before or after surgery. The …

This study tested a new way to give radiation to people with early-stage breast cancer. Instead of many sessions, patients received just three doses aimed only at the tumor area. The goal was to see if this shorter treatment is safe and works well. 77 patients took part, and the …

This study tested whether helping people with type 2 diabetes address unmet basic needs—like food, housing, and safety—can improve their blood sugar control. About 473 adults on Medicaid received either a 6-month navigation program or usual care. The goal was to see if this suppo…

This study tested whether a short course of radiation followed by chemotherapy could eliminate the need for surgery in people with early-stage rectal cancer. 63 patients were enrolled, and the treatment aimed for a complete clinical response, meaning no tumor could be found on ex…

This study tested a new way to deliver high-dose radiation to small lung tumors in just one day, instead of the usual two to three weeks. Ten patients with early-stage lung cancer or limited lung metastases received a single session of stereotactic body radiotherapy (SBRT) using …

This study tested a new approach for children and adults whose acute myeloid leukemia (AML) came back after a stem cell transplant. Researchers gave patients a special type of immune cell called cytokine-induced memory-like natural killer (CIML NK) cells, along with donor immune …

This study tested whether giving less intense treatment after surgery for HPV-related throat cancer can reduce side effects like weight loss and the need for a feeding tube. 63 patients had surgery and then received either lower-dose radiation or no radiation, depending on their …

This study tested a combination of four drugs (acalabrutinib, bendamustine, rituximab, and cytarabine) as a first treatment for people with mantle cell lymphoma, a rare blood cancer. The goal was to see if this approach could safely improve remission rates before a stem cell tran…

This phase 2 trial tested the drug crizanlizumab in 18 people with RVCL, a rare and fatal genetic condition that damages small blood vessels in the brain and eyes. There is currently no treatment for RVCL. The study measured changes in brain lesions on MRI scans to see if the dru…

This early study tested the drug belimumab (Benlysta) to see if it could prevent chronic graft-versus-host disease (GvHD) in 10 adults who had a stem cell transplant for blood cancer. GvHD is a serious condition where the donor's immune cells attack the patient's body. The main g…

This study tested a mobile app (uMAT-R) designed to help pregnant and postpartum women with opioid use disorder stay on their medication and treatment. 125 women participated in a pilot trial to see if the app was easy to use and helped reduce cravings and improve attitudes towar…

This small pilot study tested whether combining intravenous ketamine with a specific talk therapy called RO DBT is safe and feasible for adults with treatment-resistant depression. Sixteen participants received four weekly ketamine infusions plus four months of RO DBT. The main g…

This early study tested a combination of the immunotherapy drug pembrolizumab (Keytruda) and internal radiation (brachytherapy) in 16 people with metastatic esophageal cancer. The goal was to see if the radiation could help the immune system attack the cancer more effectively. Th…

This study tested whether a supplement called nicotinamide mononucleotide (NMN) can improve how the body handles sugar in people with prediabetes. Researchers gave NMN to 56 adults with higher-than-normal blood sugar and measured changes in insulin sensitivity and glucose toleran…

This pilot study tested a program called 'Nudges to Quit' that sends encouraging messages to people with serious mental illness who smoke. The goal was to see if these messages could help them start smoking cessation treatments like counseling or medication. The study involved 59…

This study tested whether a drug called moxidectin, combined with other medicines, works better than the standard treatment (ivermectin combinations) for lymphatic filariasis, a parasitic disease that can cause severe swelling. 164 adults with the infection received a single dose…

This study tested two ways to help food-insecure adults with heart risks eat more fruits and vegetables. One group got a $20 grocery credit every two weeks, the other got a box of produce delivered to their home. Researchers measured changes in diet and food security over time.

This early-phase study tested a drug called adrabetadex (VTS-270) given through a vein to treat liver disease in infants with Niemann-Pick disease type C, a rare and fatal genetic disorder. Four babies up to 6 months old received multiple doses to see if the drug could lower abno…

This study tested a drug called ADI-PEG 20 combined with two chemotherapy drugs (gemcitabine and docetaxel) in 98 people with soft tissue sarcoma, osteosarcoma, Ewing's sarcoma, or small cell lung cancer. The goal was to see if the combination could slow cancer growth better than…

This phase 2 trial tested a combination of two drugs (retifanlimab and epacadostat) plus radiation and bevacizumab in 51 patients with recurrent glioblastoma, an aggressive brain cancer. The goal was to boost the immune system's attack on the tumor and improve survival. The study…

This phase 2 trial tested the chemotherapy drug mitomycin C in 48 patients with incurable head and neck cancer that had stopped responding to standard treatments. The goal was to see if the drug could shrink tumors. Researchers hope to find a new option for patients with very lim…

This study tested a lifestyle program called HEALTH, which teaches healthy eating and active living through home visits, to help overweight mothers prevent weight gain and lose weight. Over 600 participants took part in this Phase 3 trial. The program was delivered by trained par…

This study tested a new treatment approach for people with inoperable non-small cell lung cancer. It combined MRI-guided radiation therapy with chemotherapy and an immunotherapy drug called durvalumab. The goal was to see if this combination is safe and effective at controlling t…

This early-phase trial tested a combination of three drugs—cabozantinib, abiraterone, and nivolumab—in 18 men with metastatic hormone-sensitive prostate cancer that had not yet been treated. The main goal was to find a safe dose and check for serious side effects. Researchers als…

This study tested a shorter course of pelvic radiation (about 1 week instead of the usual 5-6 weeks) given after hysterectomy for advanced endometrial cancer. The goal was to see if this shorter treatment causes fewer side effects while still controlling the cancer. The study inc…

This completed Phase 4 trial tested whether adding efavirenz (a standard HIV drug) to a person's usual combination therapy could reduce the size of the hidden HIV reservoir. Seven adults with well-controlled HIV took one extra pill daily for six months. Researchers measured safet…

This phase 1 trial tested a new radioactive imaging agent called 64Cu-DOTA-ECL1i to see if it can detect a protein called CCR2 in pancreatic tumors using PET scans. The study involved 69 adults with pancreatic ductal adenocarcinoma at various stages. The goal was to see if the sc…

This early-phase study tested a new radioactive tracer called Ga-68 Galmydar for PET scans of the heart. The goal was to see if it can accurately show blood flow to the heart muscle in people with or without coronary artery disease. Fifteen adults received the tracer and underwen…

This study tested a new imaging method that combines ultrasound with light to better tell if a breast lump is cancer or not. The goal was to see if this approach could safely reduce the number of women who need a needle biopsy for a benign (non-cancerous) lump. About 298 women wi…

This study looked at whether proteins in spinal fluid can help doctors tell the difference between multiple sclerosis (MS) and other brain diseases, and also predict how MS will progress. Researchers analyzed spinal fluid samples from 161 people with MS using a special test calle…

This study tested a program that screens newborns for risk of child maltreatment using birth record data. Families identified as higher risk were randomly offered personalized guidance to connect them with community support services like home visits and parenting education. Resea…

This study tested whether combining personal hygiene (using medicated washes and ointments) with household cleaning can prevent MRSA skin infections. Over 800 people from households with a recent MRSA infection took part. The goal was to see if this combined approach reduces the …

This study tested a program called ANZANSI to help teenage girls in low-income countries stay in school and avoid moving to cities for work. About 200 girls aged 11 to 14 who were skipping school took part, along with their caregivers. The program aimed to change their intentions…

This study tested whether giving a low-dose ketamine drip after surgery could prevent depressive symptoms in 32 neurosurgical patients who had a history of depression. Researchers measured depression scores before surgery and for two weeks after. The main goal was to see if a lar…

This study tested a community-based campaign to increase HPV prevention among 350 mother-daughter pairs in Nigeria. The goal was to get more girls ages 9-14 vaccinated against HPV and more mothers ages 30-65 to do a simple self-test for HPV. The campaign used crowdsourcing to fin…

This study tested whether a program designed specifically for women who use drugs could help them reduce their risk of HIV and other sexually transmitted diseases. 501 women were randomly assigned to receive either standard counseling, standard counseling plus a well-woman exam, …

This study tested different strategies to increase RSV vaccination among 50 pregnant people. The goal was to find the best way to encourage vaccination at the right time during pregnancy to protect newborns from severe RSV. The study compared early and late vaccination timing alo…

This study tested whether teaching financial skills and providing economic support could reduce alcohol and drug use among teens and young adults living with HIV in poor areas of Uganda. Researchers enrolled 95 participants aged 15-24 who were already in HIV care and had used alc…

This study tested a 12-week program called SSAGE that brings together adolescent girls, their brothers, and their parents to discuss gender roles, communication, and healthy relationships. The goal was to prevent anxiety, depression, and other mental health issues in girls who we…

This study tested whether removing home hazards—like loose rugs or poor lighting—can reduce falls in older adults living in low-income senior apartments. Over 500 residents took part. Researchers tracked how many enrolled, how well the program was delivered, and how many falls oc…

This completed trial tested whether fluvoxamine, an FDA-approved drug for OCD, can improve long COVID symptoms like trouble concentrating, anxiety, depression, and fatigue. 191 adults from Missouri and Illinois who had COVID at least 3 months earlier took either fluvoxamine or a …

This study looked at whether adding nonsteroidal anti-inflammatory drugs (NSAIDs) to standard pain relief is safe for women with severe preeclampsia after giving birth. 287 women participated, and researchers measured their blood pressure and need for blood pressure medication. T…

This pilot study tested a web-based program called OptimalWork that teaches cognitive behavioral therapy (CBT) skills to help medical trainees manage stress, anxiety, burnout, and depression. 35 participants were randomly assigned to either the 4-week online course or a podcast-l…

This study tested a problem-solving therapy program for family caregivers of people with cancer who were receiving palliative care. Over 500 caregivers took part to see if the therapy could reduce their anxiety and depression. The goal was to improve caregivers' emotional well-be…

This study developed and tested a mobile app with coaching and a social network for adults with anorexia nervosa who recently left intensive treatment. The goal was to see if the app could help reduce eating disorder symptoms compared to usual care. 90 women participated, and the…

This early study tested whether a carefully controlled dose of propofol, a common anesthetic, could safely boost brain slow waves in 16 older adults with treatment-resistant depression. Participants received two propofol infusions days apart while researchers monitored brain acti…

This study tested two pain relief methods after total knee replacement. One group received a nerve block plus an injection around the knee, while the other group received only the injection. The goal was to see which approach better reduces pain and the need for opioid painkiller…

This study tested whether a program combining behavioral activation (helping people do meaningful activities) and medication optimization (adjusting meds) can reduce depression and anxiety in adults 60 and older undergoing heart surgery. 105 participants were split into two group…

This study tested a program that combines counseling (behavioral activation) with medication adjustments to reduce depression and anxiety in adults aged 60 and older who were scheduled for hip or knee replacement surgery. 116 participants were randomly assigned to receive the pro…

This pilot study tested whether giving two medications (mifepristone and misoprostol) at the same time helps women deliver faster after a nonviable second-trimester pregnancy, compared to misoprostol alone. Thirty women between 14 and 28 weeks pregnant who needed labor induction …

This study tested two rhythm-based walking exercises in 74 people with mild-to-moderate Parkinson's disease. Participants walked to music or while singing for 12 weeks. Researchers measured walking speed and brain activity to see which method worked better.

This study tested whether a program that combines behavioral activation (a type of counseling that helps people engage in meaningful activities) with medication optimization (reviewing and adjusting current medications) can reduce anxiety and depression in adults aged 60 and olde…

This pilot study tested a new way to deliver radiation therapy to people with recurrent IDH-mutant gliomas who had already received radiation to the brain. Instead of giving one large dose, the radiation was given in many small, timed pulses to reduce side effects. The study incl…

This study tested two programs to reduce the shame and stigma that adolescents with HIV often face. 89 teens aged 10-14 in Uganda took part in either group therapy, family sessions, or standard care. The goal was to see if these programs could help them feel better about themselv…

This study looked at whether a cochlear implant in the poorer ear can help adults with hearing loss in one ear who already use a hearing aid in the better ear. Forty adults who had trouble with standard hearing aids received a cochlear implant. Researchers measured word understan…

This study looked at whether a cochlear implant in the deaf ear helps adults who have good hearing in one ear but severe hearing loss in the other. 59 adults received an implant and were tested on understanding speech in quiet and noise, locating sounds, and overall benefit. The …

This study tested a mobile app designed to help teens with eating disorders who are not currently in treatment. Researchers recruited 161 teens through Instagram and Facebook. Participants used a guided self-help app, with some also getting coaching or a social networking feature…

This early-phase study tested whether TUDCA, a bile acid supplement, is safe and can reduce stress in gut cells of people with active ulcerative colitis. Fourteen adults took TUDCA for 6 weeks while researchers measured changes in cell stress markers from colon biopsies. The goal…

This study tested a program called PEEPS for people with endometriosis-related pelvic pain. Over eight weekly sessions, participants learned about mindfulness, yoga, nutrition, and pain coping strategies, while getting support from peers and clinicians. The goal was to see if the…

This study tested whether placing a cold tube in the vagina for 10 minutes can reduce pelvic floor muscle pain in women. 165 women with pelvic pain used either a cold or room-temperature tube. Researchers measured pain changes right after use and after two weeks of daily use.

This study tested a customized mental health app called Wysa in 30 adults with chronic neck or back pain who also had anxiety or depression. The app uses an AI chatbot and human coaches to deliver therapy and mindfulness tools. Participants used the app for one month, and researc…

This study looked at 123 people who had knee replacement surgery using the MAKO robot. Researchers tracked their pain, steps, and motion with a Fitbit and knee brace to see if robotic help leads to faster recovery compared to traditional surgery. The goal is to find out if the ro…

This pilot study tested whether a stellate ganglion block—a numbing injection near a nerve cluster in the neck—can help people who lost their sense of smell after COVID-19. Twenty adults with smell problems lasting at least a year received the injection. Researchers measured chan…

This study tested whether weekly improvisational dance classes could improve thinking and daily function in people with Parkinson's disease. Twenty participants were randomly assigned to either take the 12-week dance class or continue their usual routine. Researchers measured cha…

This study tested two non-drug treatments for paradoxical vocal fold motion (PVFM), a condition where vocal cords close when they should open, causing shortness of breath. Fifty-one adults were randomly assigned to either biofeedback (watching their breathing on a screen) or lary…

This study tested whether combining a low-intensity mental health program (Self Help Plus) with cash payments of $300 could reduce stress and depression in 40 Afghan refugee women in Türkiye. Participants were randomly assigned to receive both at once or cash first with a delayed…

This study tested a device that gently vibrates the left ear to stimulate the vagus nerve, aiming to reduce the bother of chronic tinnitus. Forty adults with moderate to severe tinnitus used either the active device or a sham (inactive) device during 8 weeks of online mindfulness…

This study tested whether a stellate ganglion block (an injection near nerves in the neck) can improve distorted sense of smell (parosmia) caused by COVID-19. 48 adults with long-term smell issues after COVID took part. Half received the nerve block, half got a placebo (saline). …

This study looked at the best way to test for COVID-19 in K-12 schools serving underserved communities. Researchers compared two strategies: testing only people with symptoms versus weekly testing of everyone plus symptom testing. The goal was to see which approach reduced COVID-…

This pilot study tested whether it's possible to adjust proton radiation plans each day while the patient is on the treatment table. Ten adults with solid tumors took part. The goal was to see if this approach is safe and practical enough to study in a larger trial.

This study tested whether a gentle electrical current applied to the scalp can improve attention and change brain activity in healthy adults aged 18 to 45. Seventeen participants had their brain waves recorded while they rested or performed computer tasks, both with real and fake…

This pilot study explored whether combining lifestyle changes, risk factor management, medications, and supplements could improve movement, thinking, and immune function in aging adults. 23 sedentary adults aged 50-70 took part. The main goal was to see if the study methods were …

This study tested whether playing short sound bursts in sync with brain slow waves during sedation with dexmedetomidine can enhance sleep-like brain activity. 18 healthy adults each experienced in-phase, anti-phase, and sham stimulation in repeated blocks. The goal was to see if …

This study tested a program called DRAUP in two intensive care units to help doctors and nurses stop ordering chest X-rays after placing a central line with ultrasound guidance. The program included training, feedback, and support to change habits. Researchers studied 101 healthc…

This completed study looked at how regular cannabis use affects brain health and thinking skills in people with HIV and those without. Researchers used brain scans, blood and spinal fluid tests, and thinking tasks to compare 276 participants. The goal was to understand the combin…

This study tested whether changing the pitch and loudness settings on a cochlear implant (CI) could help people with single-sided deafness hear speech better in noisy places like restaurants. Researchers adjusted the CI programs of 45 adults to reduce the mismatch between the imp…

This study tested whether a special type of MRI (called DBSI) can predict how well people recover after surgery for a compressed spinal cord. 71 patients with cervical spondylotic myelopathy had this MRI before surgery and again 2 years later. Researchers looked for imaging marke…

This study looked at the best ways to encourage COVID-19 testing for children with intellectual and developmental disabilities and their teachers. Over 1,100 participants from two special school districts took part. The goal was to find what messages and strategies work best to k…

This completed early-phase study looked at how healthy adults respond to the rabies vaccine when given alone or with an immune-boosting shot (rabies immune globulin). Thirty participants received different combinations of vaccine and immune globulin to compare antibody levels ove…

This study looked at how tough early life experiences might change how children feel pain and later develop emotional or behavioral problems. Thirty-nine kids from a larger study dipped their hand in cold water, once alone and once holding their parent's hand. Researchers measure…

This study tested a simple hearing screening for head and neck cancer survivors who had chemotherapy and radiation. 55 adults completed a hearing questionnaire and a quick hearing test. The goal was to see if the screening was practical and helpful for catching hearing problems e…

This study looked at how puberty affects pain sensitivity in 36 healthy adolescents aged 9-16. Researchers measured pain responses to heat and cold, and checked sex hormone levels. The goal was to understand if early or mid-puberty changes pain perception and who might develop ch…

This small study looked at how a class of diabetes drugs called SGLT2 inhibitors might reduce inflammation linked to heart and kidney disease. Six healthy adults took the medication for three days, and researchers measured changes in blood markers of inflammation. The goal was to…

This study looked at whether repairing the subscapularis tendon during reverse shoulder replacement surgery leads to better short-term outcomes. A total of 102 adults having primary reverse shoulder arthroplasty took part. Half had the tendon repaired, half did not. The goal was …

This study looked at whether people who inject opioids can safely finish a course of IV antibiotics at home instead of staying in the hospital. Ten participants received home antibiotic therapy along with addiction medication and support from a health coach and case manager. The …

This study looked at whether viral infections and diabetes in pregnant women are linked to congenital heart defects in their babies. Researchers analyzed blood and stool samples from 114 women to detect viruses and immune responses. The goal was to gather knowledge for future lar…

This completed study looked at 175 people with both coronary heart disease and depression. Researchers measured depression severity and heart risk markers to understand which symptoms, like fatigue and loss of interest, might be linked to worse heart outcomes. The goal is to find…

This study looked at why pregnant women tend to get more severe flu but not worse COVID-19. Researchers collected nasal brush samples and blood from 48 pregnant and non-pregnant women to compare how their immune systems respond to these viruses. The goal is to understand the prot…

This study used a special brain imaging technique called HD-DOT to see how deep brain stimulation (DBS) changes brain network activity in 49 people with Parkinson's disease. Researchers compared scans with DBS turned on and off, while participants did motor and cognitive tests. T…

This study followed 2500 adults having major surgery to see if we can predict who will develop persistent pain 3 to 6 months later. Researchers collected information on patients' history, physical and mental health, and daily experiences using smartphone surveys. The goal is to f…

This study looked at whether sleeping longer can improve how the body processes sugar in people with obesity. About 30 participants who slept less than 7 hours a night were split into two groups: one tried to sleep more, the other kept their usual habits. Researchers measured cha…

This study used advanced brain scans to see how psilocybin, the active ingredient in magic mushrooms, affects brain networks. Eleven healthy adults who had used psychedelics before but not recently took part. The goal was to understand the brain changes that might explain psilocy…

This study tested whether a mild electrical pulse on the ear (vagus nerve stimulation) can reduce inflammation after a stroke. Forty adults with a recent stroke received either standard care or standard care plus the ear stimulation. Researchers measured changes in blood markers …

This study tested a toolkit to help rural clinics in Southern Illinois get more people to complete a colonoscopy after a positive stool test. Over 185,000 patients were involved. The goal was to see if patient education and provider support could improve follow-up rates and reduc…

This study looked at how the brain adapts when people have a nerve injury in their dominant arm. Researchers used brain scans to see which parts of the brain help people move skillfully with their left, non-dominant hand. The study included 120 adults, some with a chronic nerve i…

This completed study surveyed over 2000 healthy adults from different racial and ethnic groups to see if watching an educational video about epigenetics improves their knowledge and acceptance of using this science in medicine. Participants watched either an epigenetics video or …

This study looked at whether certain proteins in the blood can predict if the drug vedolizumab (Entyvio) will reduce inflammation in the small bowel of people with Crohn's disease. Researchers used MRI scans to measure changes in the bowel wall after treatment. The goal is to hel…

This study tested whether a device that measures muscle vibrations (mechanomyography) during surgery can predict recovery in 23 patients with cubital tunnel syndrome or peroneal nerve entrapment. Researchers tracked patient-reported outcomes and disability scores after nerve deco…

This pilot study tested whether a tailored program could help older adults (65+) who take multiple prescription medications and have trouble sticking to their schedule. Four participants received home visits from occupational therapy students who gave personalized tips and low-co…