Custom-Made vaccine targets pancreatic cancer in early human test
NCT ID NCT05111353
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 1 trial tested a personalized vaccine made from each patient's unique cancer mutations (neoantigens) combined with an immune booster (poly-ICLC) in 33 people with pancreatic cancer. The vaccine was given after standard chemotherapy, either before or after surgery. The main goal was to check safety and see if the vaccine could trigger an immune response against the cancer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- personalized neoantigen synthetic long peptide vaccine plus poly-ICLC (Hiltonol)
- What this could lead to
- If successful, this could pave the way for a new personalized vaccine approach to help the immune system fight pancreatic cancer after standard chemotherapy.
- What could go wrong
- This is a very early phase 1 trial with only 33 participants, so safety and immune response are the main goals—not yet proof of effectiveness. The vaccine is custom-made for each patient, which limits scalability and may not work for everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Washington University School of Medicine
St Louis, Missouri, 63110, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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