Bile acid supplement shows promise for gut inflammation in early trial

NCT ID NCT04114292

First seen Mar 11, 2026 · Last updated May 12, 2026 · Updated 9 times

Summary

This early-phase study tested whether TUDCA, a natural bile acid, is safe and can reduce stress in gut cells of people with active ulcerative colitis. Fourteen adults took TUDCA for 6 weeks while researchers monitored side effects and measured changes in cell stress markers from colon biopsies. The goal was to see if TUDCA could help control disease, not cure it.

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Contacts and locations

Locations

  • Barnes-Jewish Hospital

    St Louis, Missouri, 63110, United States

  • Barnes-Jewish West County Hospital

    Creve Coeur, Missouri, 63141, United States

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.