Depression and heart disease: new study seeks clues to improve survival

NCT ID NCT04682769

Completed Knowledge-focused Sponsor: Washington University School of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study looked at 175 people with both coronary heart disease and depression. Researchers measured depression severity and heart risk markers to understand which symptoms, like fatigue and loss of interest, might be linked to worse heart outcomes. The goal is to find better targets for treatment to improve both mood and survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could point toward better ways to treat depression in heart patients, potentially improving survival.
What could go wrong: This is an observational study, not a treatment trial. It may not lead to direct benefits, and findings may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder Coronary Disease Depression depressive disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORONARY HEART DISEASE DEPRESSION

Contacts and locations

Locations

Washington University

St Louis, Missouri, 63108, United States

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