Ketamine plus talk therapy: a new hope for stubborn depression?
NCT ID NCT06138691
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This small pilot study tested whether combining intravenous ketamine with a specific talk therapy called RO DBT is safe and feasible for adults with treatment-resistant depression. Sixteen participants received four weekly ketamine infusions plus four months of RO DBT. The main goal was to see if the combination is practical and safe, and to measure changes in depressive symptoms.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ketamine infusion plus radically open dialectical behavior therapy (RO DBT)
What this could lead to
If this combination proves safe and feasible, it could point toward a new treatment approach for people with depression that hasn't responded to other therapies.
What could go wrong
This is a very small, early-phase study with only 16 participants. It focuses on safety and feasibility, not on proving the treatment works. Ketamine can cause side effects like dissociation or nausea.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Washington University School of Medicine
St Louis, Missouri, 63110-1010, United States