Washington University School Of Medicine

This study is testing a less intense stem cell transplant procedure for children and young adults with inherited disorders like sickle cell disease and metabolic conditions. The goal is to replace a patient's faulty blood-forming system with a healthy donor's cells while reducing…

This study is testing whether a combination of targeted radiation and an immunotherapy drug (pembrolizumab) can help prevent mucosal melanoma from returning after it has been surgically removed. The treatment is for adults with mucosal melanoma of the head and neck who have had s…

This early-stage study is testing whether a drug called NT-I7 can make CAR-T cell therapy work better for people with large B-cell lymphoma that has come back or hasn't responded to treatment. Researchers want to see if giving NT-I7 after standard CAR-T therapy is safe and if it …

This early-stage trial is testing a new CAR-T cell therapy called WS-CART-CS1 for people with multiple myeloma that has returned or stopped responding to at least three previous treatments. The study aims to find the safest dose and see if this therapy, which targets a protein ca…

This study is testing an experimental drug called CUE-101, given before standard surgery or chemoradiation, for people with a specific type of HPV-linked throat cancer. The main goals are to check if the drug is safe and to see if it activates the patient's immune system to bette…

This early-stage study is testing the safety of a new combination treatment for people with advanced melanoma that has continued to grow despite standard immunotherapy. The treatment involves infusing specially prepared 'memory-like' natural killer (NK) immune cells, either from …

This study is testing whether a 14-week supervised exercise program at an accessible community gym can improve heart health, body composition, and fitness for adults who use wheelchairs. Researchers will compare this structured workout group to a group that just receives educatio…

This early-stage study is testing a new drug, zanzalintinib, combined with a standard chemotherapy (paclitaxel) for people with recurrent high-grade uterine or endometrial cancer that has worsened after prior treatment. The main goal is to find the safest and most effective dose …

This study is testing whether adding a structured weight loss program to standard hormone therapy helps premenopausal women with obesity reverse early-stage uterine cancer or pre-cancer. The goal is to help women avoid a hysterectomy and preserve their fertility by treating the u…

This pilot study is testing a 3-month personalized program to see if it can improve physical, mental, and immune health in older adults. The program combines lifestyle changes like exercise and diet with specific medications and supplements. Researchers will enroll about 20 seden…

This study is testing whether freezing small breast tumors (cryoablation) works as well as standard surgery (lumpectomy) for early-stage breast cancer. Researchers will compare both treatments in 120 women aged 50+ with low-risk tumors to see which has fewer complications, better…

This study is testing a new digital tool called PREVENT, designed to help doctors in rural clinics provide better diet and exercise counseling to patients with obesity. The tool displays patient health information to guide conversations and set personalized goals. Researchers wil…

This study is testing a custom mouthpiece for adults with severe obstructive sleep apnea who couldn't use a CPAP machine and also didn't get enough benefit from an implanted nerve stimulator. Researchers want to see if this mouthpiece is safe, practical, and effective at reducing…

This early-stage study is testing whether adding one or two drugs to standard treatment can better prevent two serious complications that can occur after a half-matched stem cell transplant for blood cancers. The complications are graft-versus-host disease (where donor cells atta…

This study compares two methods doctors use to check the cervix when a pregnant woman's water breaks too early (before 37 weeks). Researchers want to see if a gentle finger exam is as safe as the traditional speculum exam for keeping the pregnancy going longer and preventing infe…

This study aims to see if popular GLP-1 weight-loss medications, when taken with or without a supervised exercise program, help people with obesity keep their muscle mass and physical strength while losing weight. It will also look at what happens to muscle and metabolism when pe…

This is a small, early-stage study to see if a drug called dapagliflozin, normally used for diabetes, is safe and tolerable for men with aggressive prostate cancer before they have surgery to remove the prostate. Researchers want to see if taking the pill daily for four weeks bef…

This study is testing a training and support program for doctors and nurses at community health centers. The goal is to help them better use a specific, guideline-recommended asthma treatment plan called SMART. Researchers want to see if this program helps clinics adopt this trea…

This is an early-stage safety study for a new type of personalized cancer vaccine. It is for patients with bladder or stomach cancer who have had surgery but still have tiny traces of cancer DNA in their blood, putting them at high risk for the cancer coming back. The goal is to …

This study is testing if adding a nutrient called choline to the special food given to treat severe malnutrition helps children's brain development. Researchers in Malawi will give 1500 malnourished children, aged 6-59 months, either the standard therapeutic food or the food with…

This study is testing whether a new preparation method is safe for multiple myeloma patients with poor kidney function before they receive a CAR-T cell therapy called Carvykti. Standard preparation methods are not approved for these patients, creating an urgent need. The research…

This study is testing if taking a pill called selinexor after receiving CAR-T cell therapy can help keep multiple myeloma under control for longer. It is for patients whose cancer has come back after many treatments and who have high-risk features. The main goal is to see if addi…

This study is testing whether a new, precise radiation planning technique can protect the ovaries in young women (ages 18-50) receiving pelvic radiation for cancers like uterine or rectal cancer. The goal is to prevent radiation from causing early menopause, which can lead to ser…

This study is testing whether adding a common decongestant (oxymetazoline) to a standard steroid nasal spray works better than the steroid spray alone for adults with long-term nasal blockage that hasn't improved with usual care. About 80 participants will use one of the two spra…

This study is testing a modified stem cell transplant procedure to prevent lymphoma from spreading to the brain and spinal cord in high-risk patients. Researchers will enroll 36 adults with a specific type of aggressive lymphoma who have finished initial chemotherapy and are in r…

This study is testing whether a drug called enasidenib can safely help people with a condition called Clonal Cytopenia of Undetermined Significance (CCUS), which causes persistently low blood counts. Researchers think the drug might work by blocking a specific mutated protein fou…

This study compares two alternative treatments for moderate-to-severe obstructive sleep apnea in people who cannot use standard CPAP machines. Researchers will follow 60 patients who receive either a custom mouthpiece (MAD) or an implanted nerve stimulator (HGNS). The main goal i…

This study is testing if a gentle, non-invasive electrical stimulation of a nerve in the ear can help patients recover faster in the neurological intensive care unit (NeuroICU). It will involve 160 adults with serious brain or spinal cord injuries. Researchers will compare real s…

This study is testing a personalized approach to keep multiple myeloma under control after a stem cell transplant. It uses a sensitive blood test to detect tiny amounts of leftover cancer cells and guide treatment with a drug called elranatamab. The goal is to see if this tailore…

This study is testing whether adding a new drug called cirtuvivint to standard chemotherapy can better control small cell lung cancer that has returned after initial treatment. It will enroll about 42 adults whose cancer has progressed after prior platinum-based chemotherapy. The…

This early-stage study is testing whether adding the diabetes drug dapagliflozin to standard cancer treatment is safe for children and young adults with recurrent brain tumors or solid tumors that have come back or resisted treatment. The main goal is to check for side effects, b…

This study is testing whether a very-low-carbohydrate ketogenic diet can help adults with type 1 diabetes better control their blood sugar levels. For 12 weeks, participants will follow either the ketogenic diet or a standard diabetes diet to compare safety and effectiveness. Res…

This study is testing whether non-invasive electrical stimulation of the spinal cord can help people with spinal cord injuries regain better control of their leg movements. Researchers will adjust where, how often, and how strong the electrical pulses are to target specific muscl…

This study is testing three different higher doses of targeted radiation to see which works best for controlling early-stage prostate cancer while causing the fewest side effects. Researchers will enroll 36 men with early prostate cancer to receive one of the radiation doses and …

This early-stage study is testing a personalized DNA vaccine for children and young adults (ages 12-25) whose brain or spine tumors have returned or resisted treatment. The main goals are to see if creating and giving this custom vaccine is safe and possible. Researchers will als…

This study is testing if a drug called zanzalintinib can help keep aggressive neuroendocrine tumors from growing after patients finish their initial chemotherapy. It is for adults whose cancer has stopped growing or shrunk after chemo. The main goal is to see if this maintenance …

This study is testing a new computer system designed to help doctors decide which surgery patients need blood prepared in advance. It aims to ensure patients who need a transfusion can get one safely, while avoiding unnecessary preparation and waste for those who likely won't. Th…

This study is testing whether a low-dose anesthetic drug (propofol), given as an IV infusion, can help treat depression in adults aged 60 and older. The idea is that the drug may boost deep, restorative sleep, which is often disrupted in depression. All 70 participants will also …

This early-stage study is testing the safety and effectiveness of a new type of stem cell transplant for children with high-risk or returning blood cancers like leukemia. The procedure uses a partially matched family donor's cells that are specially processed to remove certain im…

This large study aims to determine if giving mothers extra oxygen during concerning fetal heart rate patterns actually helps babies or might cause harm. Researchers will compare oxygen to regular room air in over 2,000 women in labor at full term. The goal is to provide clear evi…

This study is testing a new approach for patients with myelodysplastic syndromes (MDS, a type of blood cancer) who have had a stem cell transplant. Researchers will use a sensitive blood test one month after transplant to check for tiny traces of leftover cancer. If found, patien…

This early-stage trial is testing whether adding a new experimental drug called zunsemetinib to a standard chemotherapy regimen (mFOLFIRINOX) is safe and tolerable for people with newly diagnosed metastatic pancreatic cancer. The main goal is to find the right dose of the new dru…

This study is testing whether dapagliflozin, a medication typically used for diabetes, can slow the progression of geographic atrophy, an advanced stage of age-related macular degeneration that causes vision loss. About 70 participants with this specific eye condition will take e…

This study is testing whether a nerve transfer surgery can help restore elbow movement and arm function in people with high-level spinal cord injuries in their neck. Researchers will observe 30 participants who undergo this standard surgical procedure, tracking their strength, in…

This early-stage trial is testing whether combining two drugs, zanzalintinib and eribulin, is safe and might help control advanced liposarcoma and leiomyosarcoma. It will enroll 18 adults whose cancer has worsened after at least one prior treatment. The main goal is to find the h…

This study is testing whether adding a special 3D collagen patch, called Miro3D, to standard wound care helps heal difficult wounds faster or better. It will involve about 70 adults with either serious acute wounds (like from surgery or infection) or chronic pressure sores that h…

This study is testing if a buprenorphine skin patch can help pregnant women with opioid addiction start treatment with less severe withdrawal symptoms. Normally, patients must go through withdrawal before beginning medication, but the patch may ease this difficult period. Researc…

This early-stage trial is testing whether adding a new medication called siltuximab to standard treatment is safe for lung transplant patients experiencing antibody-mediated rejection. The study will enroll 30 hospitalized adults who have recently been diagnosed with this type of…

This study is testing whether a simple blood test taken early in treatment can help doctors make better decisions for patients with advanced breast cancer. Patients will receive standard first-line treatment, then have their blood tested after two weeks. If the test shows the tre…

This study is testing if adding an experimental drug called epacadostat to the standard pre-surgery treatment (chemotherapy and radiation) works better for people with locally advanced rectal cancer. The main goals are to find the safest dose of the new combination and to see if …

This study is testing a personalized plan to help cancer patients quit smoking. It uses a patient's own genetic and health information to recommend the best quit-smoking medications. The goal is to see if this tailored approach helps more patients successfully quit and improves t…

This study is for people with advanced thyroid cancer that has stopped responding to standard radioactive iodine treatment. Researchers want to see if a lower daily dose of the drug lenvatinib (10 mg) works as well as the standard higher dose (24 mg) while causing fewer side effe…

This study is testing whether a daily drink containing ketone esters can help improve liver health and blood sugar control in adolescents with obesity and fatty liver disease (MASLD). For 6 weeks, 40 participants will be randomly assigned to drink either the ketone supplement or …

This study compares two training programs designed to help community health centers provide better weight management care to Medicaid patients. It will train doctors, dietitians, and other health workers at clinics across the country. The research will measure which training appr…

This study is testing a new immune cell therapy for children and young adults (up to age 40) with high-risk acute myeloid leukemia (AML). The goal is to see if giving specially prepared 'memory-like' natural killer (NK) cells from a partially matched family donor is safe and poss…

This study is testing whether exposure to a special bright blue light can help the body's immune system fight serious infections. It involves 144 adults hospitalized for conditions like pneumonia, severe abdominal infections, or infected joints. Participants are randomly assigned…

This study is testing if adding a special milk-derived ingredient (MFGM) to the standard therapeutic food given to children with severe malnutrition can improve their brain development and reduce the worst outcomes like death or hospitalization. Researchers in Sierra Leone will c…

This study is testing a new drug, zunsemetinib, combined with the standard chemotherapy capecitabine, for people with a specific type of advanced breast cancer that has spread to the bones. The main goals are to find a safe and effective dose and to see if the combination can hel…

This study aims to determine whether surgery or targeted radiation therapy is more effective for treating early-stage lung cancer. It will follow 444 patients who are eligible for either treatment, tracking their cancer recurrence, survival, and quality of life for up to three ye…

This study is testing whether changing the order and schedule of radiation treatment can improve outcomes for people with locally advanced cervical cancer. Researchers want to see if giving internal radiation first, followed by a shorter course of external radiation, can better c…

This study is testing two practical support strategies to help pregnant and postpartum people stay in substance use treatment. It will check if connecting people to community resources like housing or childcare, and offering small rewards for attending appointments, are helpful a…

This study tests whether personalized treatment recommendations based on a person's genetic and health information can help smokers quit more effectively than standard care. The research involves 850 adult smokers and their doctors across primary care clinics. It compares the new…

This is an early-stage study to test the safety of a new three-drug combination for people with advanced soft tissue sarcoma that has spread. The trial will enroll 18 patients to see if the drugs can be given together safely and to get an early look at whether the treatment helps…

This study is testing a method to help people who are dependent on over-the-counter nasal decongestant sprays. It aims to see if slowly reducing the decongestant spray while adding a prescription steroid spray can safely break the cycle of rebound congestion. The trial is conduct…

This study is comparing two different schedules of radiation therapy for breast cancer that has spread to the lymph nodes. It aims to see if a much shorter, 1-week treatment is as safe and effective as the current standard 3-week treatment. Researchers will measure side effects, …

This study is testing whether tofersen, a drug already approved for a specific genetic form of ALS, is safe and can lower a key disease marker in people with ALS who do not have that specific gene mutation. About 30 adults with early-stage ALS will receive the drug via spinal inj…

This early-stage trial is testing a new drug called CA-4948 in combination with standard chemotherapy and immunotherapy for people with advanced stomach or esophageal cancer that cannot be surgically removed. The study aims to find the safest dose of this combination and see if i…

This study is testing whether combining two drugs—polatuzumab vedotin and rituximab—is safe and effective for treating a type of lymphoma that can develop after an organ or stem cell transplant. The goal is to control the cancer while avoiding the severe side effects of tradition…

This study is testing two different support programs to help stroke survivors transition from hospital rehabilitation to living at home. Researchers want to see if these programs can help people avoid moving to nursing facilities and live more independently. The study will compar…

This trial is testing a new, less intense bone marrow transplant procedure for children and young adults with severe, non-cancerous blood disorders like sickle cell disease. The goal is to see if using a partially matched donor from the patient's own family is safe and can succes…

This study is testing whether a prescription sleep aid called lemborexant can reduce levels of proteins linked to Alzheimer's disease in the body. It will involve about 200 older adults who have early signs of Alzheimer's but no memory problems yet. Researchers will measure prote…

This study is testing if a non-invasive device that gently stimulates a nerve in the ear can help people recover from a major stroke. Researchers want to see if this stimulation can reduce harmful inflammation in the body and limit further brain injury after the initial stroke. T…

This early study is testing if adding an experimental drug called azeliragon to the standard initial treatment for glioblastoma (a type of brain cancer) can change the immune environment inside the tumor. Researchers want to see if it reduces certain immune-suppressing cells and …

This study aims to see if it's practical and acceptable to start hepatitis C treatment during pregnancy for women with a history of drug use. It will enroll 50 pregnant adults to receive a standard antiviral medication and track their adherence, completion rates, and experiences.…

This study is testing whether adding a new blood test called DiviTum® TKa to standard monitoring helps doctors make better decisions about when to schedule imaging scans for patients with advanced breast cancer. The goal is to see if this test can reduce the burden of frequent sc…

This study is testing a new 3D camera system called SkinScan3D to improve how doctors monitor Kaposi sarcoma skin tumors. The device takes detailed 3D pictures to measure tumor height and volume, which may detect treatment responses earlier than standard 2D photos. Researchers wi…

This study is testing a new type of imaging that combines ultrasound with light to get a better picture of the ovary. The goal is to see if this method can help doctors tell the difference between harmless growths and cancer more accurately. If successful, it could help many wome…

This study is testing if a special PET/MRI scan can better find the exact spot in the pancreas that is causing hyperinsulinism, a condition of dangerously low blood sugar. The scan is for patients whose medications have failed and who need surgery, which can be curative if the ri…

This study is testing a new imaging device that combines ultrasound and light to create detailed pictures of rectal tumors. The goal is to help doctors more accurately tell which patients have no cancer left after initial treatment and can safely avoid major surgery. About 90 pat…

This study is testing a new questionnaire for parents to help identify suicide risk in children aged 4-7. It will be used in a mental health clinic to see if it's practical and helpful for doctors and families. The goal is to catch warning signs early so children can get the righ…

This study is testing a new document called HPARSS that helps doctors quickly identify which childhood cancer survivors are at risk for hearing or vision problems due to their past treatments. Researchers will see if using this tool leads more survivors to get the right screening…

This study is testing a new noninvasive method called 'sonobiopsy' that uses focused ultrasound to help detect genetic markers from brain tumors in blood samples. Researchers want to see if this approach can provide detailed information about glioblastoma tumors without requiring…

This study is testing a new, wearable heart monitor patch to see if it works as well as standard hospital ECG machines. It aims to better track dangerous heart rhythms in 60 adults who are taking specific cancer medications known to affect the heart. The goal is to validate if th…

This study is testing whether a special campaign can help more women get screened for lung cancer. The campaign will run in mammography clinics, offering information and referrals to eligible women during their breast cancer screening appointments. Researchers will measure if the…

This study is testing investigational drugs to prevent Alzheimer's disease in people who carry a rare genetic mutation that almost guarantees they will develop the disease. It enrolls 280 participants who are currently healthy and have no symptoms, but are within a specific age w…

This study aims to find the best way to help people quit smoking to prevent cancer. It will compare two different support strategies for 5,000 current tobacco users. One strategy uses gentle reminders and nudges, while the other focuses on standard quit-focused care.

This study is testing if fluvoxamine, an existing medication, can prevent delirium (sudden, severe confusion) in older adults after non-heart, non-brain surgery. Researchers believe inflammation after surgery may cause delirium and that fluvoxamine might reduce this inflammation.…

This study is testing an investigational drug, remternetug, to see if it can prevent or slow the progression of Alzheimer's disease in people who carry a genetic mutation that causes the disease but do not yet have any symptoms. The trial will involve 280 participants who are 18 …

This study aims to find the best ways to help local community organizations in Nigeria continue offering HIV self-testing and prevention services to adolescents and young adults over time. It involves about 1,200 young people aged 14-24 who are at risk for HIV. Researchers are co…

This study is testing if providing a daily, nutrient-rich peanut paste meal at school helps children attend class more regularly and stay enrolled longer. It will compare this special meal to a common local porridge made from rice and millet. The goal is to see if better nutritio…

This study is testing whether a prescription sleep medication called suvorexant can slow down the buildup of a harmful protein in the brain that is linked to Alzheimer's disease. Researchers will enroll 200 healthy adults aged 65 and older who have normal memory. The main goal is…

This study aims to prevent a terrifying experience called 'awareness with paralysis,' where emergency room patients on breathing machines are awake but can't move. It will test if making a shorter-acting paralytic drug the standard choice reduces this risk and lowers rates of PTS…

This study is testing a support program to help young women in Uganda start and stick with a daily pill that prevents HIV. The program combines HIV education, peer mentors who have taken the pill themselves, and financial help like savings accounts. Researchers want to see if thi…

This study is testing a home safety program designed to prevent falls in adults with physical disabilities. Researchers will work with 80 participants to identify and remove tripping hazards in their homes. The goal is to see if making homes safer reduces the number of falls and …

This study is testing a campaign called 'Pink & Pearl' to see if it helps more women get screened for lung cancer. Researchers will offer information about lung cancer screening to women who are already getting a mammogram and are eligible based on their age and smoking history. …

This study is testing if a community-designed music video campaign can help prevent high blood pressure and stroke in Nigeria. Over 1,400 young people (ages 14-24) and their caregivers (age 40+) will attend three music listening sessions. Researchers will measure if the music hel…

This study is testing a smartphone app called Enhearten, designed to help pregnant women and new mothers who have a substance use disorder. The app aims to reduce feelings of shame and stigma, and to support them in sticking with their treatment plans. Researchers will compare ou…

This study is testing a wellness program designed for older Black patients who are scheduled for surgery and are feeling depressed or anxious. The main goal is to see if the program is practical to run and if patients find it helpful. Researchers will measure how many eligible pa…

This study is testing if a numbing injection (nerve block) given during facial fracture surgery can reduce the need for strong opioid painkillers right after the operation. It will involve 70 adults having surgery for a broken jaw or cheekbone. Participants will be randomly assig…

This early study is testing a specialized form of proton radiation called 'GRID' for patients with large, inoperable, or metastatic tumors that need treatment to relieve symptoms. The technique delivers radiation in a precise 'peaks and valleys' pattern, which researchers hope wi…

This small, early-stage study is testing if giving an anti-inflammatory drug (Ketorolac) *before* placing a ureteral stent can reduce the pain and urinary symptoms many patients experience afterward. The study will enroll 36 adults getting a stent for kidney stones. Researchers w…

This study is testing two different phone-based programs to see which one better helps people with HIV who also have chronic pain and insomnia. One program focuses on building better sleep habits, while the other teaches mindfulness techniques. Researchers want to see if these pr…

This study is testing a 16-week text message program designed to help people living with spinal cord injury manage common secondary health problems. The program sends information and support directly to participants' phones about bowel/bladder care, pain, pressure sores, and ment…

This study is testing whether a specific sequence of position changes guided by a nurse can help shorten the first stage of labor when it's taking too long. It will involve 82 pregnant people experiencing prolonged labor, comparing the new position circuit to standard care. Resea…

This study is testing whether an 8-week group support program helps women with chronic pelvic pain from endometriosis. It compares the group program, which includes yoga and peer support, to standard educational materials. Researchers want to see which approach better helps parti…

This study is creating a worldwide registry of people with Wolfram syndrome, a rare genetic disorder that causes childhood diabetes, vision loss, deafness, and other serious problems. Researchers will collect health information and blood/urine samples from up to 5,000 participant…

This study aims to understand why some healthy, normal-weight people develop high cholesterol when following a ketogenic diet. Researchers will identify 100 participants who show cholesterol increases after a 3-week keto diet, then measure how their bodies produce and remove chol…

This early study is testing whether an experimental oral drug called DSP-0390 can reach brain tumors in sufficient amounts and affect tumor cell metabolism. Researchers will give the drug for about two weeks to 20 patients with specific types of brain tumors (grade II/III gliomas…

This study is testing a new tool that uses an AI chatbot to create a personalized list of questions for patients with lymphoma or multiple myeloma to ask during their doctor's appointments. Researchers want to see if this helps patients feel more confident talking to their doctor…

This study aims to find out if continuing the labor medication oxytocin during the pushing stage is helpful or unnecessary. It will involve 400 first-time mothers in labor. Researchers will randomly assign some to continue the medication and others to stop it, then compare how lo…

This study aims to understand how electroconvulsive therapy (ECT) helps people with severe depression that hasn't responded to medications. Researchers will measure how ECT affects brain network connections and sleep patterns in 50 participants receiving treatment. The goal is to…

This study aims to understand how children with juvenile arthritis experience pain differently than healthy children. Researchers will measure pain sensitivity using pressure and cold tests and collect information about health and lifestyle. The goal is to learn more about the pa…

This study aims to understand how the body's immune system responds to two different FDA-approved flu vaccines: a standard shot and a nasal spray. Researchers will measure immune cells and antibodies in the blood, nose, and lungs of 30 healthy adults aged 18-40. Some participants…

This study aims to understand how blood flow and oxygen delivery affect brain development in children and young adults with sickle cell anemia. Researchers will use MRI scans and a special breathing test to measure how well blood vessels in the brain can expand when needed. The g…

This study is testing whether an animated educational video helps breast cancer patients better understand DIEP flap reconstruction surgery and reduces their anxiety. Researchers will survey 300 patients before and after they watch the video at their pre-surgery appointment, then…

This study aims to understand how being overweight and having blood sugar problems might affect brain development in teenagers. Researchers will follow 117 teens aged 12-17 for nearly two years, comparing brain scans and thinking tests across three groups: normal weight, overweig…

This long-term study aims to identify biological markers that can predict the future development of Alzheimer's disease in people who carry a specific genetic mutation for it. It observes 700 adult children of parents with inherited Alzheimer's, tracking changes in their brain sc…

This study is testing a blood test that looks for tiny pieces of tumor DNA to see if it can detect cancer recurrence earlier than standard scans. It aims to enroll 100 adults, including people with various solid tumors and healthy volunteers. The goal is to gather information tha…

This study is testing a new family communication tool called 'Let's Get REAL' to help children and teenagers be more involved in decisions about their stem cell or cellular therapy treatments. Researchers will work with 24 young patients (ages 8-17) and their parents to see if th…

This study uses brain scans to investigate a recently discovered brain system called SCAN, which researchers believe may be a key area affected in Parkinson's disease. The research involves 120 participants, including people with Parkinson's and healthy volunteers, who will under…

This study aims to see if measuring certain proteins in a person's blood can accurately predict who will develop Alzheimer's disease or experience cognitive decline. Researchers will follow 1,800 adults aged 60 and older, some with memory concerns and some without, for several ye…

This study aims to learn if a new type of PET-MR scan can better identify which patients with narrowed neck arteries are at highest risk for a future stroke. Researchers will scan 80 adults who have this narrowing but no current symptoms. The goal is to see if the scan results ca…

This study aims to understand how radiation therapy for brain tumors affects patients' thinking and memory skills. Researchers will use special brain scans and memory tests before and after treatment to identify which brain networks are most vulnerable to radiation damage. The fi…

This study is testing a new type of PET scan that uses a special radioactive tracer to look for inflammation in the brain. Researchers want to see if this tracer shows more inflammation in people with Multiple Sclerosis compared to healthy adults. The main goal is to learn if thi…

This study is creating a worldwide database to collect detailed information about a rare and aggressive type of nerve cancer called Malignant Peripheral Nerve Sheath Tumor (MPNST). It aims to gather past and future patient data, including tumor samples and treatment history, to u…

This study is testing a new digital tool called the Cancer Care Companion. It's designed to help parents of children recently diagnosed with cancer communicate better with their medical team and manage their child's care. Researchers want to see if parents find the tool easy to u…

This study is testing a new, detailed genetic test called ChromoSeq for patients with blood cancers AML or MDS. Researchers want to see if this test, which looks at a person's entire genetic code, finds more cancer-related changes than current standard tests. They will enroll 325…

This is an early, first-in-human study to test a new radioactive tracer used in PET/CT scans. The goal is to see if this tracer can safely and effectively highlight specific activity in the walls of abdominal aortic aneurysms (AAAs). Researchers will compare scans from healthy vo…

This study aims to understand why some inflammation continues in people with Multiple Sclerosis (MS) even after they start strong treatments. Researchers will use advanced brain scans and spinal fluid analysis on 25 adults with MS to identify the specific types of inflammation th…

This study aims to understand how blood flow and oxygen use in the brain affect its development in children and young adults. Researchers will use MRI scans on 350 participants, including healthy kids and those with conditions like sickle cell disease, to see how the brain's bloo…

This study aims to understand how brain tumors and their treatments affect children's thinking skills over time. Researchers will use special brain scans and thinking tests on children and young adults aged 4-30 who have been diagnosed with a brain tumor. The goal is to find earl…

This study is testing a new, more detailed genetic test called ChromoSeq to see if it works as well as the standard genetic tests used for patients with myelodysplastic syndromes (MDS), a type of blood and bone marrow disorder. Researchers will enroll 60 adults with MDS to compar…

This study aims to learn how radiation therapy changes the environment inside and around tumors in cervical and pancreatic cancer. Researchers will collect tissue samples, blood, and imaging data from 60 patients before, during, and after their standard radiation and chemotherapy…

This study aims to understand why some breast cancer cells survive chemotherapy and how they might cause the cancer to return. Researchers will compare genetic markers on cancer cells found in the bone marrow and blood before and after treatment in 300 patients. The goal is to id…

This study aims to find better, more objective ways to measure chronic muscle pain. Researchers will use MRI and other imaging techniques on adults with neck and shoulder pain to see if these scans can detect physical signs of pain and track how it changes after a standard treatm…

This study aims to understand if the types of bacteria in a person's gut are linked to the severity and recovery from Complex Regional Pain Syndrome (CRPS), a chronic pain condition. Researchers will collect stool samples from 140 adults with CRPS and their cohabiting partners to…