AI-Guided radiation may shield ovaries in young cancer patients

NCT ID NCT06904365

Ongoing Knowledge-focused Sponsor: Washington University School of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 17, 2026 · Updated 5 times

Summary

This study tests whether a new type of adaptive radiotherapy can reduce radiation exposure to the ovaries in young women (ages 18-50) receiving pelvic radiation for cancers like uterine, rectal, or cervical cancer. Using advanced imaging and an AI treatment planning system, researchers will simulate treatments on 10 patients to see if they can keep ovarian radiation doses low without compromising cancer treatment. This is a computer-based feasibility trial, not a treatment study, so it aims to gather knowledge for future research.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: HyperSight CBCT scan and ETHOS 2.0 AI treatment planning system
What this could lead to: If successful, this could show that adaptive radiotherapy is a feasible way to protect ovarian function in young women needing pelvic radiation.
What could go wrong: This is a very small, early feasibility study using computer simulations, not actual patient treatment. It may not translate to real-world benefits or work for all cancer types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

anal carcinoma anus neoplasm breast cancer breast neoplasm cervical carcinoma colon carcinoma colonic neoplasm female reproductive organ cancer gastric cancer gastric neoplasm head and neck cancer Head and Neck Neoplasms liver cancer Liver Neoplasms lung cancer lung neoplasm rectal cancer rectal neoplasm sarcoma urinary bladder carcinoma Urinary Bladder Neoplasms uterine cancer Uterine Cervical Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANAL CANCER BLADDER CANCER BREAST CANCER CERVIX CANCER COLON CANCER GASTRIC CANCER HEAD AND NECK CANCER LIVER CANCER LUNG CANCER RECTAL CANCER SARCOMA UTERINE CANCER

Contacts and locations

Locations

Washington University School of Medicine

St Louis, Missouri, 63110, United States

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