UTERINE CANCER

This study is testing a specialized type of radiation therapy called proton beam radiation for women who have had surgery for cervical or uterine cancer. The main goal is to see how often this treatment causes serious stomach and bowel side effects. Researchers will also track wh…

This study is testing whether the oral drug belzutifan can help control recurrent clear cell cancers of the ovary, uterus, cervix, and other gynecologic sites. It will enroll 32 adults who have already received platinum-based chemotherapy. Researchers will measure how well the dr…

This early-stage study is testing a new drug, zanzalintinib, combined with a standard chemotherapy (paclitaxel) for people with recurrent high-grade uterine or endometrial cancer that has worsened after prior treatment. The main goal is to find the safest and most effective dose …

This study is testing whether using MRI scans instead of CT scans to guide radiation therapy for gynecologic cancers can reduce side effects and improve treatment accuracy. Researchers at Johns Hopkins will compare how well MRI helps doctors target tumors while sparing healthy or…

This study is testing whether a new, precise radiation planning technique can protect the ovaries in young women (ages 18-50) receiving pelvic radiation for cancers like uterine or rectal cancer. The goal is to prevent radiation from causing early menopause, which can lead to ser…

This study is testing a new drug called Rina-S in people whose solid tumor cancers have spread or cannot be removed by surgery. The main goals are to find a safe dose and see if the drug can shrink tumors. It is for people with several types of advanced cancer, including ovarian,…

This study aims to develop a new, non-invasive test to help rule out uterine cancer in women aged 45 and older who have abnormal or postmenopausal bleeding. It will enroll 4,500 participants to see how accurately the test can detect cancer and identify non-cancerous cases. The go…

This study is testing whether transferring healthy gut bacteria from a donor (fecal microbiota transplantation) can help reduce severe diarrhea and colon inflammation caused by cancer immunotherapy drugs. The trial will enroll 40 patients with various cancers who developed these …

This study is testing whether two types of medical images—MRI and ultrasound—can be successfully combined to create a more precise 3D map for guiding radiation treatment (brachytherapy) in patients with uterine cancer. The goal is to see if this fusion technique is feasible and c…

This study aims to create a library of blood samples from cancer patients and people at high risk for cancer. Researchers will collect these 'liquid biopsies' to help future studies develop better ways to detect cancer early and monitor treatment. The study involves 2,500 partici…

This study aims to test a new method for collecting fluid from the uterus during gynecologic surgery. Researchers will analyze the cells and molecules in this fluid from 50 participants to better understand uterine health and disease. The goal is to gather knowledge, not to provi…

This study aims to collect blood and tissue samples from people with various cancers to help develop better blood tests. Researchers want to see if these tests can detect tiny amounts of leftover cancer cells after treatment, which might help predict if the cancer could return. P…

This study aims to understand how the experimental drug azenosertib affects cancer cells in women whose uterine serous carcinoma has returned or persisted after treatment. Researchers will enroll about 25 participants to take the drug and closely analyze tumor samples before and …

This study aims to see if changes in what people buy—like pain relief or digestive aids—can serve as an early warning sign for certain cancers. Researchers will compare the shopping history of 1,450 recently diagnosed cancer patients with 1,450 people without cancer, using up to …