UTERINE CANCER

This study tests a new drug called Rina-S in people with advanced solid tumors that have spread or can't be removed by surgery. The goal is to see if Rina-S is safe and how well it works against cancers like ovarian, lung, and breast cancer. About 764 participants will receive th…

This study tests a combination of two drugs, cabozantinib and dostarlimab, in 37 women whose gynecologic carcinosarcoma has returned after at least one prior chemotherapy. The goal is to see if the combination can keep the cancer from growing for at least 6 months. Participants w…

This study tests whether the drug belzutifan can shrink or control certain gynecologic cancers (like ovarian, endometrial, cervical, vaginal, or vulvar) that have come back or not gone away. About 32 adults with clear cell carcinoma will receive belzutifan pills. The main goal is…

This study tests a drug called azenosertib in 25 women whose uterine serous carcinoma has come back or not gone away. The drug blocks a protein (Wee1) that cancer cells need to grow. Researchers will check if the drug slows tumor growth and look at how it affects cancer cells in …

This study tests a new drug, zanzalintinib, combined with standard chemotherapy (paclitaxel) in people with recurrent high-grade uterine cancer. The goal is to find the safest and most effective dose and see if the combination can shrink tumors. About 36 participants will be enro…

This study tests whether using MRI to guide brachytherapy (internal radiation) can better target tumors and reduce radiation exposure to nearby organs like the bladder and rectum. About 54 adults with cervical, uterine, vaginal, vulvar, or bladder cancer will receive treatment in…

This study is creating a non-invasive diagnostic test to help rule out gynecological cancer in women aged 45 and older who have abnormal uterine or postmenopausal bleeding. Researchers will enroll 4,500 women to see how well the test detects cancer (sensitivity) and correctly ide…

This study looks at whether the things people buy at stores—like painkillers or indigestion remedies—could be early warning signs of cancer. Many cancers cause vague symptoms that people treat with over-the-counter products before seeing a doctor. Researchers will compare the sho…

This early-phase study tests whether fecal microbiota transplantation (FMT) can safely reduce severe diarrhea or colon inflammation caused by immune-checkpoint inhibitors in people with genitourinary and other cancers. About 40 participants will receive FMT and be monitored for s…

This study looks at whether fasting every other day can reduce the harsh side effects of chemotherapy and improve quality of life for women with ovarian, endometrial, or uterine cancer. About 30 women who have had surgery and are about to start chemotherapy will either follow an …

This study tests a precise type of proton radiation given after surgery for cervical, uterine, or endometrial cancer. The goal is to see if it causes fewer bowel side effects than standard radiation. About 25 adults who need pelvic radiation after surgery will take part.

This study aims to see if a new method of collecting fluid from the uterus (uterine lavage) can provide useful information about gynecologic diseases, including cancer. Researchers will analyze the cells and molecules in these samples from 50 women having gynecologic surgery. The…

This study collects blood and leftover tissue samples from 9,600 adults with different types of cancer, such as breast, lung, and pancreatic cancer. Researchers will use these samples to improve tests that look for tiny bits of cancer DNA in the blood, which may help detect if ca…

This study aims to collect blood samples (liquid biopsies) from 2,500 people with cancer or at high risk for cancer, along with their medical information. The samples will be stored and used by researchers to develop better ways to detect, monitor, and understand cancer over time…

This study tests whether daily CT scans can help doctors see and protect the ovaries during pelvic radiation in women under 50 with various cancers. The goal is to keep radiation doses to the ovaries low enough to avoid early menopause and infertility. Ten participants will recei…

This study is testing whether combining MRI and ultrasound images can help doctors guide needles more accurately during brachytherapy (internal radiation) for uterine cancer. Researchers will enroll 17 adults with uterine or cervical cancer who are scheduled for brachytherapy. Th…