Immune-Guiding antibody aims to clean up remaining cancer cells after transplant

NCT ID NCT05412290

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This early-phase study tests whether adding mosunetuzumab after a stem cell transplant is safe for people with aggressive B cell lymphoma that has come back or not responded to prior treatments. Mosunetuzumab is an engineered antibody that helps the body's T cells recognize and kill cancerous B cells. Nine participants will receive the drug after their transplant to see if it can prevent the cancer from returning without causing serious side effects.

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Conditions

The condition(s) this trial relates to.

aggressive B-cell non-Hodgkin lymphoma B-cell neoplasm diffuse large B-cell lymphoma follicular lymphoma high grade B-cell lymphoma primary mediastinal large B-cell lymphoma Richter transformation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States