MS mystery: why does inflammation smolder even after treatment?

NCT ID NCT06591429

Recruiting now Knowledge-focused Sponsor: Washington University School of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This observational study at Washington University will use special PET scans to look at ongoing inflammation in the brains of 25 people with relapsing-remitting multiple sclerosis. Researchers want to understand why inflammation persists even after standard treatment. Participants will have scans before and after starting anti-CD20 therapy, and researchers will compare imaging results with spinal fluid samples to see how different types of inflammation relate.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Radiotracers ([11C]-CS1P1, [11C]-DPA-713, [18F]-FDG) and anti-CD20 MS treatment
What this could lead to: If successful, this could reveal why inflammation continues in MS despite treatment, pointing toward new therapies that target smoldering inflammation.
What could go wrong: This is a small, early observational study with only 25 participants, so findings may not apply broadly. It uses imaging and biomarkers, not direct treatment outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Inflammation multiple sclerosis relapsing-remitting multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MULTIPLE SCLEROSIS

Contacts and locations

Locations

Barnes Jewish Center for Clinical Imaging Research
RECRUITING

St Louis, Missouri, 63110, United States

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