Breathing carbon dioxide to uncover hidden stroke risks in kids
NCT ID NCT04157179
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study aims to learn how blood flow and oxygen use in the brain change as children grow, especially in those with sickle cell disease who are at risk for stroke. Researchers will use MRI scans and have participants breathe in small amounts of carbon dioxide to see how well their brain blood vessels expand. The study includes healthy children and adults as well as those with sickle cell disease, and may also involve blood tests and thinking assessments.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Carbon dioxide
What this could lead to
If successful, this could help doctors better understand how blood flow and oxygen supply affect brain development and stroke risk in children with sickle cell disease.
What could go wrong
This is an observational study, not a treatment trial. It will not directly improve health, and results may not lead to new therapies for years.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Washington University of St. Louis
RECRUITINGSt Louis, Missouri, 63110, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••