Gentler stem cell transplant offers hope for blood disorders

NCT ID NCT00920972

Recruiting now Disease control Sponsor: Washington University School of Medicine Source: ClinicalTrials.gov ↗

First seen Feb 28, 2026 · Last updated May 12, 2026 · Updated 15 times

Summary

This study is testing a milder stem cell transplant for people with non-cancerous diseases like metabolic disorders, sickle cell disease, and thalassemia. The goal is to safely get donor stem cells to grow in the patient's body while reducing harsh side effects. Up to 220 participants will receive a reduced-intensity treatment before transplant, and researchers will monitor engraftment and toxicities for 100 days.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

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Locations

All Children's Hospital
COMPLETED

St. Petersburg, Florida, 33701, United States
BC Children's Hospital
COMPLETED

Vancouver, British Columbia, V6H 3N1, Canada
Carolinas Medical Center
COMPLETED

Charlotte, North Carolina, 28232, United States
Children's Hospital of New Orleans
COMPLETED

New Orleans, Louisiana, 70118, United States
Children's Hospital of Orange County
RECRUITING

Orange, California, 92868, United States

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Children's Memorial Hospital
COMPLETED

Chicago, Illinois, 60614, United States
Children's Mercy
COMPLETED

Kansas City, Missouri, 64108, United States
Columbia University Medical Center
RECRUITING

New York, New York, 10032, United States

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Cook Children's Hospital
COMPLETED

Forth Worth, Texas, 76104, United States
Duke Children's Hospital
COMPLETED

Durham, North Carolina, 27705, United States
George Washington University School of Medicine
RECRUITING

Washington D.C., District of Columbia, 20010, United States

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Hackensack University Medical Center
COMPLETED

Hackensack, New Jersey, 07601, United States
Indiana University School of Medicine
RECRUITING

Indianapolis, Indiana, 46202, United States

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Miami Children's Hospital
COMPLETED

Miami, Florida, 33155, United States
Nemours Children's Health
COMPLETED

Jacksonville, Florida, 32207, United States
Phoenix Children's Hospital
RECRUITING

Phoenix, Arizona, 85016, United States

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St. Louis University
RECRUITING

St Louis, Missouri, 63104, United States

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Texas Transplant Institute
COMPLETED

San Antonio, Texas, 78229, United States
The University of Oklahoma
COMPLETED

Oklahoma City, Oklahoma, 73104, United States
University of Calgary
COMPLETED

Calgary, Canada
University of California
RECRUITING

San Diego, California, 92123, United States

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University of Manitoba
COMPLETED

Winnipeg, Manitoba, MB R3E 0T4, Canada
University of Miami
RECRUITING

Miami, Florida, 33136, United States

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University of North Carolina
RECRUITING

Chapel Hill, North Carolina, 27514, United States

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University of Pittsburg
COMPLETED

Pittsburgh, Pennsylvania, 15224, United States
University of Utah
RECRUITING

Salt Lake City, Utah, 84132, United States

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Washington University School of Medicine (in St. Louis)
RECRUITING

St Louis, Missouri, 63110, United States

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Yale School of Medicine
RECRUITING

New Haven, Connecticut, 06510, United States

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Conditions

Explore the condition pages connected to this study.

HEMATOLOGIC, IMMUNE, OR BONE MARROW DISORDERS HEMOGLOBINOPATHIES HEMOGLOBINOPATHIES METABOLIC DISORDERS NON-MALIGNANT DISORDERS