Milder stem cell transplant shows promise for kids with immune disorders

NCT ID NCT01821781

Ongoing Disease control Sponsor: Washington University School of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a stem cell transplant using a milder chemotherapy-like regimen to treat children and young adults (up to age 28) with various immune system disorders. The goal is to help the donor stem cells settle in the body with fewer side effects. The study involves 20 participants and focuses on whether the transplant works and how safe it is.

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Conditions

The condition(s) this trial relates to.

autoimmune lymphoproliferative syndrome Bruton-type agammaglobulinemia Chediak-Higashi syndrome chronic granulomatous disease common variable immunodeficiency DiGeorge syndrome hemophagocytic syndrome hyper-IgM syndrome immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome immune system disorder inborn error of immunity Lymphohistiocytosis, Hemophagocytic lymphoproliferative syndrome severe combined immunodeficiency Wiskott-Aldrich syndrome X-linked lymphoproliferative syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME CHEDIAK-HIGASHI SYNDROME CHRONIC GRANULOMATOUS DISEASE COMMON VARIABLE IMMUNE DEFICIENCY DIGEORGE SYNDROME HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS HYPER-IGM IMMUNE DEFICIENCY DISORDERS IMMUNE DYSREGULATORY DISORDERS IPEX SEVERE COMBINED IMMUNODEFICIENCY WISKOTT-ALDRICH SYNDROME X-LINKED AGAMMAGLOBULINEMIA X-LINKED LYMPHOPROLIFERATIVE SYNDROME

Contacts and locations

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Locations

Washington University

St Louis, Missouri, 63110, United States