Suicide Gene-Equipped t cells aim to make stem cell transplants safer

This trial tests whether specially modified T cells from a partially matched donor can help patients recover their immune system faster after a stem cell transplant. The T cells are engineered with a 'suicide gene' that allows doctors to destroy them if they cause graft-versus-host disease (GvHD), a serious complication. The study enrolls people with blood cancers or immune disorders who lack a perfectly matched donor. The goal is to find a safe dose of these cells and see if they improve immune recovery without causing severe GvHD.