New drug cocktail aims to keep myeloma in check after transplant

NCT ID NCT02253316

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tests a three-drug combination (ixazomib, lenalidomide, and dexamethasone) given after a stem cell transplant to people with multiple myeloma. The goal is to see if this treatment can keep the cancer away longer. After four rounds, participants are randomly assigned to take either ixazomib or lenalidomide as long-term maintenance therapy. The study involves 236 adults aged 18 to 70.

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Conditions

The condition(s) this trial relates to.

plasma cell myeloma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • City of Hope

    Duarte, California, 91010, United States

  • Colorado Blood Cancer Institute

    Denver, Colorado, 80218, United States

  • Emory University - Winship Cancer Institute

    Atlanta, Georgia, 30322, United States

  • Icahn School of Medicine at Mount Sinai

    New York, New York, 10029, United States

  • Karmanos Cancer Institute

    Detroit, Michigan, 48201, United States

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, 43210, United States

  • Tennessee Oncology, PLLC

    Nashville, Tennessee, 37203, United States

  • University of California, San Francisco

    San Francisco, California, 94143, United States

  • Washington University School of Medicine

    St Louis, Missouri, 62864, United States