Hope for families: drug trial targets inherited Alzheimer's

NCT ID NCT01760005

First seen Nov 12, 2025 · Last updated May 12, 2026 · Updated 18 times

Summary

This study tests whether experimental drugs can slow down memory and thinking problems in people who have a genetic mutation that causes Alzheimer's disease. About 490 adults aged 18-80 with a family history of early-onset Alzheimer's will receive either the study drug or a placebo. The goal is to see if the drug can preserve cognitive function and improve brain health markers.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Advocate Lutheran General Hospital

    Park Ridge, Illinois, 60068, United States

  • Alzheimer's Research Australia

    Melbourne, Victoria, 3010, Australia

  • Azienda Ospedaliera Universitaria Careggi

    Florence, 50134, Italy

  • Brain Research Center

    Amsterdam, 1081 GM, Netherlands

  • Butler Hospital

    Providence, Rhode Island, 02096, United States

  • CHU de Quebec - Hôpital de l' Enfant Jésus

    Québec, G1J 1Z4, Canada

  • CHU de Rouen - Hôpital Charles Nicolle

    Rouen, Seine Maritime, 76031, France

  • CHU de Toulouse - Hôpital Purpan

    Toulouse, Haute Garonne, 31059, France

  • Emory University

    Atlanta, Georgia, 30329, United States

  • Groupe Hospitalier Pitie-Salpetriere

    Paris, Paris, 69677, France

  • Grupo de Neurociencias Sede de la Universidad de Antioquia

    Medellín, Colombia

  • Hopital Neurologique Pierre Wertheimer

    Bron, Rhone, 69677, France

  • Hopital Roger Salengro - CHU Lille

    Lille, Nord, 59037, France

  • Hospital Clínic I Provincial de Barcelona

    Barcelona, 8036, Spain

  • Hospital das Clínicas da Faculdade de Medicina da USP

    São Paulo, 05403-000, Brazil

  • IRCCS Centro San Giovanni di Dio Fatebenefratelli

    Brescia, 25125, Italy

  • Indiana University School of Medicine

    Indianapolis, Indiana, 46202, United States

  • Instituto de Investigaciones Neurologicas Raul Carrea, FLENI

    Ciudad Autonoma de Buenos Aire, C1428AQK, Argentina

  • Kerwin Medical Center

    Dallas, Texas, 75231, United States

  • LMU-Campus Grosshadern

    Munich, Bavaria, 81377, Germany

  • McGill Center for Studies in Aging

    Verdun, Quebec, H4H 1R3, Canada

  • Neuroscience Research Australia

    Randwick, New South Wales, 2031, Australia

  • Niigata University Medical & Dental Hospital

    Niigata, Niigata, 951-8520, Japan

  • St Vincent's University Hospital

    Dublin, DUBLIN 4, Ireland

  • Sunnybrook Health Sciences Centre

    Toronto, Ontario, M4N 3M5, Canada

  • The McCuster Foundation of Alzheimer's Disease Research

    Nedlands, Western Australia, 6009, Australia

  • The National Hospital for Neurology and Neurosurgery

    London, Greater London, WC1B 3BG, United Kingdom

  • UBC Hospital

    Vancouver, British Columbia, V6T 2B5, Canada

  • USC Keck School of Medicine

    Los Angeles, California, 90033, United States

  • Universitaetsklinikum Tubingen

    Tübingen, Baden-Wurttemberg, 72076, Germany

  • University of Alabama in Birmingham

    Birmingham, Alabama, 35294, United States

  • University of California San Diego Medical Center

    La Jolla, California, 92037, United States

  • University of Pittsburgh

    Pittsburgh, Pennsylvania, 15213, United States

  • University of Puerto Rico, School of Medicine

    San Juan, 00936, Puerto Rico

  • University of Tokyo Hospital

    Bunkyō City, Tokyo-To, 113-8655, Japan

  • University of Washington

    Seattle, Washington, 98195, United States

  • Washington University in St. Louis

    St Louis, Missouri, 63110, United States

  • Yale University School of Medicine

    New Haven, Connecticut, 06510, United States

Conditions

Explore the condition pages connected to this study.