New drug cocktail shows promise against rare cancer

NCT ID NCT04551430

First seen Nov 01, 2025 · Last updated May 16, 2026 · Updated 23 times

Summary

This study tests whether adding two immunotherapy drugs (nivolumab and ipilimumab) to the targeted therapy cabozantinib can shrink tumors better than cabozantinib alone in people with advanced soft tissue sarcoma. About 105 participants whose cancer has spread or cannot be removed and who have tried at least one prior therapy will be enrolled. The main goal is to see how many patients have their tumors shrink or disappear.

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Contacts and locations

Locations

  • Abramson Cancer Center at Pennsylvania Hospital

    Philadelphia, Pennsylvania, 19106, United States

  • Stanford University Medical Center

    Stanford, California, 94305, United States

  • University of Colorado

    Aurora, Colorado, 80045, United States

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.