Scientists probe how long monkeypox vaccine immunity lasts
NCT ID NCT06366672
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at how long the JYNNEOS vaccine protects people from smallpox and monkeypox. Researchers will measure immune responses in the blood, lungs, skin, and bone marrow of 20 healthy adults who receive the vaccine. The goal is to understand the durability of protection, which could guide future booster shot recommendations.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
JYNNEOS (smallpox and monkeypox vaccine)
What this could lead to
If successful, this could help determine how often booster shots are needed for long-lasting protection against smallpox and monkeypox.
What could go wrong
This is a very small early-phase study with only 20 healthy participants, so results may not apply to the general population or those with weakened immune systems.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Washington University in Saint Louis School of Medicine Emergency Care and Research Core
St Louis, Missouri, 63110, United States