Scientists probe how long monkeypox vaccine immunity lasts
NCT ID NCT06366672
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at how long the JYNNEOS vaccine protects people from smallpox and monkeypox. Researchers will measure immune responses in the blood, lungs, skin, and bone marrow of 20 healthy adults who receive the vaccine. The goal is to understand the durability of protection, which could guide future booster shot recommendations.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- JYNNEOS (smallpox and monkeypox vaccine)
- What this could lead to
- If successful, this could help determine how often booster shots are needed for long-lasting protection against smallpox and monkeypox.
- What could go wrong
- This is a very small early-phase study with only 20 healthy participants, so results may not apply to the general population or those with weakened immune systems.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Washington University in Saint Louis School of Medicine Emergency Care and Research Core
St Louis, Missouri, 63110, United States
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