OBSTRUCTIVE SLEEP APNEA

This study tests whether a device can detect when a patient's breathing slows after surgery and then play a recorded voice telling them to breathe. The device uses standard monitors already used in hospitals. The study includes patients who have or may have sleep apnea and are st…

This study tests a device that stimulates a nerve in the neck to keep the airway open during sleep. It is for adults with moderate to severe obstructive sleep apnea who cannot use a CPAP machine. The goal is to see if the device is safe and improves breathing and sleep quality.

This Phase 3 trial tests retatrutide, a once-weekly injection, in 1000 adults with type 2 diabetes who are overweight or obese. The study also looks at a subset of participants with obstructive sleep apnea. Over 89 weeks, researchers will measure weight loss, changes in sleep apn…

This study follows 110 adults with moderate to severe obstructive sleep apnea who have the Genio® device implanted. The device stimulates a nerve to keep the airway open during sleep. Researchers will track safety and effectiveness over 5 years, including changes in breathing pau…

This study looks at whether using a CPAP machine to treat obstructive sleep apnea can help improve insulin resistance and hormone levels in women with Polycystic Ovary Syndrome (PCOS). Researchers will measure changes in fat production, testosterone, and insulin in 20 women aged …

This study tests whether the sleep medication trazodone can slow memory loss in people with mild cognitive impairment and obstructive sleep apnea. Researchers will measure changes in blood markers and thinking skills over one year. 134 participants are enrolled in this double-bli…

This study follows children with hypotonia (low muscle tone) who have obstructive sleep apnea. They use a flexible silicone nasal tube called ssNPA at night to keep the airway open. Researchers will check how well it works and if children can tolerate it over a year.

This study tests whether a time-efficient breathing exercise program can help lower blood pressure in adults aged 50 and older who have moderate to severe sleep apnea but cannot or will not use a CPAP machine. Researchers will measure blood pressure changes over 36 weeks in 122 p…

This study tests a device that stimulates a nerve in the neck to treat sleep apnea in 57 teens and young adults (ages 10-21) with Down syndrome. The goal is to see if better sleep leads to improvements in thinking, attention, and language skills over 12 months. Participants must …

This study checks how well a new home sleep test system called SleepView+ can diagnose moderate to severe obstructive sleep apnea in people ages 12 and older. About 200 participants will first use the device during an overnight lab sleep study to compare results, then try it at h…

This study explores whether parents can use their smartphones to record short videos of their child sleeping to screen for obstructive sleep apnea (OSA). Children with Down syndrome are at higher risk for OSA, but standard sleep studies can be hard to access. Parents will rate th…

This study checks if a special mouthpiece that measures oxygen levels during sleep is as accurate as the standard sleep lab test. Thirty adults with obstructive sleep apnea will wear the device overnight in a sleep lab. If it works well, it might offer a simpler way to track oxyg…

This study tests whether drinking a ketone supplement (Ketone-IQ) before bed can improve sleep quality and reduce sleep apnea severity in 30 adults who already use a CPAP machine. Participants will try two different doses and compare effects to a placebo. The goal is to find a si…

This study tests whether a numbing injection near the glossopharyngeal nerve, combined with topical anesthesia, can help people recover faster after surgery for obstructive sleep apnea. The trial involves 80 adults with moderate to severe sleep apnea who are scheduled for palatop…

This study tests a combination of two medicines (atomoxetine and oxybutynin) given at bedtime for 6 months to children aged 6-17 with Down syndrome and obstructive sleep apnea. The goal is to see if the treatment improves sleep quality and thinking skills. About 36 children will …

This study tests whether high-flow oxygen therapy can prevent low oxygen levels (hypoxemia) in patients at higher risk during sedated digestive endoscopy. The trial includes 326 adults with obesity, sleep apnea, or stable lung or heart conditions. Researchers will compare high-fl…

This study aimed to see if using a special nasal mask that provides positive airway pressure (PAP) during colonoscopy sedation could reduce the frequency, length, and severity of low oxygen levels compared to standard oxygen through a nasal cannula. The study planned to enroll hi…

This study tests whether showing people with sleep apnea how their CPAP machine use compares to other patients helps them use it more consistently. About 186 adults who have been on CPAP for at least three months will be split into two groups: one gets routine feedback on their o…

This study compares two common surgical tools (monopolar and bipolar electrocautery) used during tonsil removal to see which one causes less pain and bleeding after surgery. It involves 74 people aged 5 to 40 who need their tonsils out due to chronic tonsillitis or other issues. …

This study examines how common obstructive sleep apnea (OSA) is in adult survivors of Hodgkin lymphoma who received chest radiation. Researchers will compare 220 survivors to matched controls using sleep tests, brain scans, and heart assessments. The goal is to understand links b…

This study is testing a new type of clinic that screens people with prediabetes and type 2 diabetes for several hidden health problems at the same time, including fatty liver disease, sleep apnea, and heart failure. The goal is to see how common these undiagnosed conditions are a…

This study looks at how sleep apnea might cause prediabetes to turn into diabetes. Researchers will use CPAP machines and niacin infusions in 300 overweight, prediabetic adults with sleep apnea to measure changes in blood chemicals. The goal is to understand the biological steps …

This small study tests whether the supplement N-acetylcysteine (NAC) can reduce oxidative stress and inflammation in people with obstructive sleep apnea who are already using standard PAP therapy. Researchers want to see if the effects differ between men and women. The study invo…

This study compares two ways to predict heart and metabolic problems in people with mild-to-moderate obstructive sleep apnea: one based on inflammation in the body, and the other based on how severe the sleep apnea is. Researchers will measure things like waist size, blood pressu…

This study looks at whether treating obstructive sleep apnea (OSA) with a breathing device (CPAP) lowers blood pressure more in people who are very sleepy compared to those who are not. Researchers will analyze data from about 10,000 adults with OSA from previous studies. The goa…

This study aims to understand the genetic factors behind obstructive sleep apnea (OSA) and its related health issues. Researchers will enroll 5,000 adults who have been diagnosed with or are suspected of having sleep apnea. Participants will provide genetic samples and answer sle…

This study looks at whether sleep-disordered breathing, like obstructive sleep apnea, is linked to worsening spine curves in children with idiopathic scoliosis. Researchers will follow 405 children aged 6 to 15 with mild to moderate scoliosis. They will measure spine curves and s…

This study looks at whether remote video visits (tele-visits) work as well as in-person home visits for people using a CPAP machine to treat sleep apnea. About 320 adults who have been using CPAP for at least a year will take part. The main goal is to see if tele-visits help peop…

This study looks at whether leaving a breathing tube in for 24-48 hours after gastric cancer surgery can lower complications in patients who also have severe obstructive sleep apnea. Researchers will compare two groups of 240 patients: one with standard tube removal and one with …

This study looks at how stimulating two specific tongue muscles (palatoglossus and genioglossus) affects airway size during a sleep endoscopy procedure. Researchers will measure changes in the airway with and without stimulation in 60 adults with obstructive sleep apnea who canno…

This study follows 10,000 people with both obstructive sleep apnea and high blood pressure over many years. Researchers will track how well patients use CPAP machines and blood pressure medications, and whether this reduces the chance of heart attacks, strokes, heart failure, or …

This study looks at children aged 10-15 who need braces for prominent upper front teeth. Some will have upper premolars removed as part of treatment, others will not. Researchers will use sleep studies before and after treatment to see if the extractions increase the risk of obst…

This early study at Mayo Clinic tests whether using a device that massages the legs at night can help the brain clear waste products better in people with obstructive sleep apnea. The study involves 12 adults aged 50 and older who already use CPAP therapy. Researchers will measur…

This study looks at whether long-term use of a breathing device called adaptive servo-ventilation (ASV) can improve how the heart uses energy and how nerves work in people with heart failure and sleep apnea. Researchers will use PET scans to measure heart metabolism and nerve fun…

This study was designed to find out if treating obstructive sleep apnea with a CPAP machine could help improve insulin resistance and heart function in people with heart failure. It planned to enroll adults aged 18 to 75 with moderate to severe sleep apnea and reduced heart pumpi…

This study was designed to explore how the glossopharyngeal nerve varies in shape and size, and whether electrically stimulating it could open the airway during surgery. It planned to enroll adults with head and neck cancer or sleep apnea, but was withdrawn before any participant…

This study aims to create a computer model that can predict how airway surgery will affect obstructive sleep apnea (OSA) in children with Down syndrome. Researchers will measure airway resistance during a sleep MRI to gather data for the model. The goal is to help doctors choose …

This study checks whether sleep questionnaires can reliably detect obstructive sleep apnea (OSA) in children with Down syndrome, who are at higher risk for the condition. Researchers will compare questionnaire results with overnight sleep studies (the gold standard) in about 81 c…

This study was designed to understand how obstructive sleep apnea (OSA) speeds up the natural drop in testosterone as men age. Researchers planned to use CPAP machines—one real, one placebo—to test hormone changes in men aged 30 to 70 with moderate to severe OSA. However, the stu…