OBSTRUCTIVE SLEEP APNEA

This study tests a device that stimulates a nerve in the tongue to treat sleep apnea in 57 teens and young adults (ages 10-21) with Down syndrome. The goal is to see if treating sleep apnea this way improves thinking, attention, memory, and language skills over 12 months. Partici…

This study tests a combination of two drugs (atomoxetine and oxybutynin) given at bedtime to children with Down syndrome who have obstructive sleep apnea. The goal is to see if the treatment improves breathing during sleep and thinking skills. Thirty-six children aged 6 to 17 wil…

This study tests whether trazodone, a medication used for sleep, can slow down memory loss and brain changes in people with mild cognitive impairment and obstructive sleep apnea. About 134 participants will take either trazodone or a placebo for one year. Researchers will measure…

This study looks at whether showing sleep apnea patients how their CPAP machine use compares to other patients helps them use it more regularly. About 186 adults who have been on CPAP for at least three months will be split into two groups: one gets only their own usage data, the…

This study follows 110 adults with moderate to severe obstructive sleep apnea who have the Genio® device implanted. The goal is to see if the device is safe and works well over 5 years by tracking serious side effects, breathing improvements, and quality of life. Participants had…

This study tests a device implanted under the chin that stimulates a nerve to keep the airway open during sleep. It is for adults with moderate to severe sleep apnea who cannot use a CPAP machine. The main goal is to see if the device safely reduces breathing pauses and low oxyge…

This study tests whether a time-efficient breathing exercise (inspiratory muscle strength training) can lower blood pressure and improve heart health in adults aged 50 and older with moderate to severe obstructive sleep apnea. Participants who cannot or will not use a CPAP machin…

This study tests a once-weekly medicine called retatrutide in about 1000 adults with type 2 diabetes who are also overweight or have obesity. The goal is to see if it helps with weight loss and, for a smaller group, improves sleep apnea. Participants will receive either the drug …

This study looks at how well a special nasal tube works over time for children with weak muscle tone (hypotonia) who have obstructive sleep apnea. About 40 children who already used the device in earlier studies will continue using it. Researchers will check if it keeps the airwa…

This study looks at how treating obstructive sleep apnea with CPAP affects insulin resistance and hormone levels in women with Polycystic Ovary Syndrome (PCOS). Researchers will measure changes in fat production, testosterone, and insulin secretion in 20 participants. The goal is…

This study checks if a new home sleep test called SleepView+ can correctly identify moderate to severe obstructive sleep apnea in people aged 12 and older. About 200 participants will first use the device in a sleep lab alongside standard tests, then try it at home on their own. …

This study explores whether short video clips recorded by parents on their smartphones can help identify children with Down syndrome who are at high risk for obstructive sleep apnea (OSA). About 141 children will participate. Parents will record their child sleeping and then gues…

This study checks if a new device called RPMO2 can accurately measure drops in oxygen levels during sleep in 30 adults with obstructive sleep apnea. Participants will wear the device during one night in a sleep lab, and its readings will be compared to the standard sleep test (po…

This study tests whether taking a commercially available ketone drink (Ketone-IQ) before bed can improve sleep quality and reduce sleep apnea severity in 30 adults who already use CPAP. Participants will try two different doses and compare effects to a placebo. The goal is to fin…

This study checks if simple sleep questionnaires can accurately detect obstructive sleep apnea in children with Down syndrome, who are at higher risk. About 81 children aged 2-17 will answer sleep questions and have their results compared to a standard overnight sleep test. The g…

This study looks at how stimulating two tongue muscles (palatoglossus and genioglossus) during a sleep endoscopy procedure affects airway size in people with obstructive sleep apnea. Researchers will measure changes in airway diameter with and without stimulation. The goal is to …

This early study at Mayo Clinic tests whether using an automated leg massage device (Neuroglide) each night for one month can improve the brain's waste-clearing system in people aged 50+ with obstructive sleep apnea. Researchers will measure changes in blood markers linked to bra…

This study looks at whether waiting longer to remove the breathing tube after stomach cancer surgery can reduce complications in patients who also have severe sleep apnea. Researchers will track 240 adults aged 18-85 who are having their stomach cancer removed. The goal is to fin…

This study looks at how myofunctional therapy (exercises for the tongue and throat muscles) might help people with obstructive sleep apnea. Thirty adults will use special devices for 3 months while researchers measure muscle pressure during swallowing and breathing. The goal is t…

This study looks at 196 adults with mild-to-moderate obstructive sleep apnea to see whether inflammation or the severity of breathing pauses during sleep better predicts heart and metabolic problems. Participants will have their sleep, blood markers, and heart rate variability me…

This study looks at how a breathing device called adaptive servo-ventilation (ASV) affects heart energy use and nerve function in people with heart failure and sleep apnea. Researchers will measure heart metabolism and efficiency using PET scans and heart rate monitoring. The goa…

This study checks if removing upper premolars to fix a large overbite in children aged 10-15 increases the risk of obstructive sleep apnea. Researchers will compare kids who had extractions with those who didn't, using sleep tests before and after treatment. The goal is to see if…

This study looks at whether the supplement N-acetylcysteine (NAC) affects markers of oxidative stress and inflammation differently in men and women with obstructive sleep apnea. Fourteen participants who already use standard CPAP therapy will take NAC or a placebo for 4 weeks. Th…

This study looked at whether sleep-disordered breathing (like sleep apnea) is linked to faster spine curve worsening in children with idiopathic scoliosis. Researchers followed 405 children aged 6-15 with mild to moderate curves. They measured spine angles and sleep quality to se…

This study was designed to find out how obstructive sleep apnea (OSA) speeds up the natural drop in testosterone as men age. It planned to enroll men aged 30 to 70 with moderate to severe OSA and measure hormone responses. However, the study was withdrawn before any participants …

This study aims to find genetic variations that contribute to obstructive sleep apnea and its related health issues. Researchers will collect data from 5,000 adults who have or are suspected of having sleep apnea. Participants will fill out sleep questionnaires and provide geneti…

This study looks at whether a video call (tele-visit) works as well as a home visit from a healthcare provider to help people with obstructive sleep apnea stick to their CPAP therapy. About 320 adults who have been using CPAP for at least a year will take part. The goal is to see…

This study examines how common obstructive sleep apnea (OSA) is in adult survivors of Hodgkin lymphoma who received chest radiation. Researchers will compare 220 survivors to matched healthy controls using sleep tests, brain scans, and neck muscle measurements. The goal is to und…

This study looks at 10,000 people who have both sleep apnea and high blood pressure. Researchers will track them over many years to see how well they use their sleep apnea machine (PAP) and blood pressure medicines, and whether that affects their risk of heart attacks, strokes, h…

This study looks at whether treating obstructive sleep apnea (OSA) with a CPAP machine affects blood pressure differently in people who are very sleepy versus those who are not. Researchers will analyze data from about 10,000 adults with OSA who were part of previous studies. The…

This study was designed to find out if treating obstructive sleep apnea with a CPAP machine could improve insulin resistance and heart function in people with heart failure. It planned to enroll adults under 75 with moderate to severe sleep apnea and reduced heart pumping ability…

This study aimed to map the glossopharyngeal nerve and test if electrical stimulation could open the airway in people with head and neck cancer and sleep apnea. It was withdrawn before enrolling anyone, so no results are available. The goal was to better understand nerve anatomy …

This study aims to create a computer model that predicts how airway surgery will affect obstructive sleep apnea (OSA) in children with Down syndrome. Researchers will measure airway resistance during sleep MRI scans in about 73 participants. The goal is to better plan surgeries a…