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Can a sleep drug slow memory decline?

NCT ID NCT05209035

Ongoing Disease control Sponsor: Chinese University of Hong Kong Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether the sleep medication trazodone can slow memory loss in people with mild cognitive impairment and obstructive sleep apnea. Researchers will measure changes in blood markers and thinking skills over one year. 134 participants are enrolled in this double-blind, placebo-controlled trial.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Trazodone
What this could lead to
If it works, this could point toward a treatment that slows memory loss in people with mild cognitive impairment and sleep apnea.
What could go wrong
This is a small, early-phase trial testing a biomarker, not a proven treatment. The drug may not slow cognitive decline, and side effects like drowsiness are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction obstructive sleep apnea syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MILD COGNITIVE IMPAIRMENT OBSTRUCTIVE SLEEP APNEA

Contacts and locations

Locations

  • The Chinese University of Hong Kong

    Hong Kong, Hong Kong

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